MMPBSA Decomposition of the Binding Energy throughout a Molecular Dynamics Simulation of Amyloid-Beta (Aß10−35) Aggregation

Autor: Josep M. Campanera, Ramon Pouplana

Publikováno v: Molecules, Vol 15, Iss 4, Pp 2730-2748 (2010)

Recent experiments with amyloid-beta (Aβ) peptides indicate that the formation of toxic oligomers may be an important contribution to the onset of Alzheimer’s disease. The toxicity of Aβ oligomers depend on their structure, which is governed by a

Externí odkaz: https://doaj.org/article/42e45f8fbb054409afb717ecdb8b095a

Tetrameric Aβ40 and Aβ42 β-Barrel Structures by Extensive Atomistic Simulations. II. In Aqueous Solution

Autor: Phuong H. Nguyen, Son Tung Ngo, Josep M. Campanera, Antoine Loquet, Philippe Derreumaux

Publikováno v: Journal of the Chemical Society B: Physical Organic Journal of the Chemical Society B: Physical Organic
Journal of the Chemical Society B: Physical Organic Journal of the Chemical Society B: Physical Organic, Royal Society of Chemistry, 2019, 123 (17), pp.3643-3648
Journal of Physical Chemistry B
Journal of Physical Chemistry B, American Chemical Society, 2019, 123 (31), pp.6750-6756. ⟨10.1021/acs.jpcb.9b05288⟩

Alzheimer's disease (AD) is characterized by the accumulation of extracellular Aβ42 and Aβ40 oligomers and plaques. In a recent computational study, we found that the presence of the residues I41 and A42 increases significantly the propensity of A�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a26fc8e06dc56d0af4c2669d84a82d1e
https://hal.archives-ouvertes.fr/hal-03181379

Synthesis and biological properties of aryl methyl sulfones

Autor: Núria Boixareu, Gloria Rosell, M. Dolors Pujol, Lorena Navarro, Klaus Pors, Silvia Sánchez, Josep M. Campanera, Ramon Pouplana

Publikováno v: Bioorganicmedicinal chemistry. 26(14)

A novel group of aryl methyl sulfones based on nonsteroidal anti-inflammatory compounds exhibiting a methyl sulfone instead of the acetic or propionic acid group was designed, synthesized and evaluated in vitro for inhibition against the human cycloo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::601443743d17aa48d8e118ca2308dada
https://pubmed.ncbi.nlm.nih.gov/29980364

Modulating the person–environment relationship through local government intervention in England

Autor: Paul Higgins, Alexandre Nobajas, Josep M. Campanera

Publikováno v: Applied Geography. 47:20-32

Understanding the impact of local authority intervention on the person–environment relationship is critical for a policy objective that aims to enhance citizen well-being. Although private wealth may protect individuals and families from the harshe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd4e2409534658dba44946e764e234c4
https://doi.org/10.1016/j.apgeog.2013.12.001

The Relationship Between Residential Quality of Life and Socioeconomic Status in England

Autor: Paul Higgins, Alexandre Nobajas, Josep M. Campanera

Publikováno v: Urban Affairs Review. 50:100-133

This article explores the quintessential “person–environment” relationship that forms the core of the subdiscipline of social geography within the context of a national accountability shift from state to society in England. Two Audit Commission

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c801d45124c0aa8442ee8dfb4d27755
https://doi.org/10.1177/1078087413485204