Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Joseph A. Kirk"'
Autor:
Michael J. Ormsby, Filipa Vaz, Joseph A. Kirk, Anna Barwinska-Sendra, Jennifer C. Hallam, Paola Lanzoni-Mangutchi, John Cole, Roy R. Chaudhuri, Paula S. Salgado, Robert P. Fagan, Gillian R Douce
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6 (2023)
Clostridioides difficile is responsible for substantial morbidity and mortality in antibiotically-treated, hospitalised, elderly patients, in which toxin production correlates with diarrhoeal disease. While the function of these toxins has been studi
Externí odkaz:
https://doaj.org/article/c86b98dea6594503baae7233de32c14f
Autor:
Paola Lanzoni-Mangutchi, Oishik Banerji, Jason Wilson, Anna Barwinska-Sendra, Joseph A. Kirk, Filipa Vaz, Shauna O’Beirne, Arnaud Baslé, Kamel El Omari, Armin Wagner, Neil F. Fairweather, Gillian R. Douce, Per A. Bullough, Robert P. Fagan, Paula S. Salgado
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The S-layer is a two-dimensional protein array that covers the cell surface of many bacteria and archaea. Here, the authors use high-resolution X-ray crystallography and electron microscopy to provide detailed insights into S-layer organisation and a
Externí odkaz:
https://doaj.org/article/060e552494ad40e5a8e3a8037d7d898a
Autor:
Alexia L. M. Royer, Andrew A. Umansky, Marie-Maude Allen, Julian R. Garneau, Maicol Ospina-Bedoya, Joseph A. Kirk, Gregory Govoni, Robert P. Fagan, Olga Soutourina, Louis-Charles Fortier
Publikováno v:
Microbiology Spectrum. 11
Phage therapy represents an interesting alternative to treat Clostridioides difficile infections because, contrary to antibiotics, most phages are highly species specific, thereby sparing the beneficial gut microbes that protect from infection. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b1cc7704b20e69fae14f2e380db6da1
https://doi.org/10.1128/spectrum.03894-22
https://doi.org/10.1128/spectrum.03894-22
Autor:
Michael J. Ormsby, Filipa Vaz, Joseph A. Kirk, Anna Barwinska-Sendra, Jennifer C. Hallam, Paola Lanzoni-Mangutchi, John Cole, Roy R. Chaudhuri, Paula S. Salgado, Robert P. Fagan, Gillian R Douce
Clostridioides difficileis responsible for substantial morbidity and mortality in antibiotically-treated, hospitalised, elderly patients, in which toxin production correlates with diarrhoeal disease. While the function of these toxins has been studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b1d4dd2aa6da04add1e8f03717be880
https://doi.org/10.1101/2022.11.22.517470
https://doi.org/10.1101/2022.11.22.517470
Autor:
Alexia L.M. Royer, Andrew A. Umansky, Marie-Maude Allen, Julian R. Garneau, Maicol Ospina-Bedoya, Joseph A. Kirk, Gregory Govoni, Robert P. Fagan, Olga Soutourina, Louis-Charles Fortier
Therapeutic bacteriophages (phages) are being considered as alternatives in the fight against Clostridioides difficile infections. To be efficient, phages should have a wide host range, but the lack of knowledge about the cell receptor used by C. dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9928e28c3e85dbccfffc7785ac7f53c
https://doi.org/10.1101/2022.09.19.508581
https://doi.org/10.1101/2022.09.19.508581
Autor:
Paola, Lanzoni-Mangutchi, Oishik, Banerji, Jason, Wilson, Anna, Barwinska-Sendra, Joseph A, Kirk, Filipa, Vaz, Shauna, O'Beirne, Arnaud, Baslé, Kamel, El Omari, Armin, Wagner, Neil F, Fairweather, Gillian R, Douce, Per A, Bullough, Robert P, Fagan, Paula S, Salgado
Publikováno v:
Nature communications. 13(1)
Many bacteria and archaea possess a two-dimensional protein array, or S-layer, that covers the cell surface and plays crucial roles in cell physiology. Here, we report the crystal structure of SlpA, the main S-layer protein of the bacterial pathogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db4c5f14d356b221a51d35d006e58f9e
https://pubmed.ncbi.nlm.nih.gov/35217634
https://pubmed.ncbi.nlm.nih.gov/35217634
Autor:
Vanessa Lamm-Schmidt, Jörg Vogel, Johannes Sulzer, Falk Ponath, Lars Barquist, Laura Jenniches, Manuela Fuchs, Franziska Faber, Robert P. Fagan, Joseph A. Kirk
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
United Kingdom
United States
United Kingdom
United States
Significance Clostridioides difficile is the leading cause of healthcare-associated diarrhea worldwide following antibiotic treatment. Consequently, there is medical need for novel antibacterial agents acting against C. difficile that leave the resid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30e2ebd042da8f6e95cd812b731a116b
https://doi.org/10.1073/pnas.2103579118
https://doi.org/10.1073/pnas.2103579118
Publikováno v:
Anaerobe
Background Sporulation is a complex cell differentiation programme shared by many members of the Firmicutes, the end result of which is a highly resistant, metabolically inert spore that can survive harsh environmental insults. Clostridioides diffici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5b2971a6ace033ac6256624d6b7b17
https://pubmed.ncbi.nlm.nih.gov/33940167
https://pubmed.ncbi.nlm.nih.gov/33940167
Autor:
Gill Douce, Robert P. Fagan, P. Lanzoni-Mangutchi, Joseph A. Kirk, Armin Wagner, Per A. Bullough, A. Basle, A. Barwinska-Sendra, J. Wilson, Paula S. Salgado, Oishik Banerji, S. O'Beirne, F. Vaz, Neil F. Fairweather, K. El Omari
Publikováno v:
In Review
Many bacteria and archaea possess a cell surface layer – S-layer – made of a 2D protein array that covers the entire cell. As the outermost component of the cell envelope, S-layers play crucial roles in many aspects of cell physiology. Importantl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b188406298cabdf91ae622a488e0b8
https://doi.org/10.21203/rs.3.rs-79088/v1
https://doi.org/10.21203/rs.3.rs-79088/v1
Sporulation is a complex cell differentiation programme shared by many members of the Firmicutes, the end result of which is a highly resistant, metabolically inert spore that can survive harsh environmental insults. Clostridium difficile spores are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e33464365f4bb634f9e869cf9f5a4fd