Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Joseph A. Gredell"'
Autor:
S. Patrick Walton, Joseph A. Gredell, Erin B. Vogel, Amanda P. Malefyt, Christina Chan, R. Chauncey Splichal, Milton R. Smith, Georgina Comiskey
Publikováno v:
Nucleic Acid Ther
The development of delivery vehicles for small interfering RNAs (siRNAs) remains a bottleneck to widespread clinical use. Cationic polymers represent an important class of potential delivery vehicles. In this study, we used alkyne-azide click chemist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cffce87d3ff847a3819bb10ae733c2b
https://pubmed.ncbi.nlm.nih.gov/32749923
https://pubmed.ncbi.nlm.nih.gov/32749923
Publikováno v:
FEBS Journal. 277:4806-4813
The discovery of RNA interference (RNAi) generated considerable interest in developing short interfering RNAs (siRNAs) for understanding basic biology and as the active agents in a new variety of therapeutics. Early studies showed that selecting an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29cc5b8b0d8e18bd9f95c8b3ecac307f
https://doi.org/10.1111/j.1742-4658.2010.07903.x
https://doi.org/10.1111/j.1742-4658.2010.07903.x
Publikováno v:
Biochemistry. 49:3148-3155
RNA interference (RNAi) is a means of enacting specific silencing of the expression of a target gene (1, 2). The pathway can be initiated by long double-stranded RNAs (dsRNAs) or pre-microRNAs (pre-miRNAs) processed by the ribonuclease III family enz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2b79937d0b4b7cd7d0f5242d82c649
https://doi.org/10.1021/bi902189s
https://doi.org/10.1021/bi902189s
Publikováno v:
Biotechnology and Bioengineering. 100:744-755
The selection of active siRNAs is generally based on identifying siRNAs with certain sequence and structural properties. However, the efficiency of RNA interference has also been shown to depend on the structure of the target mRNA, primarily through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dbe4a0c64bbd04c30388e1a19a3867f
https://doi.org/10.1002/bit.21798
https://doi.org/10.1002/bit.21798
Publikováno v:
Biotechnology journal. 7(4)
Nature takes advantage of the malleability of protein and RNA sequence and structure to employ these macromolecules as molecular reporters whose conformation and functional roles depend on the presence of a specific ligand (an "effector" molecule). B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520ef879de1de0b251b1da2c38efd302
https://pubmed.ncbi.nlm.nih.gov/22031507
https://pubmed.ncbi.nlm.nih.gov/22031507
Publikováno v:
The FEBS journal. 277(23)
The discovery of RNA interference (RNAi) generated considerable interest in developing short interfering RNAs (siRNAs) for understanding basic biology and as the active agents in a new variety of therapeutics. Early studies showed that selecting an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1e5631b8f530f439e4e72768383f6ddb
https://pubmed.ncbi.nlm.nih.gov/21078115
https://pubmed.ncbi.nlm.nih.gov/21078115
Publikováno v:
Cell Engineering ISBN: 9789048122448
RNA interference (RNAi) is a recently discovered technique for the directed inhibition of gene expression at the level of the mRNA. Its specificity and potency make it a promising method for manipulating cellular phenotypes in eukaryotic cell lines a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afc7cb2b7da10b0fe5a9531bfa43d941
https://doi.org/10.1007/978-90-481-2245-5_9
https://doi.org/10.1007/978-90-481-2245-5_9
