Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Joseph A. Guarnieri"'
Autor:
Giada Corti, JangKeun Kim, Francisco J. Enguita, Joseph W. Guarnieri, Lawrence I. Grossman, Sylvain V. Costes, Matias Fuentealba, Ryan T. Scott, Andrea Magrini, Lauren M. Sanders, Kanhaiya Singh, Chandan K. Sen, Cassandra M. Juran, Amber M. Paul, David Furman, Jean Calleja-Agius, Christopher E. Mason, Diego Galeano, Massimo Bottini, Afshin Beheshti
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-22 (2024)
Abstract In the era of renewed space exploration, comprehending the effects of the space environment on human health, particularly for deep space missions, is crucial. While extensive research exists on the impacts of spaceflight, there is a gap rega
Externí odkaz:
https://doaj.org/article/2fb443a48dab4d80aae577d65caefa4a
Autor:
Nadia Houerbi, JangKeun Kim, Eliah G. Overbey, Richa Batra, Annalise Schweickart, Laura Patras, Serena Lucotti, Krista A. Ryon, Deena Najjar, Cem Meydan, Namita Damle, Christopher Chin, S. Anand Narayanan, Joseph W. Guarnieri, Gabrielle Widjaja, Afshin Beheshti, Gabriel Tobias, Fanny Vatter, Jeremy Wain Hirschberg, Ashley Kleinman, Evan E. Afshin, Matthew MacKay, Qiuying Chen, Dawson Miller, Aaron S. Gajadhar, Lucy Williamson, Purvi Tandel, Qiu Yang, Jessica Chu, Ryan Benz, Asim Siddiqui, Daniel Hornburg, Steven Gross, Bader Shirah, Jan Krumsiek, Jaime Mateus, Xiao Mao, Irina Matei, Christopher E. Mason
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract As spaceflight becomes more common with commercial crews, blood-based measures of crew health can guide both astronaut biomedicine and countermeasures. By profiling plasma proteins, metabolites, and extracellular vesicles/particles (EVPs) fr
Externí odkaz:
https://doaj.org/article/247c896f001a435c9ecc55bb10c04051
Autor:
J. Tyson McDonald, JangKeun Kim, Lily Farmerie, Meghan L. Johnson, Nidia S. Trovao, Shehbeel Arif, Keith Siew, Sergey Tsoy, Yaron Bram, Jiwoon Park, Eliah Overbey, Krista Ryon, Jeffrey Haltom, Urminder Singh, Francisco J. Enguita, Victoria Zaksas, Joseph W. Guarnieri, Michael Topper, Douglas C. Wallace, Cem Meydan, Stephen Baylin, Robert Meller, Masafumi Muratani, D. Marshall Porterfield, Brett Kaufman, Marcelo A. Mori, Stephen B. Walsh, Dominique Sigaudo-Roussel, Saida Mebarek, Massimo Bottini, Christophe A. Marquette, Eve Syrkin Wurtele, Robert E. Schwartz, Diego Galeano, Christopher E. Mason, Peter Grabham, Afshin Beheshti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Our previous research revealed a key microRNA signature that is associated with spaceflight that can be used as a biomarker and to develop countermeasure treatments to mitigate the damage caused by space radiation. Here, we expand on this wo
Externí odkaz:
https://doaj.org/article/0649faa161fd46558b42240dde0a9327
Autor:
Yi Zhu, Neha Kohli, Anthony Young, Malkah Sheldon, Jani Coni, Meera Rajasekaran, Lozen Robinson, Rea Chroneos, Shaipreeah Riley, Joseph W. Guarnieri, Joshua Jose, Nisha Patel, Douglas C. Wallace, Shihong Li, Hsiaoju Lee, Robert H. Mach, Meagan J. McManus
Publikováno v:
Antioxidants, Vol 13, Iss 10, p 1226 (2024)
Although the precise molecular mechanisms responsible for neuronal death and motor dysfunction in late-onset Parkinson’s disease (PD) are unknown, evidence suggests that mitochondrial dysfunction and neuroinflammation occur early, leading to a coll
Externí odkaz:
https://doaj.org/article/05f0dc0c9db44296bebf93cfdbde983b
Autor:
Giada Corti, JangKeun Kim, Francisco J. Enguita, Joseph W. Guarnieri, Lawrence I. Grossman, Sylvain V. Costes, Matias Fuentealba, Ryan T. Scott, Andrea Magrini, Lauren M. Sanders, Kanhaiya Singh, Chandan K. Sen, Cassandra M. Juran, Amber M. Paul, David Furman, Jean Calleja-Agius, Christopher E. Mason, Diego Galeano, Massimo Bottini, Afshin Beheshti
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/a37e0c0e8ae54221bf8b752cf4d48f77
Autor:
Joseph W. Guarnieri, Jeffrey A. Haltom, Yentli E. Soto Albrecht, Timothy Lie, Arnold Z. Olali, Gabrielle A. Widjaja, Sujata S. Ranshing, Alessia Angelin, Deborah Murdock, Douglas C. Wallace
Publikováno v:
Pharmacological Research, Vol 204, Iss , Pp 107170- (2024)
To determine the effects of SARS-CoV-2 infection on cellular metabolism, we conducted an exhaustive survey of the cellular metabolic pathways modulated by SARS-CoV-2 infection and confirmed their importance for SARS-CoV-2 propagation by cataloging th
Externí odkaz:
https://doaj.org/article/8d5644fc539c45289de88eb23eb672c6
Autor:
Joseph W. Guarnieri, Alessia Angelin, Deborah G. Murdock, Patrick Schaefer, Prasanth Portluri, Timothy Lie, Jessica Huang, Douglas C. Wallace
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundCompared to healthy controls, severe COVID19 patients display increased levels of activated NLRP3-inflammasome (NLRP3-I) and interleukin (IL)-1β. SARS-CoV-2 encodes viroporin proteins E and Orf3a(2-E+2-3a) with homologs to SARS-CoV-1, 1-E+
Externí odkaz:
https://doaj.org/article/a72620b0a8fe4e418e304ad3947267a0
Autor:
J. Tyson McDonald, Francisco J. Enguita, Deanne Taylor, Robert J. Griffin, Waldemar Priebe, Mark R. Emmett, Mohammad M. Sajadi, Anthony D. Harris, Jean Clement, Joseph M. Dybas, Nukhet Aykin-Burns, Joseph W. Guarnieri, Larry N. Singh, Peter Grabham, Stephen B. Baylin, Aliza Yousey, Andrea N. Pearson, Peter M. Corry, Amanda Saravia-Butler, Thomas R. Aunins, Sadhana Sharma, Prashant Nagpal, Cem Meydan, Jonathan Foox, Christopher Mozsary, Bianca Cerqueira, Viktorija Zaksas, Urminder Singh, Eve Syrkin Wurtele, Sylvain V. Costes, Gustavo Gastão Davanzo, Diego Galeano, Alberto Paccanaro, Suzanne L. Meinig, Robert S. Hagan, Natalie M. Bowman, Matthew C. Wolfgang, Selin Altinok, Nicolae Sapoval, Todd J. Treangen, Pedro M. Moraes-Vieira, Charles Vanderburg, Douglas C. Wallace, Jonathan C. Schisler, Christopher E. Mason, Anushree Chatterjee, Robert Meller, Afshin Beheshti, Shannon M. Wallet, Robert Maile, Jason R. Mock, Jose L. Torres-Castillo, Miriya K. Love, Will Lovell, Colleen Rice, Olivia Mitchem, Dominique Burgess, Jessica Suggs, Jordan Jacobs
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109839- (2021)
Summary: MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation that have a major impact on many diseases and provide an exciting avenue toward antiviral therapeutics. From patient transcriptomic data, we determ
Externí odkaz:
https://doaj.org/article/86972322eb3c4fa78fa77d4ae3931268
Autor:
David A. Jamison, S. Anand Narayanan, Nídia S. Trovão, Joseph W. Guarnieri, Michael J. Topper, Pedro M. Moraes-Vieira, Viktorija Zaksas, Keshav K. Singh, Eve Syrkin Wurtele, Afshin Beheshti
Publikováno v:
European Journal of Human Genetics. 30:889-898
COVID-19, the disease caused by SARS-CoV-2, has claimed approximately 5 million lives and 257 million cases reported globally. This virus and disease have significantly affected people worldwide, whether directly and/or indirectly, with a virulent pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be1372921e0404f447888ab485481538
https://doi.org/10.1038/s41431-022-01108-8
https://doi.org/10.1038/s41431-022-01108-8
Autor:
Joseph W. Guarnieri, Alessia Angelin, Deborah G. Murdock, Prasanth Portluri, Timothy Lie, Douglas C. Wallace
SUMMARYCytokine storm precipitated by activation of the host innate immune defenses is a major cause of COVID19 death. To elucidate how SARS-CoV-2 initiates this inflammatory process, we studied viroporin proteins E and Orf3a (2-E+2-3a). Expression o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0232a6735ecaba01704cf0894ed7dac3
https://doi.org/10.1101/2022.02.19.481139
https://doi.org/10.1101/2022.02.19.481139
