Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Joseph A. Abramite"'
Publikováno v:
Organic Letters. 17:5196-5199
The selective alkyl lithium-induced ring opening of 1,3-di-isopropylsilylenes is described. The reaction affords a differentially substituted 1,3-diol bearing a silane that resides at the oxygen in the more sterically demanding position. The reaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4229c4e6bf40998d4e88b6d21f48afd7
https://doi.org/10.1021/acs.orglett.5b02529
https://doi.org/10.1021/acs.orglett.5b02529
Autor:
Daniel P. Uccello, Jeremy T. Starr, Matthew Merrill Hayward, R. Scott Obach, Mark C. Noe, Adam M. Gilbert, Justin I. Montgomery, Mark Edward Flanagan, Veerabahu Shanmugasundaram, Dennis P. Anderson, Ann Aulabaugh, Ye Che, Matthew Frank Brown, Michael J. Shapiro, Chao Li, Tim F. Ryder, Stacey R. Oppenheimer, Laurence Philippe, Gregory S. Walker, Yan Wu, Brandon P. Schuff, Joseph A. Abramite, Jinshan M. Chen, Justin G. Stroh, Upendra P. Dahal
Publikováno v:
Journal of Medicinal Chemistry. 57:10072-10079
Interest in drugs that covalently modify their target is driven by the desire for enhanced efficacy that can result from the silencing of enzymatic activity until protein resynthesis can occur, along with the potential for increased selectivity by ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63f9459b6f272dc5eca40673816be92
https://doi.org/10.1021/jm501412a
https://doi.org/10.1021/jm501412a
Autor:
Magee Thomas Victor, Thuy-Trinh Nguyen, Joseph A. Abramite, Yue Shen, Jian Lin, Jiri Aubrecht, Fadia Dib-Hajj, Jeremy T. Starr, Alita A. Miller, Matthew Frank Brown, Shawn H. MacVane, Michael D. Huband, Li Zhang, Karl Granskog, Bryan Li, Jinshan Michael Chen, James M. McKim, John P. O'Donnell, Karen L. Leach, Paul C. Wilga, David P. Nicolau, Sandra P. McCurdy, Mark Edward Flanagan, Antonia F. Stepan, Andrew P. Tomaras, Mark C. Noe, Michael Kuhn, Scott B. Seibel, Rebecca Irvine, Jinfeng Xu, David C. Ackley, David R. Luke, Jared L. Crandon, Joel R. Hardink, Andrew Butler
Publikováno v:
Journal of Medicinal Chemistry. 56:5079-5093
We report novel polymyxin analogues with improved antibacterial in vitro potency against polymyxin resistant recent clinical isolates of Acinetobacter baumannii and Pseudomonas aeruginosa . In addition, a human renal cell in vitro assay (hRPTEC) was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e495f860c984ae946db4940511966812
https://doi.org/10.1021/jm400416u
https://doi.org/10.1021/jm400416u
Publikováno v:
ChemInform. 47
The selective alkyl lithium-induced ring opening of 1,3-di-isopropylsilylenes is described. The reaction affords a differentially substituted 1,3-diol bearing a silane that resides at the oxygen in the more sterically demanding position. The reaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1914f96d4458dd797911bbd9a698e8e9
https://doi.org/10.1002/chin.201613038
https://doi.org/10.1002/chin.201613038
Autor:
Lisa Mullins, Daniel P. Uccello, Justin I. Montgomery, Ye Che, John P. O'Donnell, Mark S. Plummer, Joseph A. Abramite, Seung Won Chung, Loren M. Price, Mark C. Noe, Laura A. McAllister, Rose Barham, Mark J. Mitton-Fry, Andrew P. Tomaras, Usa Reilly, Matthew Frank Brown, Jinshan M. Chen, Joseph Penzien, Carol A. Menard, Veerabahu Shanmugasundaram, Robert M. Oliver
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6832-6838
The synthesis and antibacterial activity of heterocyclic methylsulfone hydroxamates is presented. Compounds in this series are potent inhibitors of the LpxC enzyme, a key enzyme involved in the production of lipopolysaccharide (LPS) found in the oute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5698632622184881fc9d9e040335da17
https://doi.org/10.1016/j.bmcl.2012.09.058
https://doi.org/10.1016/j.bmcl.2012.09.058
Autor:
Tarek Sammakia, Joseph A. Abramite
Publikováno v:
Organic Letters. 9:2103-2106
An intramolecular version of the Yamamoto vinylogous aldol reaction, a method that employs the bulky Lewis acid ATPH to control the site of aldolization, is described. This macrocyclization process is effective for the construction of 10-, 12-, and 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b697c380d0ff32126f7b515f273018
https://doi.org/10.1021/ol0704901
https://doi.org/10.1021/ol0704901
Autor:
Matthew David Doroski, Joel T. Arcari, Mark S. Plummer, Andrea Marra, Thomas M. Harris, Justin I. Montgomery, Usa Reilly, Carol A. Menard, Michael D. Huband, Anthony Marfat, Jinshan Michael Chen, Christy Thoma, Karen L. Leach, John P. O'Donnell, Seung Won Chung, Loren M. Price, Joseph A. Abramite, Charlene R. Desbonnet, Eric B. McElroy, Veerabahu Shanmugasundaram, Michael Melnick, Shenping Liu, Matthew Frank Brown, Mark C. Noe, Joseph S. Warmus, Juntyma J. Engtrakul, Daniel P. Uccello, Donn G. Wishka, Robert M. Oliver, Rose Barham, Joseph Penzien, Jonathan L. Doty, John D. Knafels, Ye Che, Lisa Mullins, Elizabeth M. Collantes
Publikováno v:
Journal of medicinal chemistry. 55(2)
In this paper, we present the synthesis and SAR as well as selectivity, pharmacokinetic, and infection model data for representative analogues of a novel series of potent antibacterial LpxC inhibitors represented by hydroxamic acid 1a.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdcf3eac90ca18e20f4de1258188335d
https://pubmed.ncbi.nlm.nih.gov/22175825
https://pubmed.ncbi.nlm.nih.gov/22175825
The use of the intramolecular vinylogous aldol reaction for the preparation of an advanced intermediate for the synthesis of peloruside A is described. The reaction was applied to compound 19 and proceeds in high yield and good levels of diastereosel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ba3f782ded27eb3cdd6c556a92fa6d
https://europepmc.org/articles/PMC3272878/
https://europepmc.org/articles/PMC3272878/
Autor:
Seung Won Chung, Laura A. McAllister, Mark S. Plummer, Joseph A. Abramite, Joel T. Arcari, Jianmin Sun, Yue Shen, Loren M. Price, Justin I. Montgomery, Daniel P. Uccello, Robert M. Oliver
Publikováno v:
Organic letters. 13(19)
An efficient method was developed for the synthesis of 2-methylene-4-substituted ethyl butyrates via cyclopropyl opening followed by a Wittig reaction. The desired products were formed in a two-step, one-pot reaction sequence. Alternatively, the key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b56b03a6dfee386bab4045d70bb2f2
https://pubmed.ncbi.nlm.nih.gov/21910461
https://pubmed.ncbi.nlm.nih.gov/21910461
Autor:
Dewain K. Garner, Hyeon K. Kim, Zhilin Wang, Steven K Ma, Joseph A. Abramite, Zijian Guo, James R. Carey, Yi Lu, Thomas D. Pfister
Publikováno v:
Journal of the American Chemical Society. 126(35)
Introducing nonnative metal ions or metal-containing prosthetic groups into a protein can dramatically expand the repertoire of its functionalities and thus its range of applications. Particularly challenging is the control of substrate-binding and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5fc46d6e908c8e11f2e0a7bb647e4e
https://pubmed.ncbi.nlm.nih.gov/15339144
https://pubmed.ncbi.nlm.nih.gov/15339144