Zobrazeno 1 - 10
of 192
pro vyhledávání: '"Joseph A, Baur"'
Autor:
Angela Song, Nicole Zhao, Diana C. Hilpert, Caroline Perry, Joseph A. Baur, Douglas C. Wallace, Patrick M. Schaefer
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract NADH autofluorescence imaging is a promising approach for visualizing energy metabolism at the single-cell level. However, it is sensitive to the redox ratio and the total NAD(H) amount, which can change independently from each other, for ex
Externí odkaz:
https://doaj.org/article/5e7d561d5fc34f3bb69be553add48eb6
Autor:
Elizabeth Nunn, Natasha Jaiswal, Matthew Gavin, Kahealani Uehara, Megan Stefkovich, Karima Drareni, Ryan Calhoun, Michelle Lee, Corey D. Holman, Joseph A. Baur, Patrick Seale, Paul M. Titchenell
Publikováno v:
Molecular Metabolism, Vol 80, Iss , Pp 101880- (2024)
Objective: Glucagon-like peptide 1 (GLP-1) receptor agonists reduce food intake, producing remarkable weight loss in overweight and obese individuals. While much of this weight loss is fat mass, there is also a loss of lean mass, similar to other app
Externí odkaz:
https://doaj.org/article/3c25c8696bac45cc8a33929b89a5909f
Publikováno v:
Antioxidants, Vol 13, Iss 5, p 546 (2024)
Emerging data indicate that lung macrophages (LM) may provide a novel biomarker to classify disease endotypes in bronchopulmonary dysplasia (BPD), a form of infant chronic lung disease, and that augmentation of the LM phenotype may be a potential the
Externí odkaz:
https://doaj.org/article/f3ba5817649f44478be2ef2467c3502f
Autor:
Travis R. Madaris, Manigandan Venkatesan, Soumya Maity, Miriam C. Stein, Neelanjan Vishnu, Mridula K. Venkateswaran, James G. Davis, Karthik Ramachandran, Sukanthathulse Uthayabalan, Cristel Allen, Ayodeji Osidele, Kristen Stanley, Nicholas P. Bigham, Terry M. Bakewell, Melanie Narkunan, Amy Le, Varsha Karanam, Kang Li, Aum Mhapankar, Luke Norton, Jean Ross, M. Imran Aslam, W. Brian Reeves, Brij B. Singh, Jeffrey Caplan, Justin J. Wilson, Peter B. Stathopulos, Joseph A. Baur, Muniswamy Madesh
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112155- (2023)
Summary: The most abundant cellular divalent cations, Mg2+ (mM) and Ca2+ (nM-μM), antagonistically regulate divergent metabolic pathways with several orders of magnitude affinity preference, but the physiological significance of this competition rem
Externí odkaz:
https://doaj.org/article/324fd2ad3fb9463fa4701a04cb364947
Autor:
Patrick M. Schaefer, Jessica Huang, Arrienne Butic, Caroline Perry, Tal Yardeni, Wendy Tan, Ryan Morrow, Joseph A. Baur, Douglas C. Wallace
Publikováno v:
Molecular Metabolism, Vol 64, Iss , Pp 101560- (2022)
Objective: Mitochondrial disorders are often characterized by muscle weakness and fatigue. Null mutations in the heart-muscle adenine nucleotide translocator isoform 1 (ANT1) of both humans and mice cause cardiomyopathy and myopathy associated with e
Externí odkaz:
https://doaj.org/article/2e90612a35234fd5b829eec167431645
Autor:
Lauren M. Paolella, Sarmistha Mukherjee, Cassie M. Tran, Bruna Bellaver, Mindy Hugo, Timothy S. Luongo, Swapnil V. Shewale, Wenyun Lu, Karthikeyani Chellappa, Joseph A. Baur
Publikováno v:
Molecular Metabolism, Vol 32, Iss , Pp 136-147 (2020)
Objective: Pharmacological agents targeting the mTOR complexes are used clinically as immunosuppressants and anticancer agents and can extend the lifespan of model organisms. An undesirable side effect of these drugs is hyperlipidemia. Although multi
Externí odkaz:
https://doaj.org/article/b5faee1960844042ab6ab3295bfd6258
Autor:
Peter J. Siska, Jing Jiao, Carina Matos, Katrin Singer, Raffaela S. Berger, Katja Dettmer, Peter J. Oefner, Michelle D. Cully, Zhonglin Wang, William J. QuinnIII, Kristen N. Oliff, Benjamin J. Wilkins, Lanette M. Christensen, Liqing Wang, Wayne W. Hancock, Joseph A. Baur, Matthew H. Levine, Ines Ugele, Roman Mayr, Kathrin Renner, Liang Zhou, Marina Kreutz, Ulf H. Beier
Publikováno v:
EBioMedicine, Vol 74, Iss , Pp 103734- (2021)
Background: L-kynurenine is a tryptophan-derived immunosuppressive metabolite and precursor to neurotoxic anthranilate and quinolinate. We evaluated the stereoisomer D-kynurenine as an immunosuppressive therapeutic which is hypothesized to produce le
Externí odkaz:
https://doaj.org/article/707b3408191f474680381251d1043115
Autor:
Anna E. Garcia Whitlock, Jamarie Sostre-Colón, Matthew Gavin, Niels D. Martin, Joseph A. Baur, Carrie A. Sims, Paul M. Titchenell
Publikováno v:
Molecular Metabolism, Vol 51, Iss , Pp 101246- (2021)
Objective: Stress-induced hyperglycemia is associated with poor outcomes in nearly all critical illnesses. This acute elevation in glucose after injury or illness is associated with increased morbidity and mortality, including multiple organ failure.
Externí odkaz:
https://doaj.org/article/acaa1624ec1a4b06ab08ffebf7165105
Autor:
Tomohito Doke, Sarmistha Mukherjee, Dhanunjay Mukhi, Poonam Dhillon, Amin Abedini, James G. Davis, Karthikeyani Chellappa, Beishan Chen, Joseph A. Baur, Katalin Susztak
Publikováno v:
Nature Metabolism. 5:414-430
Autor:
Sarmistha Mukherjee, James Mo, Lauren M. Paolella, Caroline E. Perry, Jade Toth, Mindy M. Hugo, Qingwei Chu, Qian Tong, Karthikeyani Chellappa, Joseph A. Baur
Publikováno v:
JCI Insight, Vol 6, Iss 7 (2021)
Liver regeneration is critical to survival after traumatic injuries, exposure to hepatotoxins, or surgical interventions, yet the underlying signaling and metabolic pathways remain unclear. In this study, we show that hepatocyte-specific loss of the
Externí odkaz:
https://doaj.org/article/5be476c9f2ad4f45a959b3a77c5bb5e1