Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Joseph A, Brzezinski"'
Autor:
Bernadett Bosze, Julissa Suarez-Navarro, Illiana Cajias, Joseph A Brzezinski Iv, Nadean L Brown
Publikováno v:
PLoS Genetics, Vol 19, Iss 9, p e1010928 (2023)
In the vertebrate eye, Notch ligands, receptors, and ternary complex components determine the destiny of retinal progenitor cells in part by regulating Hes effector gene activity. There are multiple paralogues for nearly every node in this pathway, w
Externí odkaz:
https://doaj.org/article/095e2d306d4a4925b36f54821636f3a5
Publikováno v:
Journal of Academic Ophthalmology, Vol 11, Iss 01, Pp e30-e35 (2019)
Abstract Objective To allow medical undergraduate students an exposure to ophthalmology in the preclinical years as well as introduce concepts of basic and clinical science in ophthalmology for medical students. Methods The 10-session elective wa
Externí odkaz:
https://doaj.org/article/e3852826e4ae4c6fad4a31f9cdd7ecb9
Autor:
Silvia Aparicio-Domingo, Miguel Flores-Bellver, Hannah Cobb, Kang V. Li, Bogi Conrad, Conan Chen, Joseph A. Brzezinski, M. Valeria Canto-Soler
Publikováno v:
Neuromethods ISBN: 9781071627198
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e3aa4599cdd3c639ec1b90bd169f17b
https://doi.org/10.1007/978-1-0716-2720-4_6
https://doi.org/10.1007/978-1-0716-2720-4_6
Autor:
Taylor S Mills, Tatiana Eliseeva, Stephanie M Bersie, Grace Randazzo, Jhenya Nahreini, Ko Uoon Park, Joseph A Brzezinski
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0176905 (2017)
The mouse retina comprises seven major cell types that exist in differing proportions. They are generated from multipotent progenitors in a stochastic manner, such that the relative frequency of any given type generated changes over time. The mechani
Externí odkaz:
https://doaj.org/article/2d62ab9324ca4622a34e3484f4a7d17d
Autor:
Andrew J. O. Smith, Ram H. Nagaraj, Ko Uoon Park, I. Michael Wormstone, Mina B. Pantcheva, Mi-Hyun Nam, Joseph A. Brzezinski, James J. Galligan, Kristofer S. Fritz
Publikováno v:
Biochem J
Posterior capsule opacification (PCO) is a complication after cataract surgery that can disrupt vision. The epithelial to mesenchymal transition (EMT) of lens epithelial cells (LECs) in response to transforming growth factor β2 (TGFβ2) has been con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef21cdf64e773c25e1099bbe33c34d6c
https://doi.org/10.1042/bcj20190540
https://doi.org/10.1042/bcj20190540
Autor:
Michael L. Kaufman, Noah B. Goodson, Emma Office, Michael Schwanke, Ko Uoon Park, Joseph A. Brzezinski, Austin Hensley, Kenneth Jones, Joy Abraham, Sophia R Schneider
Publikováno v:
Development
During retinal development, a large subset of progenitors upregulates the transcription factor Otx2, which is required for photoreceptor and bipolar cell formation. How these retinal progenitor cells initially activate Otx2 expression is unclear. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bda4118184cd26f098d3c0e5f081c93
https://doi.org/10.1242/dev.199399
https://doi.org/10.1242/dev.199399
Publikováno v:
Journal of Academic Ophthalmology, Vol 11, Iss 01, Pp e30-e35 (2019)
Objective To allow medical undergraduate students an exposure to ophthalmology in the preclinical years as well as introduce concepts of basic and clinical science in ophthalmology for medical students. Methods The 10-session elective was offered to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf256b673278e580edc541b1941f355
https://doi.org/10.1055/s-0039-1688761
https://doi.org/10.1055/s-0039-1688761
Autor:
Noah B. Goodson, Jason S. Silver, Joseph A. Brzezinski, Ko U. Park, William W. Hauswirth, Vince A. Chiodo
Publikováno v:
Dev Biol
The transcription factors Prdm1 (Blimp1) and Vsx2 (Chx10) work downstream of Otx2 to regulate photoreceptor and bipolar cell fates in the developing retina. Mice that lack Vsx2 fail to form bipolar cells while Prdm1 mutants form excess bipolars at th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb5cf52c4798a5e1e4fc97211dfbcdf
https://europepmc.org/articles/PMC7386070/
https://europepmc.org/articles/PMC7386070/
Publikováno v:
Development (Cambridge, England). 147(13)
The transcription factor OTX2 is required for photoreceptor and bipolar cell formation in the retina. It directly activates the transcription factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c0b421e70e3e3ab06060e7ce83146cdd
https://pubmed.ncbi.nlm.nih.gov/32541005
https://pubmed.ncbi.nlm.nih.gov/32541005
Publikováno v:
Development.
The transcription factor Otx2 is required for photoreceptor and bipolar cell formation in the retina. It directly activates the transcription factors Prdm1 and Vsx2 through cell type-specific enhancers. Prdm1 and Vsx2 work in opposition, such that Pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31017e5e68f464ba5763a584bcee68c2
https://doi.org/10.1242/dev.190272
https://doi.org/10.1242/dev.190272