Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Josep Maria Caba"'
Autor:
Carmen Cuevas, Carol Gracia, Josep Maria Caba, Fernando Albericio, Marta Carrascal, Angel López-Macià, Jimenez Jose Carlos, Sonia Varón, Andrés Francesch, Ernest Giralt, Miriam Royo
Publikováno v:
Journal of Medicinal Chemistry. 51:4920-4931
Kahalalide F (KF) is a natural product currently under phase II clinical trials. Here, we report the solid phase synthesis of 132 novel analogues of kahalalide F and their in vitro activity on a panel of up to 14 cancer cell lines. The structure-acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86b0f6b3b525f286c1e1b0ceebf8f5d
https://doi.org/10.1021/jm8000828
https://doi.org/10.1021/jm8000828
Autor:
Ernest Giralt, Fernando Albericio, Esther Zurita, Marc Martinell, Meritxell Teixidó, Marta Vilaseca, Roger Prades, Josep Maria Caba
Publikováno v:
International Journal of Peptide Research and Therapeutics. 13:313-327
At the beginning of the XXI century, 43 years after the description of the first solid-phase synthesis of a tetrapeptide by Bruce Merrifield, the synthesis of a tetrapeptide may still represent a synthetic challenge. This is the case of serratamolide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e061294bfd2b588b302f658fd732535e
https://doi.org/10.1007/s10989-007-9086-z
https://doi.org/10.1007/s10989-007-9086-z
Publikováno v:
The Journal of Organic Chemistry. 68:211-215
Trunkamide A (1) is a cyclic heptapeptide extracted from the ascidian Lissoclinum sp. and has shown very promising cytotoxic activity. This compound incorporates several of the motifs commonly observed in the Patellin family, including dimethylallyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e8c293f2548585fb8268747cfc2a66f
https://doi.org/10.1021/jo026464s
https://doi.org/10.1021/jo026464s
Publikováno v:
The Journal of Organic Chemistry. 66:7568-7574
Marine organisms are a rich source of novel, biologically active compounds. Herein, the solid-phase total synthesis of trunkamide A, currently in preclinical trials, is presented. Trunkamide A contains a thiazoline heterocycle and two residues of Ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd57ee5128c7f2d3e7388906c4f1378
https://doi.org/10.1021/jo015703t
https://doi.org/10.1021/jo015703t
Autor:
Miguel Feliz, Paul Lloyd-Williams, Francisco Cárdenas, Ernest Giralt, Michael Thormann, Josep-Maria Caba
Publikováno v:
The Journal of Organic Chemistry. 66:4580-4584
Dehydrodidemnin B (DDB or aplidine), a potent antitumoral natural product currently in phase II clinical trials, exists as an approximately 1:1 mixture of two slowly interconverting conformations. These are sufficiently long-lived so as to allow thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1b4274a02351e80d3944c84433451a8
https://doi.org/10.1021/jo010123h
https://doi.org/10.1021/jo010123h
Autor:
Paul Lloyd-Williams, Isabel González, Ernest Giralt, Fernando Albericio, Gemma Jou, Josep Maria Caba
Publikováno v:
Scopus-Elsevier
The syntheses of the two protected derivatives 7 and 16 of (2S,4S)-4-hydroxy-2,5-dimethyl-3-oxohexanoic acid, a constituent of the didemnin family of antineoplastic macrocyclic depsipeptides are described. The preparation of 7 was carried out by modi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b22ffe07dac91082099c1c91d032a8
https://doi.org/10.1039/p19960001427
https://doi.org/10.1039/p19960001427
Publikováno v:
The Journal of organic chemistry. 68(25)
Aplidine (dehydrodidemnin B), a natural product with potent antitumor activity currently in multicenter phase II clinical trials, exists in DMSO as a mixture of four slowly interconverting conformations in a ratio of 47:33:13:7. NMR spectroscopy show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a33c5d867424bee03530bb72a85bad54
https://pubmed.ncbi.nlm.nih.gov/14656079
https://pubmed.ncbi.nlm.nih.gov/14656079
Autor:
Laia Solé, Ignacio Rodriguez, Josep Maria Caba, Marta Carrascal, Jimenez Jose Carlos, Ernest Giralt, Ignacio Manzanares, Fernando Albericio, Miriam Royo, Angel López-Macià
Publikováno v:
Peptides: The Wave of the Future ISBN: 9789401039055
The sea is a great source of biodiversity, because life conditions there create unique mechanisms of chemical defense. Herein, the solid-phase total synthesis of Trunk-amide A [1] and Kahalalide F [2] (Figure 1), two cyclic peptides from marine origi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c74d18ee1e018b7ef9697581fcd23a72
https://doi.org/10.1007/978-94-010-0464-0_97
https://doi.org/10.1007/978-94-010-0464-0_97
