Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Joseph A Mindell"'
Publikováno v:
eLife, Vol 12 (2024)
The neurotransmitter:sodium symporters (NSSs) are secondary active transporters that couple the reuptake of substrate to the symport of one or two sodium ions. One bound Na+ (Na1) contributes to the substrate binding, while the other Na+ (Na2) is tho
Externí odkaz:
https://doaj.org/article/b541b07cee2b4b2bb93fdbec258eadb3
Autor:
Xavier Leray, Jacob K Hilton, Kamsi Nwangwu, Alissa Becerril, Vedrana Mikusevic, Gabriel Fitzgerald, Anowarul Amin, Mary R Weston, Joseph A Mindell
Publikováno v:
eLife, Vol 11 (2022)
The acidic luminal pH of lysosomes, maintained within a narrow range, is essential for proper degrative function of the organelle and is generated by the action of a V-type H+ ATPase, but other pathways for ion movement are required to dissipate the
Externí odkaz:
https://doaj.org/article/ba99f83a0c944e9299218d4891a98871
Publikováno v:
eLife, Vol 6 (2017)
The number of ions required to drive substrate transport through a secondary active transporter determines the protein’s ability to create a substrate gradient, a feature essential to its physiological function, and places fundamental constraints o
Externí odkaz:
https://doaj.org/article/2c95ae11f56641b4938aab27982b7df7
Publikováno v:
eLife, Vol 3 (2014)
Peptide transport plays an important role in cellular homeostasis as a key route for nitrogen acquisition in mammalian cells. PepT1 and PepT2, the mammalian proton coupled peptide transporters (POTs), function to assimilate and retain diet-derived pe
Externí odkaz:
https://doaj.org/article/1321c0366ba44fd79ee75583eb5b047b
The neurotransmitter:sodium symporters (NSSs) are secondary active transporters that couple the reuptake of substrate to the symport of one or two sodium ions. One bound Na+(Na1) contributes to the substrate binding, while the other Na+(Na2) is thoug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ab728592e8f419f710cc2826819185c
https://doi.org/10.1101/2023.04.04.535525
https://doi.org/10.1101/2023.04.04.535525
Autor:
Jacob K Hilton, Xavier Leray, Kamsi Nwangwu, Alissa Becerril, Vedrana Mikusevic, Gabriel Fitzgerald, Anowarul Amin, Mary R Weston, Joseph A Mindell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80647cf15828fb6fb8ac6eb976d6a4d9
https://doi.org/10.7554/elife.74136.sa2
https://doi.org/10.7554/elife.74136.sa2
Autor:
William J. Rice, Joseph A. Mindell, Jacob K. Hilton, David B. Sauer, Jinmei Song, Nathan K. Karpowich, Bing Wang, Da-Neng Wang
Publikováno v:
Nature
Citrate is best known as an intermediate in the tricarboxylic acid cycle of the cell. In addition to this essential role in energy metabolism, the tricarboxylate anion also acts as both a precursor and a regulator of fatty acid synthesis1-3. Thus, th
Autor:
Jacob K. Hilton, Joseph A. Mindell
Publikováno v:
Biophysical Journal. 122:397a
Publikováno v:
Biophysical Journal. 122:397a
Publikováno v:
The Journal of Biological Chemistry
The divalent anion sodium symporter (DASS) family (SLC13) plays critical roles in metabolic homeostasis, influencing many processes, including fatty acid synthesis, insulin resistance, and adiposity. DASS transporters catalyze the Na+-driven concentr