Výsledky vyhledávání - "Joseph M. Salvino"

Akademický článek

Investigation of some plant stilbenoids and their fragments for the identification of inhibitors of SARS-CoV-2 viral spike/ACE2 protein binding

Autor: Cyril T. Namba-Nzanguim, Conrad V. Simoben, Boris D. Bekono, Ian Tietjen, Joel Cassel, Joseph M. Salvino, Luis J. Montaner, Rohan A. Davis, Fidele Ntie-Kang

Publikováno v: The Microbe, Vol 3, Iss , Pp 100059- (2024)

In silico binding studies were conducted on the known plant-derived polyphenolic tetrameric stilbenoids, (–)-hopeaphenol (1), vaticanol B (2) and vatalbinoside A (3) and their monomeric derivative resveratrol (8), identified from several plant spec

Externí odkaz: https://doaj.org/article/afc2075cc7264f5a8d0c9e22bd2b420d

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Akademický článek

Elevated pre-mRNA 3′ end processing activity in cancer cells renders vulnerability to inhibition of cleavage and polyadenylation

Autor: Yange Cui, Luyang Wang, Qingbao Ding, Jihae Shin, Joel Cassel, Qin Liu, Joseph M. Salvino, Bin Tian

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)

Abstract Cleavage and polyadenylation (CPA) is responsible for 3′ end processing of eukaryotic poly(A)+ RNAs and preludes transcriptional termination. JTE-607, which targets CPSF-73, is the first known CPA inhibitor (CPAi) in mammalian cells. Here

Externí odkaz: https://doaj.org/article/e9b3e1159ab1464199de78e8383a1b46

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Akademický článek

Increased glucose availability sensitizes pancreatic cancer to chemotherapy

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Abstract Pancreatic Ductal Adenocarcinoma (PDAC) is highly resistant to chemotherapy. Effective alternative therapies have yet to emerge, as chemotherapy remains the best available systemic treatment. However, the discovery of safe and available adju

Externí odkaz: https://doaj.org/article/d2faef86ea85483498c70286f6d2ac00

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Akademický článek

Recent Advances in Metal-Catalyzed Approaches for the Synthesis of Quinazoline Derivatives

Autor: Nitesh K. Nandwana, Om P. S. Patel, Manish K. Mehra, Anil Kumar, Joseph M. Salvino

Publikováno v: Molecules, Vol 29, Iss 10, p 2353 (2024)

Quinazolines are an important class of heterocyclic compounds that have proven their significance, especially in the field of organic synthesis and medicinal chemistry because of their wide range of biological and pharmacological properties. Thus, nu

Externí odkaz: https://doaj.org/article/fe0e1c141f034dbd9e2c88b75375896d

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Akademický článek

Immune Responses of a Novel Bi-Cistronic SARS-CoV-2 DNA Vaccine Following Intradermal Immunization With Suction Delivery

Publikováno v: Frontiers in Virology, Vol 2 (2022)

SARS-CoV-2 is the third pathogenic coronavirus to emerge since 2000. Experience from prior outbreaks of SARS-CoV and MERS-CoV has demonstrated the importance of both humoral and cellular immunity to clinical outcome, precepts that have been recapitul

Externí odkaz: https://doaj.org/article/c73deb36ca654fa2815416d4cd1e4dd1

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Akademický článek

Synthesis of both enantiomers and the 13C derivative of CPI-2850, the major metabolite of Devimistat

Autor: Poli Adi Narayana Reddy, Zachary Stine, Joseph M. Salvino

Publikováno v: Results in Chemistry, Vol 4, Iss , Pp 100268- (2022)

A practical synthesis of CPI-2850, the major metabolite of Devimistat (CPI-613® (6,8-bis-benzylsulfanyloctanoic acid)), has been developed to synthesize multigram quantities for enantiomeric separation. Using enantioenriched (S)-(−)-1,2,4-butanetr

Externí odkaz: https://doaj.org/article/d45f776382614e7ca85134c3d5fb0c8c

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