Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Joseph A. Fix"'
Publikováno v:
Gastroenterology. 154:S-72
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31b655166d87d1e6412a8faf0b06ddd6
https://doi.org/10.1016/s0016-5085(18)30694-2
https://doi.org/10.1016/s0016-5085(18)30694-2
Autor:
Libo Yang, Joseph A. Fix, Shunsuke Watanabe, Masataka Katsuma, Jinhe Li, Shigeharu Yokohama, James Shunnan Chu
Publikováno v:
Pharmaceutical Research. 20:429-434
Purpose. To test the hypothesis that the onset of drug release in vivo from a unique colon-specific drug delivery system (CODES™) would depend on the colonic availability rate of lactulose. The site specificity of drug release in canine GI tract wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fd91f39eca5329962cc1d48578d4cab
https://doi.org/10.1023/a:1022660305931
https://doi.org/10.1023/a:1022660305931
Publikováno v:
International Journal of Pharmaceutics. 235:1-15
The necessity and advantages of colon-specific drug delivery systems have been well recognized and documented. In the past, the primary approaches to obtain colon-specific delivery achieved limited success and included prodrugs, pH- and time-dependen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672299d6e6dc0d5e0359e8609060c748
https://doi.org/10.1016/s0378-5173(02)00004-2
https://doi.org/10.1016/s0378-5173(02)00004-2
Publikováno v:
Pharmaceutical Science & Technology Today. 3:138-145
Despite disadvantages, oral drug delivery remains the preferred route of drug delivery. Novel technologies with improved performance, patient compliance, and enhanced quality have emerged in the recent past. Oral fast-dispersing dosage forms, three-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dec7977e1772cb121fb9ab7a5ebabdd3
https://doi.org/10.1016/s1461-5347(00)00247-9
https://doi.org/10.1016/s1461-5347(00)00247-9
Autor:
Peter E. Daddona, Mary Broughall, Joseph A. Fix, Anthony C. Chao, Joseph Vu Nguyen, Angelica Griffin
Publikováno v:
International Journal of Pharmaceutics. 191:15-24
Sodium salts of medium-chain fatty acids, sodium caprate (C10) in particular, have been used as absorption-enhancing agents to promote transmucosal drug absorption. In this study, we conducted both in vitro and in vivo experiments to investigate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d92a5b6c00683a61ccc679f65e02598
https://doi.org/10.1016/s0378-5173(99)00213-6
https://doi.org/10.1016/s0378-5173(99)00213-6
Autor:
Joseph Vu Nguyen, Joseph A. Fix, Mary Broughall, Joanne Recchia, Anthony C. Chao, Peter E. Daddona, Charlotte R. Kensil
Publikováno v:
Journal of Pharmaceutical Sciences. 87:1395-1399
DS-1, a modified Quillaja saponin, has recently been shown to promote the absorption of insulin and aminoglycoside antibiotics via the ocular and nasal route. The purpose of this study is to investigate the effect of DS-1 on intestinal permeability,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed94d95e202a200bd40b28f0ee511848
https://doi.org/10.1021/js9800735
https://doi.org/10.1021/js9800735
Autor:
Joseph A. Fix
Publikováno v:
Pharmaceutical Research. 13:1760-1764
In spite of significant efforts in academic and commercial laboratories, major breakthroughs in oral peptide and protein formulation have not been achieved. The major barriers to developing oral formulations for peptides and proteins include poor int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99ea5264f267df918550186f9b7d1e83
https://doi.org/10.1023/a:1016008419367
https://doi.org/10.1023/a:1016008419367
Autor:
Paula S. Leppert, Joseph A. Fix
Publikováno v:
Journal of Pharmaceutical Sciences. 83:976-981
The ability to predict in vivo oral absorption potential based on ex vivo screening in an everted intestinal ring model was examined. In vitro drug accumulation in cross sectional rings of everted rat jejunum was determined with 12 compounds whose in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4508a2da91c3d01143ae11650a8350b0
https://doi.org/10.1002/jps.2600830712
https://doi.org/10.1002/jps.2600830712
Autor:
Margot Cortese, Robyn Cargill, Joseph A. Fix, Karen Engle, Lori Coffman, Paula S. Leppert, Colette Krupco, Leilani Cammack
Publikováno v:
Journal of Biomedical Materials Research. 28:713-722
Rats, dogs, sheep, and cattle were implanted subcutaneously with stainless-steel tissue cages. Bolus injections of cefoxitin and ivermectin were administered to the interiors of the tissue cages 11, 32, and 60 days after implantation to simulate puls
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::268a183b769bf9d8b6a62aa82c21c7e8
https://doi.org/10.1002/jbm.820280608
https://doi.org/10.1002/jbm.820280608
Publikováno v:
Journal of Controlled Release. 25:155-162
Release of ivermectin from a crosslinked poly(ortho ester) matrix was studied both in vitro and in vivo in rats and dogs. A total of 32.8% of the loaded drug was covalently bonded to the polymer matrix. The release rate of the drug in vitro was initi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a97a60935234f72edd48781d7b25c2ac
https://doi.org/10.1016/0168-3659(93)90104-d
https://doi.org/10.1016/0168-3659(93)90104-d