Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Joseph A. Cozzitorto"'
Autor:
Jonathan R. Brody, Zhihao Zhuang, Janet A. Sawicki, Jordan M. Winter, Andrew Napper, Matthew Gehrmann, Charles J. Yeo, Agnieska K. Witkiewicz, Joseph A. Cozzitorto, Shruti Lal, Kathy Miller, Yongxing Ai, Qin Liang, Vanessa A. Talbott, Renée M. Tholey, Zoë A. Norris, Yu Peng, Richard A. Burkhart
PDF file - 59K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6065f2d773f29c29792c0beabd9cf72a
https://doi.org/10.1158/1541-7786.22509771.v1
https://doi.org/10.1158/1541-7786.22509771.v1
Autor:
Jonathan R. Brody, Zhihao Zhuang, Janet A. Sawicki, Jordan M. Winter, Andrew Napper, Matthew Gehrmann, Charles J. Yeo, Agnieska K. Witkiewicz, Joseph A. Cozzitorto, Shruti Lal, Kathy Miller, Yongxing Ai, Qin Liang, Vanessa A. Talbott, Renée M. Tholey, Zoë A. Norris, Yu Peng, Richard A. Burkhart
PDF file - 28K, S1. Cell growth in a high USP11 expression cell line (PL5) following siRNA treatment targeting USP11.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56828542c7b6db72d2b4961f3ceb462b
https://doi.org/10.1158/1541-7786.22509774
https://doi.org/10.1158/1541-7786.22509774
Autor:
Jonathan R. Brody, George C. Prendergast, Charles J. Yeo, Jordan M. Winter, Laura Mandik-Nayak, Benjamin E. Leiby, Tatiana Villatoro, Mark Curtis, Theresa P. Yeo, Harish Lavu, Joseph A. Cozzitorto, Kevin O'Hayer, Eric Londin, Kei Nagatomo, James B. DuHadaway, Erika Sutanto-Ward, Alexander J. Muller, Avinoam Nevler
Flow cytometry graphs (black and white line and dot drawing)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a14bdcc0c6fe4d185c9df01a8ff333bb
https://doi.org/10.1158/1078-0432.22474127.v1
https://doi.org/10.1158/1078-0432.22474127.v1
Autor:
Jordan M. Winter, Jonathan R. Brody, Christian M. Metallo, Erin L. Seifert, Eric R. Londin, Charles J. Yeo, Wei Jiang, Joseph A. Cozzitorto, Masaya Jimbo, Saswati N. Chand, Fernando F. Blanco, Cynthia Moffat, Nicole C. Mambelli-Lisboa, Katerina Dukleska, Ali Vaziri-Gohar, Avinoam Nevler, Seth J. Parker, Shruti Lal, Mahsa Zarei
Table S5: Results of RNA sequencing in PDA cell lines (HS-766T and MiaPaCa2) with each modulated by CRISPR/Cas9 to delete HuR expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407575c68ba038659eca4790c467ac6a
https://doi.org/10.1158/0008-5472.22414922
https://doi.org/10.1158/0008-5472.22414922
Autor:
Jordan M. Winter, Jonathan R. Brody, Christian M. Metallo, Erin L. Seifert, Eric R. Londin, Charles J. Yeo, Wei Jiang, Joseph A. Cozzitorto, Masaya Jimbo, Saswati N. Chand, Fernando F. Blanco, Cynthia Moffat, Nicole C. Mambelli-Lisboa, Katerina Dukleska, Ali Vaziri-Gohar, Avinoam Nevler, Seth J. Parker, Shruti Lal, Mahsa Zarei
Cancer aggressiveness may result from the selective pressure of a harsh nutrient-deprived microenvironment. Here we illustrate how such conditions promote chemotherapy resistance in pancreatic ductal adenocarcinoma (PDAC). Glucose or glutamine withdr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fca4173cfff5730bbe12fdcc153e4f7
https://doi.org/10.1158/0008-5472.c.6509120.v1
https://doi.org/10.1158/0008-5472.c.6509120.v1
Autor:
Jonathan R. Brody, Jordan M. Winter, John M. Pascal, Charles J. Yeo, Karen E. Knudsen, Michael J. Pishvaian, Nicole Meisner-Kober, Wei Jiang, Eric Londin, Laura Scolaro, Avinoam Nevler, Joseph A. Cozzitorto, Shruti Lal, Carmella Romeo, Akshay R. Kamath, Matthew J. Schiewer, Mahsa Zarei, Saswati N. Chand
PARG rescue in HuR silenced cells restores PARPi resistance. Small-molecule inhibition of HuR prevents its cytoplasmic accumulation, abrogates PARG mRNA regulation and increases PARPi sensitivity, independent of DDR status.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bceb7e3ef902e2e70ae482b29c4ff897
https://doi.org/10.1158/0008-5472.22416705
https://doi.org/10.1158/0008-5472.22416705
Autor:
Jonathan R. Brody, Jordan M. Winter, John M. Pascal, Charles J. Yeo, Karen E. Knudsen, Michael J. Pishvaian, Nicole Meisner-Kober, Wei Jiang, Eric Londin, Laura Scolaro, Avinoam Nevler, Joseph A. Cozzitorto, Shruti Lal, Carmella Romeo, Akshay R. Kamath, Matthew J. Schiewer, Mahsa Zarei, Saswati N. Chand
Doxycycline induction of HuR silencing in MIA PaCa-2 cells (sh290) downregulates PARG expression in vitro and tumor growth in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27cbca6f975a7e2018f6b0b818443577
https://doi.org/10.1158/0008-5472.22416702.v1
https://doi.org/10.1158/0008-5472.22416702.v1
Autor:
Jonathan R. Brody, Jordan M. Winter, John M. Pascal, Charles J. Yeo, Karen E. Knudsen, Michael J. Pishvaian, Nicole Meisner-Kober, Wei Jiang, Eric Londin, Laura Scolaro, Avinoam Nevler, Joseph A. Cozzitorto, Shruti Lal, Carmella Romeo, Akshay R. Kamath, Matthew J. Schiewer, Mahsa Zarei, Saswati N. Chand
HuR silencing results in downregulation of PARG expression, which prevents efficient removal of PAR polymers with or without PARPi stress. Expression and function of other PAR removing enzymes is not affected with HuR silencing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d30a8c36dd805071ddb659360d7ff19
https://doi.org/10.1158/0008-5472.22416711
https://doi.org/10.1158/0008-5472.22416711
Autor:
Jonathan R. Brody, Jordan M. Winter, John M. Pascal, Charles J. Yeo, Karen E. Knudsen, Michael J. Pishvaian, Nicole Meisner-Kober, Wei Jiang, Eric Londin, Laura Scolaro, Avinoam Nevler, Joseph A. Cozzitorto, Shruti Lal, Carmella Romeo, Akshay R. Kamath, Matthew J. Schiewer, Mahsa Zarei, Saswati N. Chand
HuR directly binds and regulates poly-ADP ribose glycohydrolase mRNA expression particularly under PARPi stress, but doesn't affect expression of other PAR polymerases or hydrolyzing enzymes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::391bd3a9966c19991c83d520996223e4
https://doi.org/10.1158/0008-5472.22416717.v1
https://doi.org/10.1158/0008-5472.22416717.v1
Autor:
Jonathan R. Brody, George C. Prendergast, Charles J. Yeo, Jordan M. Winter, Laura Mandik-Nayak, Benjamin E. Leiby, Tatiana Villatoro, Mark Curtis, Theresa P. Yeo, Harish Lavu, Joseph A. Cozzitorto, Kevin O'Hayer, Eric Londin, Kei Nagatomo, James B. DuHadaway, Erika Sutanto-Ward, Alexander J. Muller, Avinoam Nevler
Purpose:Heritable genetic variations can affect the inflammatory tumor microenvironment, which can ultimately affect cancer susceptibility and clinical outcomes. Recent evidence indicates that IDO2, a positive modifier in inflammatory disease models,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6436d7fc32241df84282af6cf83819d0
https://doi.org/10.1158/1078-0432.c.6528692.v1
https://doi.org/10.1158/1078-0432.c.6528692.v1