Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Joseph A Nicolazzo"'
Autor:
Wei Wu, Joseph A Nicolazzo, Li Wen, Roger Chung, Roger Stankovic, Shisan S Bao, Chai K Lim, Bruce J Brew, Karen M Cullen, Gilles J Guillemin
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e59749 (2013)
To assess the role of the kynurenine pathway in the pathology of Alzheimer's disease (AD), the expression and localization of key components of the kynurenine pathway including the key regulatory enzyme tryptophan 2,3 dioxygenase (TDO), and the metab
Externí odkaz:
https://doaj.org/article/c69cbd3ce9a345eab273769269126948
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Fluids, solutes and immune cells have been demonstrated to drain from the brain and surrounding structures to the cervical lymph vessels and nodes in the neck via meningeal lymphatics, nasal lymphatics and/or lymphatic vessels associated
Externí odkaz:
https://doaj.org/article/5b5ca9f728804e528da472e67ea55e72
Autor:
Jae Pyun, HuiJing Koay, Pranav Runwal, Celeste Mawal, Ashley I. Bush, Yijun Pan, Paul S. Donnelly, Jennifer L. Short, Joseph A. Nicolazzo
Publikováno v:
Pharmaceutics, Vol 15, Iss 8, p 2084 (2023)
P-glycoprotein (P-gp), expressed at the blood-brain barrier (BBB), is critical in preventing brain access to substrate drugs and effluxing amyloid beta (Aβ), a contributor to Alzheimer’s disease (AD). Strategies to regulate P-gp expression therefo
Externí odkaz:
https://doaj.org/article/4dd3f90da69441b3b55e4e3bb31a06e6
Autor:
Yijun Pan, Yoshiteru Kagawa, Jiaqi Sun, Bradley J. Turner, Cheng Huang, Anup D. Shah, Ralf B. Schittenhelm, Joseph A. Nicolazzo
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2803 (2022)
For peripherally administered drugs to reach the central nervous system (CNS) and treat amyotrophic lateral sclerosis (ALS), they must cross the blood–brain barrier (BBB). As mounting evidence suggests that the ultrastructure of the BBB is altered
Externí odkaz:
https://doaj.org/article/ce792643f94e4e4a96edfc45439b2c0c
Publikováno v:
Molecular Pharmaceutics. 20:2686-2701
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddc79859649c223d70d7993e52443428
https://doi.org/10.1021/acs.molpharmaceut.3c00140
https://doi.org/10.1021/acs.molpharmaceut.3c00140
Publikováno v:
Pharmaceutical Research. 40:651-660
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1268bfd71d19ffdbe9e59475bd5d93b2
https://doi.org/10.1007/s11095-022-03458-w
https://doi.org/10.1007/s11095-022-03458-w
Autor:
Sanjeevini Babu Reddiar, Michael de Veer, Brett M. Paterson, Tara Sepehrizadeh, Dorothy C. C. Wai, Agota Csoti, Gyorgy Panyi, Joseph A. Nicolazzo, Raymond S. Norton
Publikováno v:
Molecular Pharmaceutics. 20:255-266
The voltage-gated potassium channel Kv1.3 regulates the pro-inflammatory function of microglia and is highly expressed in the post-mortem brains of individuals with Alzheimer's and Parkinson's diseases. HsTX1[R14A] is a selective and potent peptide i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b142453facdbba4417db68600f1fef6
https://doi.org/10.1021/acs.molpharmaceut.2c00614
https://doi.org/10.1021/acs.molpharmaceut.2c00614
A Fluorescent Peptide Toxin for Selective Visualization of the Voltage-Gated Potassium Channel KV1.3
Autor:
Dorothy C. C. Wai, Muhammad Umair Naseem, Gábor Mocsár, Sanjeevini Babu Reddiar, Yijun Pan, Agota Csoti, Peter Hajdu, Cameron Nowell, Joseph A. Nicolazzo, Gyorgy Panyi, Raymond S. Norton
Publikováno v:
Bioconjugate Chemistry. 33:2197-2212
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74356c1c18033396c070e24d36dcd079
https://doi.org/10.1021/acs.bioconjchem.2c00436
https://doi.org/10.1021/acs.bioconjchem.2c00436
Autor:
Daniel Malone, Kirsten Galbraith, Paul J. White, Betty Exintaris, Joseph A. Nicolazzo, Tina Brock, Andreia Bruno-Tomé, Jennifer L. Short, Ian Larson
Publikováno v:
Pharmacy, Vol 9, Iss 4, p 156 (2021)
Whilst curriculum revision is commonplace, whole degree transformation is less so. In this paper we discuss the rationale, design and implementation of a unique pharmacy program by a research-intensive faculty. The new Monash pharmacy curriculum, whi
Externí odkaz:
https://doaj.org/article/029e679ad5f943ad8bea80aa41163841
Autor:
Yijun Pan, Yoshiteru Kagawa, Jiaqi Sun, Deanna S. Deveson Lucas, Ryusuke Takechi, John C. L. Mamo, Dorothy C. C. Wai, Raymond S. Norton, Liang Jin, Joseph A. Nicolazzo
Publikováno v:
Neurotherapeutics.
Increased expression of the voltage-gated potassium channel Kv1.3 in activated microglia, and the subsequent release of pro-inflammatory mediators, are closely associated with the progression of Alzheimer’s disease (AD). Studies have shown that red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33a8f7c05ce7684feb92012047e5812f
https://doi.org/10.1007/s13311-023-01387-z
https://doi.org/10.1007/s13311-023-01387-z