Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Joseph A Mindell"'
Publikováno v:
eLife, Vol 12 (2024)
The neurotransmitter:sodium symporters (NSSs) are secondary active transporters that couple the reuptake of substrate to the symport of one or two sodium ions. One bound Na+ (Na1) contributes to the substrate binding, while the other Na+ (Na2) is tho
Externí odkaz:
https://doaj.org/article/b541b07cee2b4b2bb93fdbec258eadb3
Autor:
Xavier Leray, Jacob K Hilton, Kamsi Nwangwu, Alissa Becerril, Vedrana Mikusevic, Gabriel Fitzgerald, Anowarul Amin, Mary R Weston, Joseph A Mindell
Publikováno v:
eLife, Vol 11 (2022)
The acidic luminal pH of lysosomes, maintained within a narrow range, is essential for proper degrative function of the organelle and is generated by the action of a V-type H+ ATPase, but other pathways for ion movement are required to dissipate the
Externí odkaz:
https://doaj.org/article/ba99f83a0c944e9299218d4891a98871
Autor:
Apeksha Singh, Frank V Marcoline, Salome Veshaguri, Aimee W Kao, Marcel Bruchez, Joseph A Mindell, Dimitrios Stamou, Michael Grabe
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 12, p e1007539 (2019)
The lumenal pH of an organelle is one of its defining characteristics and central to its biological function. Experiments have elucidated many of the key pH regulatory elements and how they vary from compartment-to-compartment, and continuum mathemat
Externí odkaz:
https://doaj.org/article/01d7c71e8534490fad934f619561704f
The neurotransmitter:sodium symporters (NSSs) are secondary active transporters that couple the reuptake of substrate to the symport of one or two sodium ions. One bound Na+(Na1) contributes to the substrate binding, while the other Na+(Na2) is thoug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ab728592e8f419f710cc2826819185c
https://doi.org/10.1101/2023.04.04.535525
https://doi.org/10.1101/2023.04.04.535525
Publikováno v:
eLife, Vol 6 (2017)
The number of ions required to drive substrate transport through a secondary active transporter determines the protein’s ability to create a substrate gradient, a feature essential to its physiological function, and places fundamental constraints o
Externí odkaz:
https://doaj.org/article/2c95ae11f56641b4938aab27982b7df7
Autor:
William J. Rice, Joseph A. Mindell, Jacob K. Hilton, David B. Sauer, Jinmei Song, Nathan K. Karpowich, Bing Wang, Da-Neng Wang
Publikováno v:
Nature
Citrate is best known as an intermediate in the tricarboxylic acid cycle of the cell. In addition to this essential role in energy metabolism, the tricarboxylate anion also acts as both a precursor and a regulator of fatty acid synthesis1-3. Thus, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c94d427bab3df3b9ca64667d24199fdc
https://doi.org/10.1038/s41586-021-03230-x
https://doi.org/10.1038/s41586-021-03230-x
Publikováno v:
The Journal of Biological Chemistry
The divalent anion sodium symporter (DASS) family (SLC13) plays critical roles in metabolic homeostasis, influencing many processes, including fatty acid synthesis, insulin resistance, and adiposity. DASS transporters catalyze the Na+-driven concentr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfa49ce44ea9743d1ca8284864657eac
https://doi.org/10.1074/jbc.ra120.013894
https://doi.org/10.1074/jbc.ra120.013894
Autor:
Jacob K Hilton, Xavier Leray, Kamsi Nwangwu, Alissa Becerril, Vedrana Mikusevic, Gabriel Fitzgerald, Anowarul Amin, Mary R Weston, Joseph A Mindell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80647cf15828fb6fb8ac6eb976d6a4d9
https://doi.org/10.7554/elife.74136.sa2
https://doi.org/10.7554/elife.74136.sa2
Autor:
Carolina Montano, Thomas Cassini, Shira G. Ziegler, Manfred Boehm, Elena‐Raluca Nicoli, Joseph A. Mindell, Ariane G. Soldatos, Irini Manoli, Lynne Wolfe, Ellen F. Macnamara, May Christine V. Malicdan, David R. Adams, Cynthia J. Tifft, Camilo Toro, William A. Gahl
Publikováno v:
Journal of inherited metabolic diseaseREFERENCES. 45(5)
Living with an undiagnosed medical condition places a tremendous burden on patients, their families, and their healthcare providers. The Undiagnosed Diseases Program (UDP) was established at the National Institutes of Health (NIH) in 2008 with the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0dc8841b047aa3816d197bdef9f9660
https://pubmed.ncbi.nlm.nih.gov/35490291
https://pubmed.ncbi.nlm.nih.gov/35490291
Autor:
Jacob K. Hilton, Joseph A. Mindell
Publikováno v:
Biophysical Journal. 122:397a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::347c7b922f0460d2ca5e224cac51cbfc
https://doi.org/10.1016/j.bpj.2022.11.2167
https://doi.org/10.1016/j.bpj.2022.11.2167