Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Joseph A Didonato"'
Autor:
Niladri S Kar, Daniel Ferguson, Nianli Zhang, Erik I Waldorff, James T Ryaby, Joseph A DiDonato
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0247659 (2021)
Pulsed-electromagnetic-field (PEMF) treatment was found to enhance cellular differentiation of the mouse preosteoblast, MC3T3-E1, to a more osteoblastic phenotype. Differentiation genes such as Alp, BSPI, cFos, Ibsp, Osteocalcin, Pthr1 and Runx2 show
Externí odkaz:
https://doaj.org/article/77741fbe0f81478c94b5f9342edf870e
Autor:
Prasenjit Prasad Saha, Valentin Gogonea, Wendy Sweet, Maradumane L. Mohan, Khuraijam Dhanachandra Singh, James T. Anderson, Deepthi Mallela, Conner Witherow, Niladri Kar, Kate Stenson, Terri Harford, Michael A. Fischbach, J. Mark Brown, Sadashiva S. Karnik, Christine S. Moravec, Joseph A. DiDonato, Sathyamangla Venkata Naga Prasad, Stanley L. Hazen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Allosteric modulation is a central mechanism for metabolic regulation but has yet to be described for a gut microbiota-host interaction. Phenylacetylglutamine (PAGln), a gut microbiota-derived metabolite, has previously been clinically assoc
Externí odkaz:
https://doaj.org/article/135a6fb0bc4149b78a90558a91ecc051
Autor:
Asif J Iqbal, Tessa J Barrett, Lewis Taylor, Eileen McNeill, Arun Manmadhan, Carlota Recio, Alfredo Carmineri, Maximillian H Brodermann, Gemma E White, Dianne Cooper, Joseph A DiDonato, Maryam Zamanian-Daryoush, Stanley L Hazen, Keith M Channon, David R Greaves, Edward A Fisher
Publikováno v:
eLife, Vol 5 (2016)
Apolipoprotein A1 (apoA1) is the major protein component of high-density lipoprotein (HDL) and has well documented anti-inflammatory properties. To better understand the cellular and molecular basis of the anti-inflammatory actions of apoA1, we explo
Externí odkaz:
https://doaj.org/article/4f6ab8947a3d4308a252fadfcd67c3a6
Autor:
Joseph A Bauer, Joseph A Lupica, Heidi Schmidt, Bei H Morrison, Rebecca M Haney, Rhonda K Masci, Rebecca M Lee, Joseph A Didonato, Daniel J Lindner
Publikováno v:
PLoS ONE, Vol 2, Iss 12, p e1313 (2007)
Nitrosylcobalamin (NO-Cbl) is a chemotherapeutic pro-drug derived from vitamin B12 that preferentially delivers nitric oxide (NO) to tumor cells, based upon increased receptor expression. NO-Cbl induces Apo2L/TRAIL-mediated apoptosis and inhibits sur
Externí odkaz:
https://doaj.org/article/cb9a3846182e4721a2012c84d91d423b
Autor:
Mohammed Dwidar, Jennifer A. Buffa, Zeneng Wang, Akeem Santos, Aaron N. Tittle, Xiaoming Fu, Adeline M. Hajjar, Joseph A. DiDonato, Stanley L. Hazen
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Trimethylamine-N-oxide (TMAO) is a major pro-atherogenic and pro-thrombotic metaorganismal molecule produced through the initial conversion of the dietary L-carnitine and other precursors into trimethylamine (TMA). We recently identified a d
Externí odkaz:
https://doaj.org/article/7362f04bfb034f04bc4b0a9a6cc2d00a
Autor:
Meng Wang, Xinmin S Li, Zeneng Wang, Marcia C de Oliveira Otto, Rozenn N Lemaitre, Amanda Fretts, Nona Sotoodehnia, Matthew Budoff, Ina Nemet, Joseph A DiDonato, Wai Hong Wilson Tang, Bruce M Psaty, David S Siscovick, Stanley L Hazen, Dariush Mozaffarian
Publikováno v:
European Heart Journal. 44:1608-1618
Aims Little is known about associations of trimethylamine N-oxide (TMAO), a novel gut microbiota-generated metabolite of dietary phosphatidylcholine and carnitine, and its changes over time with all-cause and cause-specific mortality in the general p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::823b39140f1107c9440b763214aff348
https://doi.org/10.1093/eurheartj/ehad089
https://doi.org/10.1093/eurheartj/ehad089
Autor:
Kymberleigh A. Romano, Ina Nemet, Prasenjit Prasad Saha, Arash Haghikia, Xinmin S. Li, Maradumane L. Mohan, Beth Lovano, Laurie Castel, Marco Witkowski, Jennifer A. Buffa, Yu Sun, Lin Li, Christopher M. Menge, Ilja Demuth, Maximilian König, Elisabeth Steinhagen-Thiessen, Joseph A. DiDonato, Arjun Deb, Fredrik Bäckhed, W.H. Wilson Tang, Sathyamangla Venkata Naga Prasad, Ulf Landmesser, David R. Van Wagoner, Stanley L. Hazen
Publikováno v:
Circulation: Heart Failure. 16
Background: The gut microbiota-dependent metabolite phenylacetylgutamine (PAGln) is both associated with atherothrombotic heart disease in humans, and mechanistically linked to cardiovascular disease pathogenesis in animal models via modulation of ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c74981c07edceb9866d05ff4c935a9
https://doi.org/10.1161/circheartfailure.122.009972
https://doi.org/10.1161/circheartfailure.122.009972
Autor:
Meng Wang, Zeneng Wang, Yujin Lee, Heidi T.M. Lai, Marcia C. de Oliveira Otto, Rozenn N. Lemaitre, Amanda Fretts, Nona Sotoodehnia, Matthew Budoff, Joseph A. DiDonato, Barbara McKnight, W.H. Wilson Tang, Bruce M. Psaty, David S. Siscovick, Stanley L. Hazen, Dariush Mozaffarian
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42
Background:Effects of animal source foods (ASF) on atherosclerotic cardiovascular disease (ASCVD) and underlying mechanisms remain controversial. We investigated prospective associations of different ASF with incident ASCVD and potential mediation by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e4f8ddb54f657080d7de69aa56e88c
https://doi.org/10.1161/atvbaha.121.316533
https://doi.org/10.1161/atvbaha.121.316533
Autor:
Ghaleb Khirfan, Raed A. Dweik, Joseph A. DiDonato, Manshi Li, Xiaofeng Wang, Gustavo A. Heresi
Publikováno v:
Pulmonary Circulation, Vol 11 (2021)
Recent studies have shown low high-density lipoprotein cholesterol (HDL-C) and dysregulated lipid metabolism in chronic thromboembolic pulmonary hypertension (CTEPH). Apolipoprotein A-I (ApoA-I) is the major protein component of HDL-C and mediates mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e10c4fbda5b1a70991d26cf9cf5d0b8f
https://doi.org/10.1177/20458940211010371
https://doi.org/10.1177/20458940211010371
Publikováno v:
Anticancer Research. 40:6751-6763
Background/aim Chemoresistance is a major consequence of multicycle chemotherapy and can be attributed to constitutive activation of pro-survival signaling pathways. Nitric oxide is a ubiquitous signaling molecule which has been shown to inhibit seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e74ccf775bb106387d46d7cfbf0e7f57
https://doi.org/10.21873/anticanres.14698
https://doi.org/10.21873/anticanres.14698