Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Joseph A. Dent"'
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-16 (2018)
Abstract Background Developmental physiology is very sensitive to nutrient availability. For instance, in the nematode Caenorhabditis elegans, newly hatched L1-stage larvae require food to initiate postembryonic development. In addition, larvae arres
Externí odkaz:
https://doaj.org/article/7910f91639084fa3ba8014aaf12b54e1
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138804 (2015)
New compounds are needed to treat parasitic nematode infections in humans, livestock and plants. Small molecule anthelmintics are the primary means of nematode parasite control in animals; however, widespread resistance to the currently available dru
Externí odkaz:
https://doaj.org/article/bb50b715a995452cb0d2ea91a313f5cb
Publikováno v:
PLoS Pathogens, Vol 9, Iss 8, p e1003586 (2013)
Cys-loop ligand-gated ion channels (LGICs) mediate fast ionotropic neurotransmission. They are proven drug targets in nematodes and arthropods, but are poorly characterized in flatworms. In this study, we characterized the anion-selective, non-acetyl
Externí odkaz:
https://doaj.org/article/a233d3aff8dd4063bde55c97eecca554
Autor:
Tanja Starc, Michael P. O'Donnell, Pierre Drapeau, Joseph A. Dent, Laura D. Knogler, Daniel Feingold, Laura A. Nilson
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Organisms use circulating diuretic hormones to control water balance (osmolarity), thereby avoiding dehydration and managing excretion of waste products. The hormones act through G-protein-coupled receptors to activate second messenger systems that i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f0ec6e7eaaed1c485e417d683df0a6
https://doi.org/10.1038/s41598-019-42849-9
https://doi.org/10.1038/s41598-019-42849-9
Publikováno v:
BMC Biology
BMC Biology, Vol 16, Iss 1, Pp 1-16 (2018)
BMC Biology, Vol 16, Iss 1, Pp 1-16 (2018)
Background Developmental physiology is very sensitive to nutrient availability. For instance, in the nematode Caenorhabditis elegans, newly hatched L1-stage larvae require food to initiate postembryonic development. In addition, larvae arrested in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cae8a2e5f41ca22c63a0582bd336be0
https://doi.org/10.1186/s12915-018-0579-3
https://doi.org/10.1186/s12915-018-0579-3
Food perception affects animal physiology in complex ways. We uncoupled the effects of food perception and ingestion in the roundwormC. elegans. Perception was not sufficient to promote development, but larvae exposed to food without ingestion failed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f9fb6556691601f7f4451781cd9d25
Autor:
Ludmel Urdaneta-Marquez, Patrick Janukavicius, Roger K. Prichard, Robin N. Beech, Joseph A. Dent, Seong Han Bae
Publikováno v:
International Journal for Parasitology. 44:1063-1071
Heavy reliance on macrocyclic lactones to treat parasitic nematodes has resulted in the evolution of widespread drug resistance that threatens human and animal health. Management strategies have been proposed that would slow the rise of resistance, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b3802510456a3cbeaabaedbdd92d69a
https://doi.org/10.1016/j.ijpara.2014.08.005
https://doi.org/10.1016/j.ijpara.2014.08.005
Publikováno v:
Journal of Experimental Biology.
Pentameric ligand-gated ion channels (pLGICs) constitute a large protein superfamily in metazoa whose role as neurotransmitter receptors mediating rapid, ionotropic synaptic transmission has been extensively studied. Although the vast majority of pLG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8472e0a418a57cef90ddfe7b2fa77bf8
https://doi.org/10.1242/jeb.141069
https://doi.org/10.1242/jeb.141069
Autor:
James S. McCarthy, Bart J. Currie, Joseph A. Dent, Shelley F. Walton, Deborah C. Holt, Kate E. Mounsey
Publikováno v:
Invertebrate Neuroscience. 7:149-156
Reports of ivermectin resistance in scabies mites raise concerns regarding the sustainability of mass intervention programs for scabies worldwide and for the treatment of crusted scabies. Ligand gated ion channels (LGICs) are the primary targets of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474daa5a64ce41f1cd5bf00e05f686ee
https://doi.org/10.1007/s10158-007-0050-6
https://doi.org/10.1007/s10158-007-0050-6
Publikováno v:
Developmental Neurobiology. 67:189-204
Serotonin (5-hydroxytryptamine: 5HT) is an important neuroactive substance in the model roundworm, Caenorhabditis elegans. Aside from having effects in feeding and egg-laying, 5HT inhibits motility and also modulates several locomotory behaviors, not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7e5f43e19c193010c1c4a0a1c62810
https://doi.org/10.1002/dneu.20340
https://doi.org/10.1002/dneu.20340