Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Joseph, Brock"'
Autor:
Iven Winkelmann, Povilas Uzdavinys, Ian M. Kenney, Joseph Brock, Pascal F. Meier, Lina-Marie Wagner, Florian Gabriel, Sukkyeong Jung, Rei Matsuoka, Christoph von Ballmoos, Oliver Beckstein, David Drew
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
By determining the crystal structure of the Na + /H + antiporter NhaA at active pH, the authors show how substrate accessibility to the ion-binding site can be controlled by pH sensitive switch located on the cytoplasmic surface.
Externí odkaz:
https://doaj.org/article/d75c94092f084db7b84a655abf5cc842
Autor:
Iven, Winkelmann, Povilas, Uzdavinys, Ian M, Kenney, Joseph, Brock, Pascal F, Meier, Lina-Marie, Wagner, Florian, Gabriel, Sukkyeong, Jung, Rei, Matsuoka, Christoph, von Ballmoos, Oliver, Beckstein, David, Drew
Publikováno v:
Nature communications. 13(1)
The strict exchange of protons for sodium ions across cell membranes by Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1b2a0265815de73fb3bb7019e84cad91
https://pubmed.ncbi.nlm.nih.gov/36289233
https://pubmed.ncbi.nlm.nih.gov/36289233
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60324 (2013)
Glutathione transferases (GSTs) are dimeric enzymes containing one active-site per monomer. The omega-class GSTs (hGSTO1-1 and hGSTO2-2 in humans) are homodimeric and carry out a range of reactions including the glutathione-dependant reduction of a r
Externí odkaz:
https://doaj.org/article/1e81778efc344752af6c13c8ddd1ebd2
Publikováno v:
OSA Advanced Photonics Congress (AP) 2020 (IPR, NP, NOMA, Networks, PVLED, PSC, SPPCom, SOF).
We present the design and preliminary experimental results of a novel silicon nitride polarization beam splitter. Measured data show that a 33 dB polarization extinction ratio is achieved over a bandwidth of 18 nm.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22b86066586393ddd09321896324a972
https://doi.org/10.1364/iprsn.2020.jth2a.4
https://doi.org/10.1364/iprsn.2020.jth2a.4
Autor:
Sarah E McComas, Albert Suades, Laura Orellana, Joseph Brock, Abdul Aziz Qureshi, Magnus Claesson, Rei Matsuoka, Lucie Delemotte, Emmanuel Nji, David A. Drew
Publikováno v:
Nature. 578(7794)
Elucidating the mechanism of sugar import requires a molecular understanding of how transporters couple sugar binding and gating events. Whereas mammalian glucose transporters (GLUTs) are specialists1, the hexose transporter from the malaria parasite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a879936407e966ebda5bb10c1c53701d
https://pubmed.ncbi.nlm.nih.gov/32042087
https://pubmed.ncbi.nlm.nih.gov/32042087
Publikováno v:
Optics Express. 29:14476
We present the design and experimental results of a novel polarization beam splitter (PBS) with a high polarization extinction ratio (PER) made on a Si3N4 platform. The PBS is composed of two identical polarization-independent multi-mode interferomet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c21822874f98a63e13d159728400ac32
https://doi.org/10.1364/oe.420499
https://doi.org/10.1364/oe.420499
Autor:
Jerker Widengren, Madhuranayaki Thulasingam, Bengt Mannervik, Hiroshi Abe, Ralf Morgenstern, Marcus Cebula, Joseph Brock, Birgitta Sjödin, Agnes Rinaldo-Matthis, Ilke Simsek Turan, Engin U. Akkaya, Jesper Z. Haeggström, Volodymyr Chmyrov
Publikováno v:
Scientific Reports
Both soluble and membrane-bound enzymes can catalyze the conversion of lipophilic substrates. The precise substrate access path, with regard to phase, has however, until now relied on conjecture from enzyme structural data only (certainly giving cred
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341847b736538aabfd05e77af6ae5e76
https://pubmed.ncbi.nlm.nih.gov/27917951
https://pubmed.ncbi.nlm.nih.gov/27917951
Autor:
Bengt Samuelsson, Joseph Brock, Michael C. Goodman, Navisraj Balagunaseelan, Agnes Rinaldo-Matthis, Emilia Strandback, Mats Hamberg, Jesper Z. Haeggström, Ralf Morgenstern
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(4)
Microsomal prostaglandin E2 synthase type 1 (mPGES-1) is responsible for the formation of the potent lipid mediator prostaglandin E2 under proinflammatory conditions, and this enzyme has received considerable attention as a drug target. Recently, a h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f02e809221ebdf9e4b82ca4655e7a9
https://pubmed.ncbi.nlm.nih.gov/26755582
https://pubmed.ncbi.nlm.nih.gov/26755582
Publikováno v:
Journal of Molecular Biology. 420:190-203
The reduction of dehydroascorbate (DHA) to ascorbic acid (AA) is a vital cellular function. The omega-class glutathione transferases (GSTs) catalyze several reductive reactions in cellular biochemistry, including DHA reduction. In humans, two isozyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228ce65f3b0a64086ba7f1e6a9af5b90
https://doi.org/10.1016/j.jmb.2012.04.014
https://doi.org/10.1016/j.jmb.2012.04.014
Publikováno v:
Journal of Biological Chemistry. 286:4271-4279
The polymorphic deletion of Glu-155 from human glutathione transferase omega1 (GSTO1-1) occurs in most populations. Although the recombinant ΔGlu-155 enzyme expressed in Escherichia coli is active, the deletion causes a deficiency of the active enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8c4c976a0572c875233cc9b78bfc33
https://doi.org/10.1074/jbc.m110.197822
https://doi.org/10.1074/jbc.m110.197822