Zobrazeno 1 - 10
of 502
pro vyhledávání: '"Joseph A. Fisher"'
Cerebral perfusion metrics calculated directly from a hypoxia-induced step change in deoxyhemoglobin
Autor:
James Duffin, Ece Su Sayin, Olivia Sobczyk, Julien Poublanc, David J. Mikulis, Joseph A. Fisher
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Resting cerebral perfusion metrics can be calculated from the MRI ΔR2* signal during the first passage of an intravascular bolus of a Gadolinium-based contrast agent (GBCA), or more recently, a transient hypoxia-induced change in the concen
Externí odkaz:
https://doaj.org/article/12568e23cccb48909bbdc57866bedd4b
Autor:
Vittorio Stumpo, Ece Su Sayin, Jacopo Bellomo, Olivia Sobczyk, Christiaan Hendrik Bas van Niftrik, Martina Sebök, Michael Weller, Luca Regli, Zsolt Kulcsár, Athina Pangalu, Andrea Bink, James Duffin, David D. Mikulis, Joseph A. Fisher, Jorn Fierstra
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Background: Transient hypoxia-induced deoxyhemoglobin (dOHb) has recently been shown to represent a comparable contrast to gadolinium-based contrast agents for generating resting perfusion measures in healthy subjects. Here, we investigate the feasib
Externí odkaz:
https://doaj.org/article/5451cc7dece8445ebdfc3670de04d191
Autor:
Ece Su Sayin, Olivia Sobczyk, Julien Poublanc, David J. Mikulis, Joseph A. Fisher, James Duffin
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: Use of contrast in determining hemodynamic measures requires the deconvolution of an arterial input function (AIF) selected over a voxel in the middle cerebral artery to calculate voxel wise perfusion metrics. Transfer function analysis
Externí odkaz:
https://doaj.org/article/7301816458004c009d79cb51b09b77e4
Autor:
Jacob Benjamin Schulman, Ece Su Sayin, Angelica Manalac, Julien Poublanc, Olivia Sobczyk, James Duffin, Joseph A. Fisher, David Mikulis, Kâmil Uludağ
Publikováno v:
Frontiers in Neuroimaging, Vol 2 (2023)
IntroductionDynamic susceptibility contrast (DSC) MRI allows clinicians to determine perfusion parameters in the brain, such as cerebral blood flow, cerebral blood volume, and mean transit time. To enable quantification, susceptibility changes can be
Externí odkaz:
https://doaj.org/article/ce71c70ddd594426a2ccf68897f08e29
Autor:
Alex A. Bhogal, Ece Su Sayin, Julien Poublanc, James Duffin, Joseph A. Fisher, Olivia Sobcyzk, David J. Mikulis
Publikováno v:
NeuroImage, Vol 261, Iss , Pp 119523- (2022)
Cerebral blood arrival and tissue transit times are sensitive measures of the efficiency of tissue perfusion and can provide clinically meaningful information on collateral blood flow status. We exploit the arterial blood oxygen level dependent (BOLD
Externí odkaz:
https://doaj.org/article/a356a5d8dec340f594f0363498ac4fbf
Autor:
Ece Su Sayin, Olivia Sobczyk, Julien Poublanc, David J. Mikulis, Joseph A. Fisher, Kevin H. M. Kuo, James Duffin
Publikováno v:
Physiological Reports, Vol 10, Iss 19, Pp n/a-n/a (2022)
Abstract In patients with sickle cell disease (SCD), the delivery of oxygen to the brain is compromised by anemia, abnormal rheology, and steno‐occlusive vascular disease. Successful compensation depends on an increase in oxygen supply such as that
Externí odkaz:
https://doaj.org/article/86e3a224da09422f91535b9ccb790851
Autor:
Ece Su Sayin, Olivia Sobczyk, Julien Poublanc, David J. Mikulis, Joseph A. Fisher, Kevin H. M. Kuo, James Duffin
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
In patients with sickle cell disease (SCD) the delivery of oxygen to the brain is compromised by anemia, abnormal rheology, and steno-occlusive vascular disease. Meeting demands for oxygen delivery requires compensatory features of brain perfusion. T
Externí odkaz:
https://doaj.org/article/461cb4c9f69f425dacff27abf7daba42
Autor:
Olivia Sobczyk, Jorn Fierstra, Lakshmikumar Venkatraghavan, Julien Poublanc, James Duffin, Joseph A. Fisher, David J. Mikulis
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
An increase in arterial PCO2 is the most common stressor used to increase cerebral blood flow for assessing cerebral vascular reactivity (CVR). That CO2 is readily obtained, inexpensive, easy to administer, and safe to inhale belies the difficulties
Externí odkaz:
https://doaj.org/article/c4e850a578194c928da2be1cee80e9df
Autor:
Julien Poublanc, Reema Shafi, Olivia Sobczyk, Kevin Sam, Daniel M. Mandell, Lakshmikumar Venkatraghavan, James Duffin, Joseph A. Fisher, David J. Mikulis
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Cerebrovascular reactivity (CVR) is defined as the change in cerebral blood flow induced by a change in a vasoactive stimulus. CVR using BOLD MRI in combination with changes in end-tidal CO2 is a very useful method for assessing vascular performance.
Externí odkaz:
https://doaj.org/article/269635b053af44ee9aacd979b4139742
Autor:
Olivia Sobczyk, Ece Su Sayin, Kevin Sam, Julien Poublanc, James Duffin, Joseph A. Fisher, David J. Mikulis
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Cerebrovascular reactivity (CVR) is defined as the ratio of the cerebral blood flow (CBF) response to an increase in a vasoactive stimulus. We used changes in blood oxygenation level-dependent (BOLD) MRI as surrogates for changes of CBF, and standard
Externí odkaz:
https://doaj.org/article/7aa905ba0acf44b7b841db35e967042a