Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Joseph A Willson"'
Autor:
Eleanor W. Lee, Greig S. Torpey, Joseph A Willson, Timothy D. Warner, Sarah R. Walmsley, Melissa V. Chan, J K Baillie, Alfred Arthur Roger Thompson, Jason M. Young, Christopher J Graham, Gordon G. Paterson, Rebecca C. Dru
Publikováno v:
Thrombosis and Haemostasis
Paterson, G G, Young, J M, Willson, J A, Graham, C J, Dru, R C, Lee, E W, Torpey, G S, Walmsley, S, Chan, M V, Warner, T D, Baillie, K & Roger Thompson, A A 2019, ' Hypoxia modulates platelet purinergic signalling pathways ', Thrombosis and Haemostasis . https://doi.org/10.1055/s-0039-3400305
Paterson, G G, Young, J M, Willson, J A, Graham, C J, Dru, R C, Lee, E W, Torpey, G S, Walmsley, S, Chan, M V, Warner, T D, Baillie, K & Roger Thompson, A A 2019, ' Hypoxia modulates platelet purinergic signalling pathways ', Thrombosis and Haemostasis . https://doi.org/10.1055/s-0039-3400305
Background Hypoxia resulting from ascent to high-altitude or pathological states at sea level is known to increase platelet reactivity. Previous work from our group has suggested that this may be adenosine diphosphate (ADP)-specific. Given the clinic
Autor:
Patrícia Coelho, Pranvera Sadiku, Alex von Kriegsheim, Leila Reyes, David H. Dockrell, Robert Grecian, Jordi Duran, Christopher J Graham, Simone Arienti, Abel Acosta-Sanchez, Veronica M. Dardé, Privjyot Jheeta, Ananda S. Mirchandani, Gordon G. Paterson, A. A. Roger Thompson, David Sammut, Tyler Morrison, Martin A. Bewley, Ailing Zhang, Joseph A Willson, Massimiliano Mazzone, Kenneth Baillie, Moira K. B. Whyte, Tobias Griessler, Sarah R. Walmsley, Emily R. Watts, Peter Carmeliet, Jessie-May Morgan, Eilise M. Ryan, John P. Thomson, Manuel A. Sanchez Garcia, Bart Ghesquière, Joan J. Guinovart, Richard R. Meehan, Gio Rodriguez-Blanco, Jason M. Young
Publikováno v:
Sadiku, P, Willson, J A, Ryan, E M, Sammut, D, Coelho, P, Watts, E R, Grecian, R, Young, J M, Bewley, M, Arienti, S, Mirchandani, A S, Sanchez Garcia, M A, Morrison, T, Zhang, A, Reyes, L, Griessler, T, Jheeta, P, Paterson, G G, Graham, C J, Thompson, J P, Baillie, K, Thompson, A A R, Morgan, J-M, Acosta-Sanchez, A, Dardé, V M, Duran, J, Guinovart, J J, Rodriguez-Blanco, G, Von Kriegsheim, A, Meehan, R R, Mazzone, M, Dockrell, D H, Ghesquiere, B, Carmeliet, P, Whyte, M K B & Walmsley, S R 2021, ' Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis ', Cell Metabolism, vol. 33, no. 2, pp. 411-423.e4 . https://doi.org/10.1016/j.cmet.2020.11.016
Cell Metabolism
Cell Metabolism
Summary Neutrophils can function and survive in injured and infected tissues, where oxygen and metabolic substrates are limited. Using radioactive flux assays and LC-MS tracing with U-13C glucose, glutamine, and pyruvate, we observe that neutrophils
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cad74cc910e5a97db33fae4b7012689
https://eprints.whiterose.ac.uk/169130/1/1-s2.0-S1550413120306513-main.pdf
https://eprints.whiterose.ac.uk/169130/1/1-s2.0-S1550413120306513-main.pdf
Autor:
Leila Reyes, Patrícia Coelho, Pranvera Sadiku, Tyler Morrison, Moira K. B. Whyte, Giulia Rinaldi, Simone Arienti, David H. Dockrell, Joseph A Willson, Sarah R. Walmsley
Publikováno v:
Blood
Willson, J A, Arienti, S, Sadiku, P, Reyes, L, Coelho, P, Morrison, T, Rinaldi, G, Dockrell, D H, Whyte, M K B & Walmsley, S R 2021, ' Neutrophil HIF-1α stabilisation is augmented by mitochondrial ROS produced via the glycerol 3-phosphate shuttle ', Blood . https://doi.org/10.1182/blood.2021011010
Willson, J A, Arienti, S, Sadiku, P, Reyes, L, Coelho, P, Morrison, T, Rinaldi, G, Dockrell, D H, Whyte, M K B & Walmsley, S R 2021, ' Neutrophil HIF-1α stabilisation is augmented by mitochondrial ROS produced via the glycerol 3-phosphate shuttle ', Blood . https://doi.org/10.1182/blood.2021011010
Neutrophils are predominantly glycolytic cells that derive little ATP from oxidative phosphorylation; however, they possess an extensive mitochondrial network and maintain a mitochondrial membrane potential. Although studies have shown neutrophils ne
Autor:
Joseph A Willson, Sarah R. Walmsley, Samuel P Williams, John S. Scotti, Ananda S. Mirchandani, Catherine J. Doherty, Rebecca S. Dickinson, Gail M. Preston, Moira K. B. Whyte, Fiona Murphy, Christopher J. Schofield
Publikováno v:
Dickinson, R S, Murphy, F, Doherty, C, Williams, S, Mirchandani, A, Willson, J A, Scotti, J S, Preston, G, Schofield, C J, Whyte, M K B & Walmsley, S R 2017, ' Pseudomonas expression of an oxygen sensing prolyl hydroxylase homologue regulates neutrophil host responses in vitro and in vivo ', Wellcome Open Research, vol. 2, pp. 104 . https://doi.org/10.12688/wellcomeopenres.12871.1
Wellcome Open Research
Wellcome Open Research
Background: Pseudomonas species are adapted to evade innate immune responses and can persist at sites of relative tissue hypoxia, including the mucus-plugged airways of patients with cystic fibrosis and bronchiectasis. The ability of these bacteria t
Autor:
Cormac T. Taylor, Bart Ghesquière, Massimilliano Mazzone, Helen M. Marriott, Veronica Moral, Patrick H. Maxwell, Eilise M. Ryan, Peter Carmeliet, Fiona Murphy, Joseph A Willson, David H. Dockrell, Amy Lewis, Rebecca S. Dickinson, Sarah R. Walmsley, Emily R. Watts, Martin Schneider, A. A. Roger Thompson, Pranvera Sadiku, Christopher W. Pugh, Ananda S. Mirchandani, Christopher J. Schofield, Peter J. Ratcliffe, Edwin R. Chilvers, Alison Harris, Moira K. B. Whyte, David Sammut
Publikováno v:
Sadiku, P, Willson, J A, Dickinson, R, Murphy, F, Harris, A, Lewis, A, Sammut, D, Mirchandani, A S, Ryan, E, Watts, E R, Thompson, A A R, Marriott, H M, Dockrell, D H, Taylor, C T, Schneider, M, Maxwell, P H, Chilvers, E R, Mazzone, M, Moral, V, Pugh, C W, Ratcliffe, P J, Schofield, C J, Ghesquiere, B, Carmeliet, P, Whyte, M K B & Walmsley, S R 2017, ' Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses ', Journal of Clinical Investigation, vol. 127, no. 9, pp. 3407-3420 . https://doi.org/10.1172/JCI90848
The Journal of Clinical Investigation
The Journal of Clinical Investigation
Fully activated innate immune cells are required for effective responses to infection, but their prompt deactivation and removal are essential for limiting tissue damage. Here, we have identified a critical role for the prolyl hydroxylase enzyme Phd2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba6dd30a163120cecfccb56afb32bb9
https://lirias.kuleuven.be/handle/123456789/668098
https://lirias.kuleuven.be/handle/123456789/668098
Autor:
Massimiliano Mazzone, Ananda S. Mirchandani, Simon J. Foster, David H. Dockrell, Peter Carmeliet, Emily R. Watts, Nadine Arnold, Joseph A Willson, Lynne Williams, Federico Taverna, Rebecca S. Dickinson, Pranvera Sadiku, Nicholas M. Morton, Catherine J. Doherty, A. A. Roger Thompson, Sarah R. Walmsley, Veronica Finisguerra, Edwin R. Chilvers, Amy Lewis, Shareen Forbes, Helen M. Marriott, Patricia Dos Santos Coelho, Randall S. Johnson, John P. Thomson, Moira K. B. Whyte, Julie A. Preston, Allan Lawrie, Fiona Murphy, Andrew S. Cowburn, Richard R. Meehan, Roland H Stimson, Jermaine Goveia, Abdul G. Hameed, Eilise M. Ryan, Adriana Tavares
Publikováno v:
Thompson, A A R, Dickinson, R S, Murphy, F, Thomson, J P, Marriott, H M, Tavares, A, Willson, J, Williams, L, Lewis, A, Mirchandani, A, Dos Santos Coelho, P, Doherty, C, Ryan, E, Watts, E, Morton, N M, Forbes, S, Stimson, R H, Hameed, A G, Arnold, N, Preston, J A, Lawrie, A, Finisguerra, V, Mazzone, M, Sadiku, P, Goveia, J, Taverna, F, Carmeliet, P, Foster, S J, Chilvers, E R, Cowburn, A S, Dockrell, D H, Johnson, R S, Meehan, R R, Whyte, M K B & Walmsley, S R 2017, ' Hypoxia determines survival outcomes of bacterial infection through HIF-1α–dependent reprogramming of leukocyte metabolism ', Science Immunology, vol. 2, no. 8, eaal2861 . https://doi.org/10.1126/sciimmunol.aal2861
Hypoxia and bacterial infection frequently coexist, in both acute and chronic clinical settings, and typically result in adverse clinical outcomes. To ameliorate this morbidity, we investigated the interaction between hypoxia and the host response. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b31b381051dc9e5a6366f78a268326
https://europepmc.org/articles/PMC5380213/
https://europepmc.org/articles/PMC5380213/
Autor:
Peter Carmeliet, David Sammut, Bart Ghesquière, Kate E. McDonald, Alison Harris, Moira K. B. Whyte, Fiona Murphy, Joseph A Willson, A. A. Roger Thompson, Sarah R. Walmsley, Tracie Plant, Pranvera Sadiku, John Newell-Price, Eleni Daniel, Amy Lewis, Robert C. Jones, Brian G. Keevil, Rebecca S. Dickinson
Publikováno v:
Jones, R, McDonald, K E, Willson, J A, Ghesquiere, B, Sammut, D, Daniel, E, Harris, A J, Lewis, A, Thompson, A A R, Dickinson, R S, Plant, T, Murphy, F, Sadiku, P, Keevil, B G, Carmeliet, P, Whyte, M K B, Newell-Price, J & Walmsley, S R 2016, ' Mutations in Succinate Dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1alpha expression ', Blood, vol. 127, no. 21, pp. 2641-2644 . https://doi.org/10.1182/blood-2016-02-696922
To the editor: Neutrophils are unusual in their reliance on glycolysis to maintain their energy requirements[1][1] despite the presence of mitochondria and tricarboxylic acid (TCA) cycle intermediaries.[2][2] This metabolic adaptation is thought in p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::880d4074482d889a79416bb79c747e8c
https://www.pure.ed.ac.uk/ws/files/28438823/2641.full.pdf
https://www.pure.ed.ac.uk/ws/files/28438823/2641.full.pdf
Autor:
Myriam Chimen, Simon Jones, Lynne R. Prince, Sarah R. Walmsley, Geoffrey Holmes, Sean R. Anderson, Stuart N. Farrow, Amy Sawtell, Roberto Solari, Mark Coles, Daniel Irimia, Stephen A. Renshaw, Visakan Kadirkamanathan, Aleksandra Bojarczuk, Anne L. Robertson, Bashar Hamza, Joseph A Willson, Catherine A. Loynes, Moira K. B. Whyte, Joseph Burgon, G. Ed Rainger
Diseases of failed inflammation resolution are common and largely incurable. Therapeutic induction of inflammation resolution is an attractive strategy to bring about healing without increasing susceptibility to infection. However, therapeutic target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a10e9f5a7e2acc25dadbdee4252cf8
https://eprints.whiterose.ac.uk/110823/1/nihms644781.pdf
https://eprints.whiterose.ac.uk/110823/1/nihms644781.pdf
Autor:
MK Whyte, V Finisguerra, Allan Lawrie, Massimilliano Mazzone, Randall S. Johnson, Julie A. Preston, Adriana Tavares, Aar Thompson, Simon J. Foster, Andrew S. Cowburn, Amy Lewis, Joseph A Willson, Richard R. Meehan, Lynne Williams, David H. Dockrell, Edwin R. Chilvers, Sarah R. Walmsley, Stuart J. Forbes, Abdul G. Hameed, Fiona Murphy, John P. Thomson, Helen M. Marriott, Roland H Stimson, Rebecca S. Dickinson
Publikováno v:
Thorax. 71:A61.2-A62
Introduction Systemic hypoxaemia and recurrent bacterial infections frequently co-exist in patients with acute and chronic lung disease and correlate with poor clinical outcomes. Inappropriate neutrophilic inflammation is regularly seen in these circ