Zobrazeno 1 - 10
of 425
pro vyhledávání: '"Joseph A Trapani"'
Autor:
Anna-Marie Pedde, Hyunu Kim, Sainitin Donakonda, Tobias Baumann, Felix Bayerl, Philippa Meiser, Anna Hirschberger, Christine Klement, Simon Grassmann, Rupert Öllinger, Norbert Hüser, Daniel Hartmann, Melanie Laschinger, Joseph A. Trapani, Alfred Zippelius, Tobias Bald, Gabriela M. Wiedemann, Roland Rad, Joseph C. Sun, Bastian Höchst, Jan P. Böttcher
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114855- (2024)
Summary: Natural killer (NK) cells are critical for anti-metastatic immunity and can eliminate metastasizing tumor cells within circulation and sites of metastatic seeding. Here, we show that disseminated tumor cells (DTCs) colonizing the mouse lung
Externí odkaz:
https://doaj.org/article/f59733942ee14e7693060de6e6edd91a
Autor:
Thu Nguyen, Minyu Wang, Sean Macdonald, David Goode, Sevastjan Kranz, Paul Joseph Neeson, Kevin Thia, Joseph A Trapani, Lei Qin, Simone Belobrov, David Wiesenfeld
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 10 (2024)
Background Locally advanced oral cavity squamous cell carcinoma (OCSCC) presents a significant clinical challenge despite being partially responsive to standard treatment modalities. This study investigates the prognostic implications of programmed d
Externí odkaz:
https://doaj.org/article/69d242b0d40649e886d2d1e2ec752ee8
Autor:
Vivien R. Sutton, Sally V. Watt, Hedieh Akhlaghi, David C. Cipolla, Kuan-Ju Chen, Daniel LaSala, Patrick P. McDonald, Paul A. Beavis, Isabelle Munoz, Adrian W. Hodel, Tahereh Noori, Ilia Voskoboinik, Joseph A. Trapani
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Recently developed small-molecule inhibitors of the lysosomal protease dipeptidyl peptidase 1 (DPP1), also known as cathepsin C (CatC), can suppress suppurative inflammation in vivo by blocking the processing of zymogenic (pro-) forms of neutrophil s
Externí odkaz:
https://doaj.org/article/637ceae3f9ef4a27add5a0ac7f8e1bc1
Autor:
Chelsea Mayoh, Andrew J. Gifford, Rachael Terry, Loretta M. S. Lau, Marie Wong, Padmashree Rao, Tyler Shai-Hee, Federica Saletta, Dong-Anh Khuong-Quang, Vicky Qin, Marion K. Mateos, Deborah Meyran, Katherine E. Miller, Aysen Yuksel, Emily V. A. Mould, Rachel Bowen-James, Dinisha Govender, Akanksha Senapati, Nataliya Zhukova, Natacha Omer, Hetal Dholaria, Frank Alvaro, Heather Tapp, Yonatan Diamond, Luciano Dalla Pozza, Andrew S. Moore, Wayne Nicholls, Nicholas G. Gottardo, Geoffrey McCowage, Jordan R. Hansford, Seong-Lin Khaw, Paul J. Wood, Daniel Catchpoole, Catherine E. Cottrell, Elaine R. Mardis, Glenn M. Marshall, Vanessa Tyrrell, Michelle Haber, David S. Ziegler, Orazio Vittorio, Joseph A. Trapani, Mark J. Cowley, Paul J. Neeson, Paul G. Ekert
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-18 (2023)
Abstract Background Molecular profiling of the tumour immune microenvironment (TIME) has enabled the rational choice of immunotherapies in some adult cancers. In contrast, the TIME of paediatric cancers is relatively unexplored. We speculated that a
Externí odkaz:
https://doaj.org/article/fbd7979e6f4b4aebb70a711623639d1f
Autor:
Fiona Hegi-Johnson, Stacey Rudd, Rodney J. Hicks, Dirk De Ruysscher, Joseph A. Trapani, Thomas John, Paul Donnelly, Benjamin Blyth, Gerard Hanna, Sarah Everitt, Peter Roselt, Michael P. MacManus
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-15 (2022)
Abstract Immune checkpoint inhibitors and related molecules can achieve tumour regression, and even prolonged survival, for a subset of cancer patients with an otherwise dire prognosis. However, it remains unclear why some patients respond to immunot
Externí odkaz:
https://doaj.org/article/5d38189bd1004ec4a08c3e6cbbdf9ecf
Autor:
Mohamed Fareh, Wei Zhao, Wenxin Hu, Joshua M. L. Casan, Amit Kumar, Jori Symons, Jennifer M. Zerbato, Danielle Fong, Ilia Voskoboinik, Paul G. Ekert, Rajeev Rudraraju, Damian F. J. Purcell, Sharon R. Lewin, Joseph A. Trapani
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Cas13b can be harnessed to target and degrade RNA transcripts inside a cellular environment. Here the authors reprogram Cas13b to target SARSCoV-2 transcripts in infected mammalian cells and reveal its resilience to variants thanks to single mismatch
Externí odkaz:
https://doaj.org/article/c9a22d0a72d14aecb6991c4771cee7a6
Autor:
Mayura V. Wagle, Stephin J. Vervoort, Madison J. Kelly, Willem Van Der Byl, Timothy J. Peters, Ben P. Martin, Luciano G. Martelotto, Simone Nüssing, Kelly M. Ramsbottom, James R. Torpy, Deborah Knight, Sinead Reading, Kevin Thia, Lisa A. Miosge, Debbie R. Howard, Renee Gloury, Sarah S. Gabriel, Daniel T. Utzschneider, Jane Oliaro, Jonathan D. Powell, Fabio Luciani, Joseph A. Trapani, Ricky W. Johnstone, Axel Kallies, Christopher C. Goodnow, Ian A. Parish
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Exhausted T cells arise when chronic activation triggers functional defects. Here the authors show that chronic antigenic stimulation in both tumour and infection models induces the expression of EGR2, which drives and stabilises exhausted cell epige
Externí odkaz:
https://doaj.org/article/835402bfc1a5448994d0c742c77cfabd
Autor:
Kelden Richardson, Simon P. Keam, Joe Jiang Zhu, Deborah Meyran, Criselle D’Souza, Sean Macdonald, Kerry Campbell, Michael Robbins, Natalie A. Bezman, Kirsten Todd, Hang Quach, David S. Ritchie, Simon J. Harrison, H. Miles Prince, Joseph A. Trapani, Misty R. Jenkins, Paul A. Beavis, Phillip K. Darcy, Paul J. Neeson
Publikováno v:
Haematologica, Vol 108, Iss 1 (2022)
Patients with refractory relapsed multiple myeloma respond to combination treatment with elotuzumab and lenalidomide. The mechanisms underlying this observation are not fully understood. Furthermore, biomarkers predictive of response have not been id
Externí odkaz:
https://doaj.org/article/330bde42af204d128415d365b42720c4
Autor:
Shahneen Sandhu, David E Gyorki, Richard A Scolyer, George Au-Yeung, Grant A McArthur, Minyu Wang, Georgina Long, Angela Pizzolla, Paul Joseph Neeson, Soroor Zadeh, Kevin Thia, James S Wilmott, Miles C Andrews, Ali Weppler, Joseph A Trapani, Melissa J Davis
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 4 (2022)
Externí odkaz:
https://doaj.org/article/a361f758191942e486d27c60762fc49d
Autor:
David D Feehan, Khusraw Jamil, Maria J Polyak, Henry Ogbomo, Mark Hasell, Shu Shun Li, Richard F Xiang, Michael Parkins, Joseph A Trapani, Joe J Harrison, Christopher H Mody
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1010325 (2022)
Pseudomonas aeruginosa is an opportunistic pathogen that often infects individuals with the genetic disease cystic fibrosis, and contributes to airway blockage and loss of lung function. Natural killer (NK) cells are cytotoxic, granular lymphocytes t
Externí odkaz:
https://doaj.org/article/b778c7014af347808053473fb513adcf