Zobrazeno 1 - 10
of 487
pro vyhledávání: '"Joseph Sodroski"'
Autor:
Durgadevi Parthasarathy, Karunakar Reddy Pothula, Sneha Ratnapriya, Héctor Cervera Benet, Ruth Parsons, Xiao Huang, Salam Sammour, Katarzyna Janowska, Miranda Harris, Joseph Sodroski, Priyamvada Acharya, Alon Herschhorn
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract HIV-1 envelope glycoproteins (Envs) of most primary HIV-1 strains exist in closed conformation and infrequently sample open states, limiting access to internal epitopes. Thus, immunogen design aims to mimic the closed Env conformation as pre
Externí odkaz:
https://doaj.org/article/586e2ac8dde84379b0e08159c9302824
Autor:
Kunyu Wang, Shijian Zhang, Eden P. Go, Haitao Ding, Wei Li Wang, Hanh T. Nguyen, John C. Kappes, Heather Desaire, Joseph Sodroski, Youdong Mao
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-18 (2023)
Abstract During virus entry, the pretriggered human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer initially transits into a default intermediate state (DIS) that remains structurally uncharacterized. Here, we present cryo-EM struc
Externí odkaz:
https://doaj.org/article/5183390ce11740eba560933fba8b9a2a
Autor:
Pengfei Wang, Lihong Liu, Manoj S. Nair, Michael T. Yin, Yang Luo, Qian Wang, Ting Yuan, Kanako Mori, Axel Guzman Solis, Masahiro Yamashita, Ankur Garg, Lawrence J. Purpura, Justin C. Laracy, Jian Yu, Leemor Joshua-Tor, Joseph Sodroski, Yaoxing Huang, David D. Ho
Publikováno v:
Emerging Microbes and Infections, Vol 9, Iss 1, Pp 2091-2093 (2020)
ABSTRACTWe studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease. Likewise, mean
Externí odkaz:
https://doaj.org/article/da46bcc788814f82bbeaca8fe4b003cb
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-17 (2019)
Abstract Background The detection of weak signals and selection of single particles from low-contrast micrographs of frozen hydrated biomolecules by cryo-electron microscopy (cryo-EM) represents a major practical bottleneck in cryo-EM data analysis.
Externí odkaz:
https://doaj.org/article/ef20c44775ee4726a93744698ddacd2f
Autor:
Yen-Ting Lai, Tao Wang, Sijy O’Dell, Mark K. Louder, Arne Schön, Crystal S. F. Cheung, Gwo-Yu Chuang, Aliaksandr Druz, Bob Lin, Krisha McKee, Dongjun Peng, Yongping Yang, Baoshan Zhang, Alon Herschhorn, Joseph Sodroski, Robert T. Bailer, Nicole A. Doria-Rose, John R. Mascola, David R. Langley, Peter D. Kwong
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Temsavir, a compound that inhibits HIV entry by binding envelope (Env), is currently in clinical development. Here, Lai et al. identify a more than 10-fold improved compound and, using lattice engineering, obtain crystal structures that give insights
Externí odkaz:
https://doaj.org/article/8c1780f80cef41df909afde553e1a2ab
Autor:
Jérémie Prévost, William D. Tolbert, Halima Medjahed, Rebekah T. Sherburn, Navid Madani, Daria Zoubchenok, Gabrielle Gendron-Lepage, Althea E. Gaffney, Melissa C. Grenier, Sharon Kirk, Natasha Vergara, Changze Han, Brendan T. Mann, Agnès L. Chénine, Adel Ahmed, Irwin Chaiken, Frank Kirchhoff, Beatrice H. Hahn, Hillel Haim, Cameron F. Abrams, Amos B. Smith, Joseph Sodroski, Marzena Pazgier, Andrés Finzi
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT The HIV-1 envelope glycoproteins (Env) undergo conformational changes upon interaction of the gp120 exterior glycoprotein with the CD4 receptor. The gp120 inner domain topological layers facilitate the transition of Env to the CD4-bound conf
Externí odkaz:
https://doaj.org/article/c4fa9bf5772f469680b5dab67aad98e5
Autor:
Navid Madani, Amy M. Princiotto, Linh Mach, Shilei Ding, Jérémie Prevost, Jonathan Richard, Bhavna Hora, Laura Sutherland, Connie A. Zhao, Brandon P. Conn, Todd Bradley, M. Anthony Moody, Bruno Melillo, Andrés Finzi, Barton F. Haynes, Amos B. Smith III, Sampa Santra, Joseph Sodroski
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
The HIV Env trimer exhibits a closed confirmation and restricts access to known antibody binding sites. Here the authors show that a small-molecule CD4-mimetic compound binds the HIV Env trimer and enhances antibody-mediated protection in a non-human
Externí odkaz:
https://doaj.org/article/ac213354426e4f05910a41474b6a0b00
Autor:
Christopher Fritschi, Saumya Anang, Zhen Gong, Mohammadjavad Mohammadi, Jonathan Richard, Catherine Bourassa, Kenny T. Severino, Hannah Richter, Derek Yang, Hung-Ching Chen, Ta-Jung Chiu, Michael Seaman, Navid Madani, Cameron Abrams, Andrés Finzi, Wayne A. Hendrickson, Joseph Sodroski, Amos B. Smith
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Binding to the host cell receptors, CD4 and CCR5/CXCR4, triggers large-scale conformational changes in the human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer [(gp120/gp41)3] that promote virus entry into the cell. CD4-mimetic com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52fed5f5da2d8fba7782b185b3b3cf3
https://doi.org/10.1073/pnas.2222073120
https://doi.org/10.1073/pnas.2222073120
Autor:
Todd Bradley, Ashley Trama, Nancy Tumba, Elin Gray, Xiaozhi Lu, Navid Madani, Fatemeh Jahanbakhsh, Amanda Eaton, Shi-Mao Xia, Robert Parks, Krissey E. Lloyd, Laura L. Sutherland, Richard M. Scearce, Cindy M. Bowman, Susan Barnett, Salim S. Abdool-Karim, Scott D. Boyd, Bruno Melillo, Amos B. Smith III, Joseph Sodroski, Thomas B. Kepler, S.Munir Alam, Feng Gao, Mattia Bonsignori, Hua-Xin Liao, M. Anthony Moody, David Montefiori, Sampa Santra, Lynn Morris, Barton F. Haynes
Publikováno v:
EBioMedicine, Vol 12, Iss C, Pp 196-207 (2016)
Most HIV-1 vaccines elicit neutralizing antibodies that are active against highly sensitive (tier-1) viruses or rare cases of vaccine-matched neutralization-resistant (tier-2) viruses, but no vaccine has induced antibodies that can broadly neutralize
Externí odkaz:
https://doaj.org/article/70ba80d336514e81baec839d541fe0d3
Autor:
Jonathan Richard, Beatriz Pacheco, Neelakshi Gohain, Maxime Veillette, Shilei Ding, Nirmin Alsahafi, William D. Tolbert, Jérémie Prévost, Jean-Philippe Chapleau, Mathieu Coutu, Manxue Jia, Nathalie Brassard, Jongwoo Park, Joel R. Courter, Bruno Melillo, Loïc Martin, Cécile Tremblay, Beatrice H. Hahn, Daniel E. Kaufmann, Xueling Wu, Amos B. Smith III, Joseph Sodroski, Marzena Pazgier, Andrés Finzi
Publikováno v:
EBioMedicine, Vol 12, Iss C, Pp 208-218 (2016)
Human immunodeficiency virus type 1 (HIV-1) has evolved a sophisticated strategy to conceal conserved epitopes of its envelope glycoproteins (Env) recognized by antibody-dependent cellular cytotoxicity (ADCC)-mediating antibodies. These antibodies, w
Externí odkaz:
https://doaj.org/article/ee6c30dcd51740f589ceca78a336e2ea