Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Joseph Sisko"'
Publikováno v:
Tetrahedron Letters. 52:4207-4210
A two-step procedure is described to access 3-alkoxycyclobutanones from chloroacetyl chloride utilizing a step-wise [2+2] ketene cycloaddition followed by catalytic hydrogenation to reduce the α-chlorine in a single reaction sequence. The resulting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e2310f9ebf5fce97d279db2cb775453
https://doi.org/10.1016/j.tetlet.2011.06.027
https://doi.org/10.1016/j.tetlet.2011.06.027
Autor:
Frederick G. Vogt, Yemane W. Andemichael, Sonja Sharpe, Lori Wernersbach, Susan V. Downing, Daniel B. Patience, Julie Tsui, Peng Liu, Lynette M. Oh, Wenning Dai, Jacalyn S. Clawson, Leon Zhou, James T. Wertman, Alan J. Freyer, Joseph Sisko, Jun Chen, Jun Wang, Edward C. Webb, Diederich Ann M
Publikováno v:
Organic Process Research & Development. 13:729-738
A scalable synthesis of a novel pleuromutilin-based antibiotic is reported. The synthesis features the scale-up of an interesting skeletal rearrangement of the pleuromutilin core and isolation of a highly purified product despite starting with relati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1c091505eda6c4da66da24f77dd243d
https://doi.org/10.1021/op900104g
https://doi.org/10.1021/op900104g
Autor:
Alan D. Jones, Joseph Sisko, Tran N. Pham, Matthew N. Johnson, Jeffrey Brum, Wenning Dai, Daniel B. Patience, Jacalyn S. Clawson, Royston C. P. Copley, Sonja Sharpe, Frederick G. Vogt
Publikováno v:
Crystal Growth & Design. 8:4120-4131
An unusual pharmaceutical solid containing a pleuromutilin derivative, succinic acid and water is studied with a combination of physiochemical methods. The parent pleuromutilin derivative creates a host structure that contains large channels, which a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aba3aac6ef68379580615d830daf9166
https://doi.org/10.1021/cg8005713
https://doi.org/10.1021/cg8005713
Autor:
Daniel B. Patience, Lynette M. Oh, Huan Wang, Joseph Sisko, P. Grant Spoors, Robert E. Herrmann, Susan Shilcrat
Publikováno v:
Organic Process Research & Development. 11:1032-1042
A scalable synthesis of GSK183390A, a PPAR α/γ agonist, is described. This synthesis is highlighted by (1) a regioselective formal 1,3-dipolar cycloaddition reaction between an enamine and a nitrile imine dipole to form a 1,3,5-trisubstituted pyraz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f899fde00e5f2a1dd470adcc0803e088
https://doi.org/10.1021/op700164t
https://doi.org/10.1021/op700164t
Autor:
Joseph Sisko, Mellinger Mark
Publikováno v:
Pure and Applied Chemistry. 74:1349-1357
Several highly substituted imidazoles have been under investigation at GlaxoSmithKline as potential therapies for the treatment of rheumatoid arthritis and have spawned the need for a general synthetic method for their preparation on a multikilogram
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::056452374e77b83490fb6da5c8312486
https://doi.org/10.1351/pac200274081349
https://doi.org/10.1351/pac200274081349
Publikováno v:
Rapid Communications in Mass Spectrometry. 15:1548-1553
Time-resolved electrospray ionization mass spectrometry (ESI-MS) is a powerful tool for interrogating solution-phase reaction systems. Both mechanistic and kinetic information can be obtained using this technique. The title reaction offers the opport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbb59ce67c3a4f7cd5820f6e1bd2644d
https://doi.org/10.1002/rcm.403
https://doi.org/10.1002/rcm.403
Autor:
Joseph Sisko, Andrew J. Kassick, Andrew J. Allen, Mark A. Olsen, Mark Mellinger, John J. Filan
Publikováno v:
The Journal of Organic Chemistry. 65:1516-1524
This article describes efficient and mild protocols for preparing polysubstituted imidazoles in a single pot from aryl-substituted tosylmethyl isocyanide (TosMIC) reagents and imines generated in situ. Traditional imine-forming reactions employing vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ce27d3c8325666166c5910ed4bf03b4
https://doi.org/10.1021/jo991782l
https://doi.org/10.1021/jo991782l
Publikováno v:
Tetrahedron Letters. 37:8113-8116
Substituted tosylmethyl isocyanides (TosMICs) are useful reagents for which no general method of preparation is available. We describe here a high-yielding method for the synthesis of substituted tosylmethyl formamides, which are readily converted to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce36e650b3298e351f7ca389f8eb9fbb
https://doi.org/10.1016/0040-4039(96)01886-2
https://doi.org/10.1016/0040-4039(96)01886-2
Autor:
Steven M. Weinreb, Joseph Sisko, Robert M. Borzilleri, Andrew M. Klos, Masood Parvez, John P. Cherkauskas
Publikováno v:
Tetrahedron. 52:3135-3152
Condensation of β-hydroxy aldehydes with N-sulfonyl aldimines produces 3,6-dihydro-2H-1,3-oxazines in moderate to excellent yields. The process is stereoselective, with the C-2 and C-6 substituents having a trans relationship in these heterocycles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a15e06d829c2e47948d3645739ab8704
https://doi.org/10.1016/0040-4020(95)01100-5
https://doi.org/10.1016/0040-4020(95)01100-5
Publikováno v:
ChemInform. 43
A three-step procedure to access fused pyridines has been developed utilizing inexpensive amino acids and alkenols to form the key oxazole precursors. Yields are good to excellent and provide a rapid and inexpensive route to a range of pharmacologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28371e5336b7b9879cd2bca9ede70aa5
https://doi.org/10.1002/chin.201228197
https://doi.org/10.1002/chin.201228197