Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Joseph A. Bilotta"'
Autor:
Thomas P. Stratton, Patricia Soteropoulos, Joel S. Freundlich, Xin Wang, Hsin Pin Ho, Srinivasan Kandasamy, Seema Hussain, Alejandro Davila-Pagan, Ravindra Jadhav, Daigo Inoyama, Nisha Mittal, Eric Singleton, Sean Ekins, Véronique Dartois, Richard Pottorf, Yong Mo Ahn, Pradeep Kumar, Riccardo Russo, Joseph A. Bilotta, Matthew D. Zimmerman, Courtney Grady, Nancy D. Connell, Thomas J. Kim, Steve D. Paget, Steven Park, Shao-Gang Li
Publikováno v:
Cell Chem Biol
Summary The triazine antitubercular JSF-2019 was of interest due to its in vitro efficacy and the nitro group shared with the clinically relevant delamanid and pretomanid. JSF-2019 undergoes activation requiring F420H2 and one or more nitroreductases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef40c52dd7e436750e1c5e66319649f9
https://doi.org/10.1016/j.chembiol.2019.10.010
https://doi.org/10.1016/j.chembiol.2019.10.010
Autor:
Rebecca Taub, Robert Alan Goodnow, Lida Qi, Joseph Anthony Bilotta, Sherrie Lynn Pietranico-Cole, Yonglin Ren, Cheryl Spence, Jefferson Wright Tilley, Baolian Liu, Sung-Sau So, Kevin Richard Guertin, Karin Conde-Knape, Matthew Michael Hamilton, Nancy-Ellen Haynes, Kshitij Chhabilbhai Thakkar, Catherine Zwingelstein, Nathan Robert Scott, Paul Gillespie, Michael Paul Myers, Nader Fotouhi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2707-2711
Starting from screening hit, (4S,7R)-1,7,8,8-tetramethyl-2-phenyl-1,2,4,5,6,7-hexahydro-4,7-methano-indazol-3-one (7), we optimized the potency and pharmacokinetic properties. This led to the identification of compounds with good in vivo activity in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a633bbb07d24cb3c7b6963f9c8c2b89d
https://doi.org/10.1016/j.bmcl.2014.04.049
https://doi.org/10.1016/j.bmcl.2014.04.049
Autor:
Susan Salamone, Steven Tregay, Brian I. Bliss, Michael P. Trova, Simon Haydar, Joseph Anthony Bilotta, Luis Alicea, Patricia Snider, Matthew P. Rainka, R. Jason Herr, Xiaozhang Zheng, Denise Peace, Thuy Nguyen Duong, Keith D. Barnes, Travis Benanti, Thomas D. Friedrich, Matthew R. Johnson, Mark Bielaska, Yu Hui, John M. Lehman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6613-6617
The introduction of an aryl ring onto the 4-position of the C-6 benzyl amino group of the Cdk inhibitor roscovitine (2), maintained the potent Cdk inhibition demonstrated by roscovitine (2) as well as greatly improving the antiproliferative activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc9ed62ae30c61b43e5febf5164cc35
https://doi.org/10.1016/j.bmcl.2009.10.011
https://doi.org/10.1016/j.bmcl.2009.10.011
Publikováno v:
Journal of Urology. 44:358-366
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de0c382f23716cbd7d6cd4109157a6e1
https://doi.org/10.1016/s0022-5347(17)71280-3
https://doi.org/10.1016/s0022-5347(17)71280-3