Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Joseph A. Oliva"'
Publikováno v:
Crystal Growth & Design. 21:6684-6696
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76360022c8796a013300beed5604da48
https://doi.org/10.1021/acs.cgd.1c00301
https://doi.org/10.1021/acs.cgd.1c00301
Publikováno v:
Chemical Engineering Research and Design. 161:322-331
Compartment models (CMs) are widely used to capture typical hydrodynamic features of systems, generally having low computational cost. The main building blocks of the CMs are the continuous stirred tank reactor and plug flow reactor models. In this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::598e6686dd4ce2c21c3f7339928acc41
https://doi.org/10.1016/j.cherd.2020.07.011
https://doi.org/10.1016/j.cherd.2020.07.011
Publikováno v:
Crystal Growth & Design. 20:934-947
Continuous protein crystallization is a cost-effective alternative to traditional chromatographic purification techniques. However, proteins characteristically have slow growth rates, requiring long crystallization times to generate particles large e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd7365d948170c0d13b417b206305a29
https://doi.org/10.1021/acs.cgd.9b01313
https://doi.org/10.1021/acs.cgd.9b01313
Publikováno v:
Chemical Engineering Journal. 351:498-505
Oscillatory flow strategies through baffled tubular reactors provide an efficient approach in improving process kinetics through enhanced micromixing and heat transfer. Known to have high surface area to volume ratios, oscillatory flow baffled reacto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de4b6a4775e3113c62d974db8e2acc16
https://doi.org/10.1016/j.cej.2018.06.029
https://doi.org/10.1016/j.cej.2018.06.029
Publikováno v:
Crystal Growth & Design. 17:4776-4784
Drug substance purification by crystallization is a key interface in going from drug substance synthesis to final formulation and can often be a bottleneck in process efficiency. There has been increased importance in the development of continuous cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ff77af69794e19536c5f006c2e40652
https://doi.org/10.1021/acs.cgd.7b00731
https://doi.org/10.1021/acs.cgd.7b00731
Dissertation/ Thesis
Autor:
Joseph A Oliva (6588797)
Guided by the continuous manufacturing paradigm shift in the pharmaceutical industry, the proposed thesis focuses on the implementation of an integrated continuous crystallization platform, the oscillatory baffled crystallizer (OBC), with real time p
