Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Joseph A. Knezetic"'
Autor:
Joseph A. Knezetic, Zoran Gatalica, Rebecca Feldman, Theodoros N. Teknos, Cherie-Ann O. Nathan, Sandeep K. Reddy, Nader Javadi
Publikováno v:
Head & Neck. 38:E1625-E1638
Background Head and neck squamous cell carcinoma (HNSCC) exhibits high rates of recurrence, and with few approved targeted agents, novel treatments are needed. We analyzed a molecular profiling database for the distribution of biomarkers predictive o
Publikováno v:
Expert Opinion on Medical Diagnostics. 6:485-488
There are many ways in which a diagnosis of Lynch syndrome can be made, most prominent of which is family history, presence of cancer, high microsatellite instability, immunohistochemistry, and a mismatch repair germline mutation. There are at least
Autor:
Gloria J. Morris, Christian S. Adonizio, Julie M. Eggington, Christina Rybak, Michelle Gazzillo, Kristina Lowstuter, Henry T. Lynch, Michael J. Hall, Carrie Snyder, Joseph A. Knezetic
Publikováno v:
Seminars in Oncology. 39:125-131
Publikováno v:
Applied Immunohistochemistry & Molecular Morphology. 19:574-578
Human papillomaviruses (HPVs) have been etiologically linked to a subset of head and neck squamous cell carcinomas (HNSCCs), generally arising in young patients without a history of tobacco smoking or alcohol use. These tumors typically lack mutation
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. :503-506
The association between the restriction length polymorphisms of the Vitamin D receptor (VDR) gene and the bone mineral density (BMD) or the rate of bone loss is still under debate. In a longitudinal study of untreated postmenopausal elderly women, we
Autor:
Riccardo Fodde, Joseph A. Knezetic, Rodney J Taylor, Ali Barrows, Anja Wagner, Juul T. Wijnen, Henry T. Lynch, Jane F. Lynch
Publikováno v:
American Journal of Gastroenterology, 98(3), 664-670. Springer Nature
Objective We report a multigeneration family where colorectal cancer and cancer of multiple diverse anatomic sites, inclusive of transitional cell carcinoma of the upper uroepithelial tract, were manifested in several relatives. Methods A specific pa
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 503:37-42
Hereditary non-polyposis colorectal cancer (HNPCC), or Lynch syndrome I, is responsible for as high as 10% of all colorectal cancers (CRCs) newly diagnosed in any given year. This disorder has an autosomal dominant inheritance pattern and is almost f
Publikováno v:
Pancreas. 24:161-168
INTRODUCTION Pancreatic cancer cells are susceptible to antiproliferative effects of cytokines such as tumor necrosis factor-alpha (TNF-alpha). However, little is known about the mechanisms involved. AIM To determine the mechanisms of the antiprolife
Publikováno v:
Blood Cells, Molecules, and Diseases. 28:275-282
Virus-like 30S (VL30) elements are endogenous retro-elements of the mouse retrotransposon family. These elements are transcriptionally responsive in a temporal and tissue-specific manner due to the U3 promoter region of the elements' long terminal re
Publikováno v:
Current treatment options in oncology. 15(3)
Molecular genetic pathways that drive the phenotypic and genotypic heterogeneity of hereditary colorectal cancer also can affect response to chemotherapy and chemoprevention. These mutations also can alter patients’ response to therapy. Environment