Výsledky vyhledávání - "Joseph A. Ioppolo"

Akademický článek

[1,2-Bis(diphenylphosphino)-1,2-dicarba-closo-dodecaborane-κ2P,P′][7,8-bis(diphenylphosphino)-7,8-dicarba-nido-undecaborato-κ2P,P′]gold(I)–dichloromethane–water (2/1/1)

Autor: Louis M. Rendina, Jack K. Clegg, Joseph A. Ioppolo

Publikováno v: Acta Crystallographica Section E, Vol 65, Iss 5, Pp m603-m604 (2009)

The title compound, [Au(C26H30B10P2)(C26H30B9P2)]·0.5CH2Cl2·0.5H2O, contains two independent complex molecules in the asymmetric unit. The gold(I) centres display a distorted tetrahedral geometry. The complex is stablized through weak intramolecula

Externí odkaz: https://doaj.org/article/cb3b6fc4a0814c879ee03d9163df8394

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67 Ga-labeled deferoxamine derivatives for imaging bacterial infection: Preparation and screening of functionalized siderophore complexes

Autor: Paul J. Berti, Omid Beiraghi, John F. Valliant, Lisset Llano, Megan Blacker, Joseph A. Ioppolo, Deanna Caldwell

Publikováno v: Nuclear Medicine and Biology. 52:32-41

Introduction Deferoxamine (DFO) is a siderophore that bacteria use to scavenge iron and could serve as a targeting vector to image bacterial infection where current techniques have critical limitations. [ 67 Ga]-DFO, which is a mimetic of the corresp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50d40e8f0ad7183a0967ac620965e917
https://doi.org/10.1016/j.nucmedbio.2017.05.010

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Direct in vivo comparison of [18F]PSMA-1007 with [68Ga]Ga-PSMA-11 and [18F]AlF-PSMA-11 in mice bearing PSMA-expressing xenografts

Autor: Kirsty L. Richardson, Roger I. Price, Peter J. Leedman, Rikki A. Nezich, Joseph A. Ioppolo, Laurence Morandeau

Publikováno v: Applied Radiation and Isotopes. 161:109164

The aim of this preclinical study was to directly compare [18F]PSMA-1007 with both [68Ga]Ga-PSMA-11 and [18F]AlF-PSMA-11 in mice bearing PSMA-positive tumor xenografts. Uptake was assessed by PET/CT at 1, 2 and 4 h post-injection, and by ex vivo meas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::090d53b0235f8a2865d1f1727d3868c6
https://doi.org/10.1016/j.apradiso.2020.109164

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Efficient radiosynthesis of a [18F]-phosphonium salt containing closo-carborane

Autor: Daniel E. Morrison, Michael Kassiou, Joseph A. Ioppolo, Nicolas Giboureau, Louis M. Rendina, Mohan M. Bhadbhade

An efficient synthesis of an 18F-labelled phosphonium salt containing closo-carborane is described. The preparation of this salt was attempted using both single-step and two-step protocols, with greater success found for the latter. An X-ray structur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e34fd9504d980e1af7083e64e92c5a
https://hdl.handle.net/2123/21603

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Water-soluble phosphonium salts containing 1,12-dicarba-closo-dodecaborane(12)

Autor: Michael Kassiou, Louis M. Rendina, Joseph A. Ioppolo

Publikováno v: Tetrahedron Letters. 50:6457-6461

The preparation of new water-soluble phosphonium salts containing 1,12-dodeca-closo-dodecaborane(12) (closo-1,12-carborane) for potential use as tumor-targeting agents in Boron Neutron Capture Therapy (BNCT) is described.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26d5aa1e535593e72cd8c1300d43b795
https://doi.org/10.1016/j.tetlet.2009.08.112

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New functionalized mercaptoundecahydrododecaborate derivatives for potential application in boron neutron capture therapy: synthesis, characterization and dynamic visualization in cells

Autor: Afaf R. Genady, Joseph A. Ioppolo, Mohamed E. El-Zaria, Mohamed M. Azaam

Publikováno v: European journal of medicinal chemistry. 93

A series of mercaptoundecahydrododecaborate (B 12 H 11 SH 2− , BSH) bearing mono- and dicarboxyalkyl derivatives was prepared, characterized, and their reactivity towards amidation and esterification in DMF was evaluated. Symmetrical alkylation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b789e06f227292598264ce3059ef04f1
https://pubmed.ncbi.nlm.nih.gov/25748122

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The first indoleamine-2,3-dioxygenase-1 (IDO1) inhibitors containing carborane

Autor: Joseph A. Ioppolo, Jennifer Ong, Jason R. Smith, Joanne F. Jamie, John H. Reed, Fatiah Issa, David E. Hibbs, Jan Kahlert, Christopher J.D. Austin, Louis M. Rendina

Indoleamine-2,3-dioxygenase-1 (IDO1) is a critical immunoregulatory enzyme responsible for the metabolism of tryptophan during inflammation and disease. Based upon a pyranonaphthoquinone framework, the first examples of indoleamine-2,3-dioxygenase-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96972ecbbe8ba8809040679ced030f47
https://hdl.handle.net/2123/21598

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High yielding synthesis of carboranes under mild reaction conditions using a homogeneous silver(I) catalyst: direct evidence of a bimetallic intermediate

Autor: John F. Valliant, Joseph A. Ioppolo, Afaf R. Genady, Mohamed E. El-Zaria, James McNulty, Kunal Keskar

Publikováno v: Angewandte Chemie (International ed. in English). 53(20)

Methods used to prepare functionalized carboranes generally require heating to high temperatures, and thus limits the range of derivatives which can be prepared directly from alkynes. We show here that by using a homogeneous silver(I) catalyst it is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ccc67db5e7e288ca866d2a4864629d8
https://pubmed.ncbi.nlm.nih.gov/24700630

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