Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Joseph H. Chan"'
Autor:
G S Lowell, John Milton, David I. Stuart, Joseph H. Chan, George Andrew Freeman, S S Gonzales, Steven A. Short, Jingshan Ren, Andrew L. Hopkins, K L Creech, Richard J. Hazen, R G Ferris, G W Koszalka, L T Schaller, G B Roberts, Cowan, C W Andrews Iii, Kurt Weaver, L R Boone, David K. Stammers, D J Reynolds
HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) are part of the combination therapy currently used to treat HIV infection. The features of a new NNRTI drug for HIV treatment must include selective potent activity against both wild-type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba0381a0617d10120e121697f22e025
https://doi.org/10.1021/jm040072r
https://doi.org/10.1021/jm040072r
Autor:
P.P. Chamberlain, Steven A. Short, Joseph H. Chan, C.E. Nichols, Jingshan Ren, Kurt Weaver, David K. Stammers, Jörg-Peter Kleim
The selection of drug resistant viruses is a major problem in efforts to combat HIV and AIDS, hence, new compounds are required. We report crystal structures of wild-type and mutant HIV-1 RT with bound non-nucleoside (NNRTI) GW420867X, aimed at inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5aa2452484a62bd3c23c20596e0d14
https://doi.org/10.1021/jm061117m
https://doi.org/10.1021/jm061117m
Autor:
Richard J. Hazen, Joseph H. Chan, David K. Stammers, Jingshan Ren, David I. Stuart, John Milton, Andrew L. Hopkins
We have used a structure-based approach to design a novel series of non-nucleoside inhibitors of HIV-1 RT (NNRTIs). Detailed analysis of a wide range of crystal structures of HIV-1 RT-NNRTI complexes together with data on drug resistance mutations ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0c99ad4eb1da012b70ce4d87a86241
https://ora.ox.ac.uk/objects/uuid:259aabc9-ef6d-4ae0-9ae8-fb0ff77c9ccc
https://ora.ox.ac.uk/objects/uuid:259aabc9-ef6d-4ae0-9ae8-fb0ff77c9ccc
Autor:
Kurt Weaver, Jingshan Ren, L R Boone, R G Ferris, A Freeman, Steven A. Short, Anna Stamp, Richard J. Hazen, K.R Romines, C W Andrews Iii, P.P. Chamberlain, David K. Stammers, Joseph H. Chan
Publikováno v:
Journal of Medicinal Chemistry. 51:5000-5008
Owing to the emergence of resistant virus, next generation non-nucleoside HIV reverse transcriptase inhibitors (NNRTIs) with improved drug resistance profiles have been developed to treat HIV infection. Crystal structures of HIV-1 RT complexed with b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::832c8ffe10f26487effda5730a48ae45
https://doi.org/10.1021/jm8004493
https://doi.org/10.1021/jm8004493
Autor:
Jeffrey H. Tidwell, George Andrew Freeman, Marty St. Clair, Robert G. Ferris, Lee T. Schaller, Dean W. Selleseth, Steven A. Short, Jill R. Cowan, Lawrence R. Boone, Kurt Weaver, G B Roberts, Joseph H. Chan, Richard J. Hazen, Kelly R. Moniri, Karen Rene Romines
Publikováno v:
Antimicrobial Agents and Chemotherapy. 49:4046-4051
The compound GW678248 is a novel benzophenone nonnucleoside reverse transcriptase inhibitor (NNRTI). Preclinical assessment of GW678248 indicates that this compound potently inhibits wild-type (WT) and mutant human immunodeficiency virus type 1 (HIV-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4865655b25dbfbe07da6cb52e75ed9fb
https://doi.org/10.1128/aac.49.10.4046-4051.2005
https://doi.org/10.1128/aac.49.10.4046-4051.2005
Autor:
Lee F. Kuyper, Karl D. Hardman, Robert L. Tansik, Jean S. Hong, David Stewart, Marc Whitlow, Joseph H. Chan, Andrew J. Howard, David P. Baccanari
Publikováno v:
Journal of Medicinal Chemistry. 44:2928-2932
X-ray crystallographic analysis of 5-(4'-substituted phenyl)sulfanyl-2,4-diaminoquinazoline inhibitors in ternary complex with Candida albicans dihydrofolate reductase (DHFR) and NADPH revealed two distinct modes of binding. The two compounds with sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9280f132de00963466761d27b1ea5fc
https://doi.org/10.1021/jm0101444
https://doi.org/10.1021/jm0101444
Autor:
Lloyd Frick, John C. Drach, Joseph H. Chan, Dean W. Selleseth, Stanley D. Chamberlain, George W. Koszalka, Ernest H. Dark, Robert J. Harvey, Karen K. Biron, Leroy B. Townsend, R E Dornsife, Michelle G. Davis
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 19:101-123
A series of 2'-deoxy analogues of the antiviral agent 5,6-dichloro-2-isopropylamino-1-(beta-L-ribofuranosyl)-1H-benzimidazole (1263W94) were synthesized and evaluated for activity against human cytomegalovirus (HCMV) and for cytotoxicity. The 2-subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e3c56352778834b481dfb60df98d2e
https://doi.org/10.1080/15257770008032999
https://doi.org/10.1080/15257770008032999
Autor:
Sharon K. Rudolph, Lee F. Kuyper, Christine M. Boytos, Joseph H. Chan, David P. Baccanari, Jean S. Hong, Robert L. Tansik, Andrew D. Brown, Michael L. Jones
Publikováno v:
Journal of Heterocyclic Chemistry. 34:145-151
A series of novel 1,3-diamino-7,8,9,10-tetrahydropyrido[3,2-f]quinazolines were synthesized starting from 6-amino-5-cyanoquinoline (4). These compounds inhibited Candida albicans dihydrofolate reductase with Ki values of ≤0.60 aM. One analogue exhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c15aa29c9097543765be38f6904484e
https://doi.org/10.1002/jhet.5570340123
https://doi.org/10.1002/jhet.5570340123
Autor:
Wan Gang Gu, David Chi Cheong Wan, Sijie Liu, Xuan Zhang, Yan Wang, Yong-Tang Zheng, Joseph H. Chan, Denis Tsz-Ming Ip
Publikováno v:
Chemico-biological interactions. 213
Translocation of viral integrase (IN) into the nucleus is a critical precondition of integration during the life cycle of HIV, a causative agent of Acquired Immunodeficiency Syndromes (AIDS). As the first discovered cellular factor to interact with I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477c48bd89bc678a98af2375f0869b22
https://pubmed.ncbi.nlm.nih.gov/24480521
https://pubmed.ncbi.nlm.nih.gov/24480521
Autor:
Robert L. Tansik, Sharon K. Rudolph, Christine M. Boytos, Virgil L. Styles, Joseph H. Chan, G. Erik Jagdmann
Publikováno v:
Journal of Heterocyclic Chemistry. 32:1461-1465
Several 5-(4-substituted benzyl)-2,4-diaminoquinazolines were prepared as potentially selective inhibitors of Candida albicans dihydrofolate reductase. These compounds were synthesized by a novel route, which included as a key step the displacement o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a57b311d2226b1046ec5d462af4ec66
https://doi.org/10.1002/jhet.5570320508
https://doi.org/10.1002/jhet.5570320508