Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Joseph A. Liberman"'
Autor:
Ruth A. Ettinger, Joseph A. Liberman, Devi Gunasekera, Komal Puranik, Eddie A. James, Arthur R. Thompson, Kathleen P. Pratt
Publikováno v:
Blood Advances, Vol 2, Iss 4, Pp 309-322 (2018)
Abstract: Factor VIII (FVIII)–neutralizing antibodies (inhibitors) are a serious complication in hemophilia A (HA). The peptide FVIII2194-2213 contains an immunodominant HLA-DRA*01-DRB1*01:01 (DRB1*01:01)-restricted epitope recognized by CD4+ T-eff
Externí odkaz:
https://doaj.org/article/8cdfc0df3f83466e80e9f6064c811ebe
Autor:
Jun Feng, Arlie J. Rinaldi, Catherine D. Eichhorn, Nils G. Walter, Charles L. Brooks, Anthony M. Mustoe, Hashim M. Al-Hashimi, Joseph E. Wedekind, Joseph A. Liberman, Krishna C. Suddala
Publikováno v:
Nucleic Acids Research
Riboswitches are structural elements in the 5' untranslated regions of many bacterial messenger RNAs that regulate gene expression in response to changing metabolite concentrations by inhibition of either transcription or translation initiation. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d93ff85c09e9fcad33b69e12c0a664
https://doi.org/10.1093/nar/gkt798
https://doi.org/10.1093/nar/gkt798
Autor:
Joseph A. Liberman, Joseph E. Wedekind
Publikováno v:
Wiley Interdisciplinary Reviews: RNA. 3:369-384
Molecular investigations of riboswitches bound to small-molecule effectors have produced a wealth of information on how these molecules achieve high affinity and specificity for a target ligand. X-ray crystal structures have been determined for the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::477f1e0ebcfed85ce82cda161b74149c
https://doi.org/10.1002/wrna.114
https://doi.org/10.1002/wrna.114
Autor:
Joseph E. Wedekind, Joseph A. Liberman
Publikováno v:
Current Opinion in Structural Biology. 21:327-334
Genome sequencing has produced thousands of nonprotein coding (nc)RNA sequences including new ribozymes and riboswitches. Such RNAs are notable for their extraordinary functionality, which entails exquisite folding that culminates in biocatalytic or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fdbfb83f5f0f33daebb04603a484aa9
https://doi.org/10.1016/j.sbi.2011.03.016
https://doi.org/10.1016/j.sbi.2011.03.016
Autor:
Ruth A. Ettinger, Jan Voorberg, S. D. Van Haren, Kathleen P. Pratt, Eddie A. James, Karin Fijnvandraat, William W. Kwok, Joseph A. Liberman
Publikováno v:
Journal of thrombosis and haemostasis, 9(4), 689-699. Wiley-Blackwell
Summary. Background: Development of neutralizing anti-factor (F)VIII antibodies (‘inhibitors’) is a serious clinical problem in hemophilia A. Increased inhibitor risk has been associated with certain FVIII missense substitutions, including R593C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bcaae37478bc34e36093c2afe02bbea
https://doi.org/10.1111/j.1538-7836.2011.04202.x
https://doi.org/10.1111/j.1538-7836.2011.04202.x
Autor:
Dalen Chan, Joseph A. Liberman, Joseph E. Wedekind, Nils G. Walter, Robert C. Spitale, Asaminew H. Aytenfisu, Mohammad Salim, Krishna C. Suddala, Ivan A. Belashov, David H. Mathews
Publikováno v:
Liberman, JA; Suddala, KC; Aytenfisu, A; Chan, D; Belashov, IA; Salim, M; et al.(2015). Structural analysis of a class III preQ1riboswitch reveals an aptamer distant from a ribosome-binding site regulated by fast dynamics. Proceedings of the National Academy of Sciences of the United States of America, 112(27), E3485-E3494. doi: 10.1073/pnas.1503955112. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/16m5p6j4
PreQ1-III riboswitches are newly identified RNA elements that control bacterial genes in response to preQ1 (7-aminomethyl-7-deazaguanine), a precursor to the essential hypermodified tRNA base queuosine. Although numerous riboswitches fold as H-type o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ab3ead27c44c2cc4c082e03b7b25de
https://pubmed.ncbi.nlm.nih.gov/26106162
https://pubmed.ncbi.nlm.nih.gov/26106162
Publikováno v:
RNA (New York, N.Y.). 21(11)
Riboswitches are RNA molecules that regulate gene expression using conformational change, affected by binding of small molecule ligands. A crystal structure of a ligand-bound class II preQ1 riboswitch has been determined in a previous structural stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f74ff23f50b188b0481a4f70c25b8600
https://pubmed.ncbi.nlm.nih.gov/26370581
https://pubmed.ncbi.nlm.nih.gov/26370581
Publikováno v:
Nature chemical biology
PreQ1 riboswitches regulate genes by binding the pyrrolopyrimidine intermediate preQ1 during the biosynthesis of the essential tRNA base queuosine. We report what is to our knowledge the first preQ1-II riboswitch structure at 2.3-Å resolution, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6478e9e7e34b9c295b3eb41675867edf
https://doi.org/10.1038/nchembio.1231
https://doi.org/10.1038/nchembio.1231
Publikováno v:
Chemical Biology of Nucleic Acids ISBN: 9783642544514
Riboswitches are functional RNA elements located most frequently within the 5′-leader sequences of bacterial mRNAs. By directly binding to small molecules via an aptamer domain, a riboswitch can adapt quickly to changes in the concentration of a sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e27c8c83b37c9e96f7b524a4a529c8f5
https://doi.org/10.1007/978-3-642-54452-1_23
https://doi.org/10.1007/978-3-642-54452-1_23
Riboswitches regulate genes by binding to small-molecule effectors. Isothermal titration calorimetry (ITC) provides a label-free method to quantify the equilibrium association constant, K(A), of a riboswitch interaction with its cognate ligand. In ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ec2be88cd3a582d1d2c83a18d38ff7
https://europepmc.org/articles/PMC5749633/
https://europepmc.org/articles/PMC5749633/