Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Joseph A McQuail"'
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52728 (2012)
Radiation therapy has proven efficacy for treating brain tumors and metastases. Higher doses and larger treatment fields increase the probability of eliminating neoplasms and preventing reoccurrence, but dose and field are limited by damage to normal
Externí odkaz:
https://doaj.org/article/bff66d27e1c04b438741192f4e34e187
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2024)
The glucocorticoid (GC) hypothesis posits that effects of stress and dysregulated hypothalamic-pituitary-adrenal axis activity accumulate over the lifespan and contribute to impairment of neural function and cognition in advanced aging. The validity
Externí odkaz:
https://doaj.org/article/76ddd7d6ed274c9499e2d45771514323
Autor:
Paul W. Braunstein, David J. Horovitz, Andreina M. Hampton, Fiona Hollis, Lori A. Newman, Reilly T. Enos, Joseph A. McQuail
Publikováno v:
Aging Brain, Vol 5, Iss , Pp 100116- (2024)
Defective brain glucose utilization is a hallmark of Alzheimer’s disease (AD) while Type II diabetes and elevated blood glucose escalate the risk for AD in later life. Isolating contributions of normal aging from coincident metabolic or brain disea
Externí odkaz:
https://doaj.org/article/c92a317560a148b6bad5858a6017facd
Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies
Autor:
Joseph A. McQuail, Amy R. Dunn, Yaakov Stern, Carol A. Barnes, Gerd Kempermann, Peter R. Rapp, Catherine C. Kaczorowski, Thomas C. Foster
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2021)
The goal of this review article is to provide a resource for longitudinal studies, using animal models, directed at understanding and modifying the relationship between cognition and brain structure and function throughout life. We propose that forth
Externí odkaz:
https://doaj.org/article/36f44c766a3f4b158589d4ac6f731c19
Autor:
Caesar M. Hernandez, Joseph A. McQuail, Tyler W. Ten Eyck, Alexa-Rae Wheeler, Chase C. Labiste, Barry Setlow, Jennifer L. Bizon
Publikováno v:
Neuropharmacology
The ability to decide adaptively between immediate vs. delayed gratification (intertemporal choice) is critical for well-being and is associated with a range of factors that influence quality of life. In contrast to young adults, many older adults sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d6473fc39940b2ba8124e20bd4055b
https://europepmc.org/articles/PMC9297337/
https://europepmc.org/articles/PMC9297337/
Autor:
Anthony C. Johnson, Patricia Izbicki, Nancy Padilla-Coreano, Joseph A. McQuail, Bianca J. Marlin, Elizabeth J. Glover, Mychael V. Lourenco, Alexandra Colón-Rodriquez, Naomi E. Charalambakis, Ignacio Obeso, Cara M. Altimus, Ryan A Makinson, Michael F. Wells
Publikováno v:
J Neurosci
On the 50th anniversary of the Society for Neuroscience, we reflect on the remarkable progress that the field has made in understanding the nervous system, and look forward to the contributions of the next 50 years. We predict a substantial accelerat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c3387e6dfad837d32b2481328edf683
https://europepmc.org/articles/PMC6939479/
https://europepmc.org/articles/PMC6939479/
Publikováno v:
Neurobiology of Aging. 71:156-160
A substantial literature details the relationship between age-related changes to the hypothalamic-pituitary-adrenal axis and deterioration of mnemonic functions that depend on the hippocampus. The relationship between adrenocortical status and other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49821df61336d7107757d4a693bf759b
https://doi.org/10.1016/j.neurobiolaging.2018.07.015
https://doi.org/10.1016/j.neurobiolaging.2018.07.015
Autor:
Charles J. Frazier, Caesar M Hernandez, B. Sofia Beas, Kyle B. Kelly, Jennifer L. Bizon, Joseph A. McQuail
Publikováno v:
Neuropharmacology
Ionotropic glutamate receptors of the NMDA and AMPA subtypes transduce excitatory signaling on neurons in the prefrontal cortex (PFC) in support of cognitive flexibility. Cognitive flexibility is reliably observed to decline at advanced ages, coincid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4ba7b619356131bcb33ff0e9058d006
https://doi.org/10.1016/j.neuropharm.2021.108720
https://doi.org/10.1016/j.neuropharm.2021.108720
Publikováno v:
Neuroscience. 345:274-286
The prefrontal cortex (PFC) is critical for the ability to flexibly adapt established patterns of behavior in response to a change in environmental contingencies. Impaired behavioral flexibility results in maladaptive strategies such as perseveration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910ef4362f20ab00e6ae9f733655914f
https://doi.org/10.1016/j.neuroscience.2016.02.014
https://doi.org/10.1016/j.neuroscience.2016.02.014
Autor:
Abbi R. Hernandez, Caesar M. Hernandez, Leah M. Truckenbrod, Keila T. Campos, Joseph A. McQuail, Jennifer L. Bizon, Sara N. Burke
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience
As the number of individuals living beyond the age of 65 is rapidly increasing, so is the need to develop strategies to combat the age-related cognitive decline that may threaten independent living. Although the link between altered neuronal signalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a52d56bb1ec3592507219d0d1cef438
https://doi.org/10.3389/fnagi.2019.00239
https://doi.org/10.3389/fnagi.2019.00239