Zobrazeno 1 - 10
of 335
pro vyhledávání: '"Josep M Grinyó"'
Autor:
Alonso Narváez, Roser Guiteras, Anna Sola, Anna Manonelles, Juan Morote, Juan Torras, Josep M Grinyó, Josep M Cruzado
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215232 (2019)
BackgroundThe costimulatory CD40-CD40L pathway plays a role in kidney inflammation. We have previously reported that renal CD40 upregulation precedes cellular interstitial infiltrate and fibrosis in the unilateral ureteral obstruction (UUO) model. He
Externí odkaz:
https://doaj.org/article/f3b33dfb424e4386a4b43c0d4b2c3332
Autor:
Beatriz Fernández-Alarcón, Oscar Nolberger, Anna Vidal-Alabró, Raul Rigo-Bonnin, Josep M. Grinyó, Edoardo Melilli, Nuria Montero, Anna Manonelles, Ana Coloma, Alex Favà, Sergi Codina, Josep M. Cruzado, Helena Colom, Nuria Lloberas
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
AimsThe once-daily extended-release tacrolimus formulation (ER-Tac) has demonstrated similar efficacy and safety to the twice-daily immediate-release formulation (IR-Tac), but few population-based pharmacokinetic models have been developed in de novo
Externí odkaz:
https://doaj.org/article/e1e7a764787d4907916c5088a819c282
Autor:
Ines Rama, Ines Llaudó, Pere Fontova, Gema Cerezo, Carlos Soto, Casimiro Javierre, Miguel Hueso, Nuria Montero, Alberto Martínez-Castelao, Juan Torras, Josep M Grinyó, Josep M Cruzado, Nuria Lloberas
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164969 (2016)
Patients undergoing conventional hemodialysis (C-HD) present a greater immuno-inflammatory state probably related to uremia, sympathetic nervous system (SNS) activation and /or membrane bioincompatibility, which could improve with a technique-switchi
Externí odkaz:
https://doaj.org/article/9e69733e077c47f0b182c2c9a1d8f6e3
Autor:
Anna Vidal-Alabró, Helena Colom, Pere Fontova, Gema Cerezo, Edoardo Melilli, Nuria Montero, Ana Coloma, Anna Manonelles, Alex Favà, Josep M. Cruzado, Joan Torras, Josep M. Grinyó, Nuria Lloberas
Publikováno v:
Nefrología (English Edition), Vol 44, Iss 2, Pp 204-216 (2024)
Background and justification: The strategy of the concentration-dose (C/D) approach and the different profiles of tacrolimus (Tac) according to the cytochrome P450 polymorphisms (CYPs) focus on the metabolism of Tac and are proposed as tools for the
Externí odkaz:
https://doaj.org/article/080bb41af9964a478495db2667e29f1c
Autor:
Anna Vidal-Alabró, Helena Colom, Pere Fontova, Gema Cerezo, Edoardo Melilli, Núria Montero, Ana Coloma, Anna Manonellas, Alexandre Favà, Josep M. Cruzado, Joan Torras, Josep M. Grinyó, Núria Lloberas
Publikováno v:
Nefrología, Vol 44, Iss 2, Pp 204-216 (2024)
Resumen: Antecedentes y justificación: La estrategia de la aproximación concentración-dosis (C/D) y los distintos perfiles del tacrolimus (Tac), según los polimorfismos del citocromo P450 (CYPs) se centran en el metabolismo de Tac y se plantean c
Externí odkaz:
https://doaj.org/article/05d6c0eae98441bc9adb797370fdde68
Autor:
Elena Crespo, Marc Lucia, Josep M Cruzado, Sergio Luque, Edoardo Melilli, Anna Manonelles, Nuria Lloberas, Joan Torras, Josep M Grinyó, Oriol Bestard
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117618 (2015)
Preformed T-cell immune-sensitization should most likely impact allograft outcome during the initial period after kidney transplantation, since donor-specific memory T-cells may rapidly recognize alloantigens and activate the effector immune response
Externí odkaz:
https://doaj.org/article/27d01757638645c5a419df5994dd4a55
Autor:
Èlia Ripoll, Ana Merino, Immaculada Herrero-Fresneda, Josep M Aran, Montse Goma, Nuria Bolaños, Laura de Ramon, Oriol Bestard, Josep M Cruzado, Josep M Grinyó, Juan Torras
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65068 (2013)
Lupus nephritis (LN) is an autoimmune disorder in which co-stimulatory signals have been involved. Here we tested a cholesterol-conjugated-anti-CD40-siRNA in dendritic cells (DC) in vitro and in a model of LPS to check its potency and tissue distribu
Externí odkaz:
https://doaj.org/article/ddac516d3318448f99213346262285bd
Publikováno v:
Frontiers in Immunology, Vol 3 (2012)
The research on T cell immunosuppression therapies has attracted most of the attention in clinical transplantation. However, B cells and humoral immune responses are increasingly acknowledged as crucial mediators of chronic allograft rejection. Indee
Externí odkaz:
https://doaj.org/article/01a17a9bf1404ceea61ef2ef8f3fba19
Autor:
Gemma Chiva-Blanch, Pepita Giménez-Bonafe, Inés Llaudó, Joan Torras, Josep M Cruzado, Jordi Pétriz, Esther Castaño, Marcella Franquesa, Avelina Tortosa, Immaculada Herrero-Fresneda, Inés Rama, Oriol Bestard, Josep M Grinyó, Núria LLoberas
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 12, Iss 3 (2009)
P-glycoprotein (Pgp), a protein codified by Multi Drug Resistance (MDR1) gene, has a detoxifying function and might influence the toxicity and pharmacokinetics and pharmacodynamics of drugs. Sampling strategies to improve Pgp studies could be useful
Externí odkaz:
https://doaj.org/article/afae8c450f834c4486e8a98ebffeb3af
Autor:
Zeyar Mohammed Ali, Marinda Meertens, Beatriz Fernández, Pere Fontova, Anna Vidal-Alabró, Raul Rigo-Bonnin, Edoardo Melilli, Josep M. Cruzado, Josep M. Grinyó, Helena Colom, Nuria Lloberas
Publikováno v:
Pharmaceutics, Vol 15, Iss 12, p 2699 (2023)
The aim of the study is to develop a population pharmacokinetic (PopPK) model and to investigate the influence of CYP3A5/CYP3A4 and ABCB1 single nucleotide polymorphisms (SNPs) on the Tacrolimus PK parameters after LCP-Tac formulation in stable adult
Externí odkaz:
https://doaj.org/article/9d949f15b70a4ab1b8f23ab50ab7990f