Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Joseph, Negri"'
Autor:
Yi-Chen Hsieh, Joseph Negri, Amy He, Richard V. Pearse, Lei Liu, Duc M. Duong, Lori B. Chibnik, David A. Bennett, Nicholas T. Seyfried, Tracy L. Young-Pearse
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-23 (2022)
Abstract Background Alzheimer’s Disease (AD) affects millions globally, but therapy development is lagging. New experimental systems that monitor neuronal functions in conditions approximating the AD brain may be beneficial for identifying new ther
Externí odkaz:
https://doaj.org/article/6be3dc2f5fd24619b28eb8ec75d45782
Autor:
Constantine S. Mitsiades, Kenneth C. Anderson, Paul G. Richardson, Nikhil C. Munshi, Robert Schlossman, Carlos Garcia-Echeverria, Sauveur-Michel Maira, Jana Jakubikova, Nicolas Mitsiades, Patrick Hayden, Joseph Negri, Jake Delmore, Melissa Ooi, Douglas W. McMillin
Supplementary Figures 1-7 from Antimyeloma Activity of the Orally Bioavailable Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28cb2ca9dec69860d50dd86a4e5554b1
https://doi.org/10.1158/0008-5472.22378757.v1
https://doi.org/10.1158/0008-5472.22378757.v1
Autor:
Yi‐Chen Hsieh, Joseph Negri, Amy He, Richard V Pearse II, Lei Liu, Duc M. Duong, Lori B. Chibnik, David A Bennett, Nicholas T. Seyfried, Tracy Young‐Pearse
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bad55b54c0a46e5d7ba5953e534f20d
https://doi.org/10.1002/alz.059823
https://doi.org/10.1002/alz.059823
Autor:
Marek M Nagiec, Adam P Skepner, Joseph Negri, Michelle Eichhorn, Nicolas Kuperwasser, Eamon Comer, Giovanni Muncipinto, Aravind Subramanian, Clary Clish, Kiran Musunuru, Jeremy R Duvall, Michael Foley, Jose R Perez, Michelle A J Palmer
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120295 (2015)
Recent genome wide association studies have linked tribbles pseudokinase 1 (TRIB1) to the risk of coronary artery disease (CAD). Based on the observations that increased expression of TRIB1 reduces secretion of VLDL and is associated with lower plasm
Externí odkaz:
https://doaj.org/article/462e5962fcb24652928b7b20d53c53e5
Autor:
Tracy L. Young-Pearse, Ulf Dettmer, Thibaut Imberdis, Elizabeth Terry-Kantor, Dennis J. Selkoe, Oren A. Levy, Tae-Eun Kim, Saranna Fanning, Gary P.H. Ho, Georgia L. Stirtz, Joseph Negri, Nagendran Ramalingam
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Misfolding and accumulation of the protein α-synuclein (αS) inside nerve cells characterize Parkinson’s disease (PD) and related brain diseases, for which no disease-modifying therapies exist. Robust cell models are needed that recap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4501e0548e0147d5434121663847b8e
https://doi.org/10.1073/pnas.1903216116
https://doi.org/10.1073/pnas.1903216116
Publikováno v:
eNeuro
Multi-electrode arrays (MEAs) are being more widely used by researchers as an instrument platform for monitoring prolonged, non-destructive recordings of spontaneously firing neuronsin vitrofor applications in modeling Alzheimer’s, Parkinson’s, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79dcc273715f55b1932aa7e35b9710ba
http://europepmc.org/articles/PMC6984810
http://europepmc.org/articles/PMC6984810
Autor:
Toshimori Kitami, David J Logan, Joseph Negri, Thomas Hasaka, Nicola J Tolliday, Anne E Carpenter, Bruce M Spiegelman, Vamsi K Mootha
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33755 (2012)
The cellular content of mitochondria changes dynamically during development and in response to external stimuli, but the underlying mechanisms remain obscure. To systematically identify molecular probes and pathways that control mitochondrial abundan
Externí odkaz:
https://doaj.org/article/0ec69c65a6e74dac86d09895c7a34ac6
Autor:
Jana Jakubikova, David Cervi, Melissa Ooi, Kihyun Kim, Sabikun Nahar, Steffen Klippel, Dana Cholujova, Merav Leiba, John F. Daley, Jake Delmore, Joseph Negri, Simona Blotta, Douglas W. McMillin, Teru Hideshima, Paul G. Richardson, Jan Sedlak, Kenneth C. Anderson, Constantine S. Mitsiades
Publikováno v:
Haematologica, Vol 96, Iss 8 (2011)
Background Isothiocyanates, a family of phytochemicals found in cruciferous vegetables, have cytotoxic effects against several types of tumor cells. Multiple myeloma is a fatal disease characterized by clonal proliferation of plasma cells in the bone
Externí odkaz:
https://doaj.org/article/6ecdffc9d691420c9800454442ed5225
Autor:
Douglas W McMillin, Jake Delmore, Joseph Negri, Melissa Ooi, Steffen Klippel, Chandrasekhar V Miduturu, Nathanael S Gray, Paul G Richardson, Kenneth C Anderson, Andrew L Kung, Constantine S Mitsiades
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e20226 (2011)
Polo-like kinases (PLKs) play an important role in cell cycle progression, checkpoint control and mitosis. The high mitotic index and chromosomal instability of advanced cancers suggest that PLK inhibitors may be an attractive therapeutic option for
Externí odkaz:
https://doaj.org/article/04c02c07f07a4c62af5036b743395d86
Autor:
Marek M, Nagiec, Jeremy R, Duvall, Adam P, Skepner, Eleanor A, Howe, Jessica, Bastien, Eamon, Comer, Jean-Charles, Marie, Stephen E, Johnston, Joseph, Negri, Michelle, Eichhorn, Julien, Vantourout, Clary, Clish, Kiran, Musunuru, Michael, Foley, Jose R, Perez, Michelle A J, Palmer
Publikováno v:
MedChemComm. 9(11)
Increased expression of the Tribbles pseudokinase 1 gene (TRIB1) is associated with lower plasma levels of LDL cholesterol and triglycerides, higher levels of HDL cholesterol and decreased risk of coronary artery disease and myocardial infarction. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22e105aa4f33d9ef4ee264e0519ebeba
https://pubmed.ncbi.nlm.nih.gov/30542533
https://pubmed.ncbi.nlm.nih.gov/30542533