Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Joselin M Vargas"'
Autor:
A. Rouf Banday, Olusegun O. Onabajo, Seraph Han-Yin Lin, Adeola Obajemu, Joselin M. Vargas, Krista A. Delviks-Frankenberry, Philippe Lamy, Ariunaa Bayanjargal, Clara Zettelmeyer, Oscar Florez-Vargas, Vinay K. Pathak, Lars Dyrskjøt, Ludmila Prokunina-Olsson
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
A. Rouf Banday et al. report targeting alternative splicing of APOBEC3B as a strategy to modulate APOBEC-mediated mutagenesis in cancers. Higher expression of the mutagenic APOBEC3B isoform predicted shorter progression-free survival in bladder cance
Externí odkaz:
https://doaj.org/article/c4fee0bc579f4d40a8783a55e109bac9
Autor:
Olusegun O. Onabajo, Fang Wang, Mei-Hsuan Lee, Oscar Florez-Vargas, Adeola Obajemu, Chizu Tanikawa, Joselin M. Vargas, Shu-Fen Liao, Ci Song, Yu-Han Huang, Chen-Yang Shen, A. Rouf Banday, Thomas R. O’Brien, Zhibin Hu, Koichi Matsuda, Ludmila Prokunina-Olsson
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
IFNL3/IFNL4 polymorphisms are inversely associated with the risk of chronic hepatitis C virus (HCV) infection and cirrhosis, two major risk factors for developing hepatocellular carcinoma (HCC). To further explore these inverse associations and their
Externí odkaz:
https://doaj.org/article/f0459e7d568f4786a7c64dbc64a7683f
Autor:
A. Rouf Banday, Megan L. Stanifer, Oscar Florez-Vargas, Olusegun O. Onabajo, Brenen W. Papenberg, Muhammad A. Zahoor, Lisa Mirabello, Timothy J. Ring, Chia-Han Lee, Paul S. Albert, Evangelos Andreakos, Evgeny Arons, Greg Barsh, Leslie G. Biesecker, David L. Boyle, Mark S. Brahier, Andrea Burnett-Hartman, Mary Carrington, Euijin Chang, Pyoeng Gyun Choe, Rex L. Chisholm, Leandro M. Colli, Clifton L. Dalgard, Carolynn M. Dude, Jeff Edberg, Nathan Erdmann, Heather S. Feigelson, Benedito A. Fonseca, Gary S. Firestein, Adam J. Gehring, Cuncai Guo, Michelle Ho, Steven Holland, Amy A. Hutchinson, Hogune Im, Les’Shon Irby, Michael G. Ison, Naima T. Joseph, Hong Bin Kim, Robert J. Kreitman, Bruce R. Korf, Steven M. Lipkin, Siham M. Mahgoub, Iman Mohammed, Guilherme L. Paschoalini, Jennifer A. Pacheco, Michael J. Peluso, Daniel J. Rader, David T. Redden, Marylyn D. Ritchie, Brooke Rosenblum, M. Elizabeth Ross, Hanaisa P. Sant Anna, Sharon A. Savage, Sudha Sharma, Eleni Siouti, Alicia K. Smith, Vasiliki Triantafyllia, Joselin M. Vargas, Jose D. Vargas, Anurag Verma, Vibha Vij, Duane R. Wesemann, Meredith Yeager, Xu Yu, Yu Zhang, Steeve Boulant, Stephen J. Chanock, Jordan J. Feld, Ludmila Prokunina-Olsson
Publikováno v:
Nature Genetics. 54:1103-1116
The chr12q24.13 locus encoding OAS1–OAS3 antiviral proteins has been associated with coronavirus disease 2019 (COVID-19) susceptibility. Here, we report genetic, functional and clinical insights into this locus in relation to COVID-19 severity. In
Autor:
Krista A. Delviks-Frankenberry, Olusegun O. Onabajo, Seraph Han-Yin Lin, Vinay K. Pathak, Ariunaa Bayanjargal, Oscar Florez-Vargas, Joselin M. Vargas, Clara Zettelmeyer, Philippe Lamy, Lars Dyrskjøt, A. Rouf Banday, Adeola Obajemu, Ludmila Prokunina-Olsson
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Communications Biology
Rouf Banday, A, Onabajo, O O, Lin, S H Y, Obajemu, A, Vargas, J M, Delviks-Frankenberry, K A, Lamy, P, Bayanjargal, A, Zettelmeyer, C, Florez-Vargas, O, Pathak, V K, Dyrskjøt, L & Prokunina-Olsson, L 2021, ' Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity ', Communications Biology, vol. 4, no. 1, 386 . https://doi.org/10.1038/s42003-021-01844-5
Communications Biology
Rouf Banday, A, Onabajo, O O, Lin, S H Y, Obajemu, A, Vargas, J M, Delviks-Frankenberry, K A, Lamy, P, Bayanjargal, A, Zettelmeyer, C, Florez-Vargas, O, Pathak, V K, Dyrskjøt, L & Prokunina-Olsson, L 2021, ' Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity ', Communications Biology, vol. 4, no. 1, 386 . https://doi.org/10.1038/s42003-021-01844-5
APOBEC3A (A3A) and APOBEC3B (A3B) enzymes drive APOBEC-mediated mutagenesis. Identification of factors affecting the activity of these enzymes could help modulate mutagenesis and associated clinical outcomes. Here, we show that canonical and alternat
Autor:
Jordan J. Feld, Pyoeng Gyun Choe, Rex L Chrisholm, Joselin M Vargas, Vibha Vij, Nathan Erdmann, Mary Carrington, A Rouf Banday, Sharon A. Savage, Michael G. Ison, Duane R. Wesemann, Anurag Verma, Leslie G. Biesecker, Euijin Chang, Chia-Han Lee, Gary S. Firestein, Adam J. Gehring, Lisa Mirabello, Robert J. Kreitman, Timothy J Ring, Michael J Peluso, Bruce R. Korf, Hogune Im, Yu Zhang, Daniel J. Rader, Megan L. Stanifer, Marylyn D. Ritchie, Jennifer A. Pacheco, Muhammad Atif Zahoor, Hanaisa P Sant Anna, Greg Barsh, Steeve Boulant, Meredith Yeager, Brooke Rosenbloom, Ludmila Prokunina-Olsson, David T. Redden, David L. Boyle, Olusegun O Onabajo, Evangelos Andreakos, Michelle Ho, Oscar Florez-Vargas, Heather Spencer Feigelson, Eleni Siouti, Amy Hutchinson, Xu G. Yu, Vasiliki Triantafyllia, Brenen W Papenberg, Andrea N. Burnett-Hartman, Jeffrey C. Edberg, Clifton L. Dalgard, Steven M. Holland, Evgeny Arons, Stephen J. Chanock, Hong Bin Kim
Publikováno v:
medRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Genomic regions have been associated with COVID-19 susceptibility and outcomes, including the chr12q24.13 locus encoding antiviral proteins OAS1-3. Here, we report genetic, functional, and clinical insights into genetic associations within this locus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dec1a13dc7d8e808d3b9532e357ddc3
https://doi.org/10.1101/2021.07.09.21260221
https://doi.org/10.1101/2021.07.09.21260221
Autor:
Chen-Yang Shen, Yu Han Huang, Joselin M. Vargas, A. Gordon Robertson, Fang Wang, Mei Hsuan Lee, Ci Song, Chizu Tanikawa, A. Rouf Banday, Koichi Matsuda, Mauro A. A. Castro, Adeola Obajemu, Zhibin Hu, Ludmila Prokunina-Olsson, Shu Fen Liao, Oscar Florez-Vargas, Thomas R. O'Brien, Olusegun O. Onabajo
Chronic hepatitis C virus (HCV) infection and cirrhosis are major risk factors for developing hepatocellular carcinoma (HCC). Genetic polymorphisms in theIFNL3/IFNL4locus have been associated both with impaired clearance of HCV and protection from li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db572c1f61bfeca4d2695fca80ec7e41
https://doi.org/10.1101/2020.10.28.359398
https://doi.org/10.1101/2020.10.28.359398
Autor:
Patricio Doldan, Steeve Boulant, Ludmila Prokunina-Olsson, Megan L. Stanifer, Oscar Florez-Vargas, Wusheng Yan, Joselin M. Vargas, Olusegun O. Onabajo, Juan L. Mendoza, Carmon Kee, Timothy J. Ring, A. Rouf Banday, D. Lorne Tyrrell, Helen Piontkivska, Deanna M. Santer, Adeola Obajemu
Publikováno v:
Nature Genetics
Nat Genet
bioRxiv
Nat Genet
bioRxiv
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which causes COVID-19, utilizes angiotensin-converting enzyme 2 (ACE2) for entry into target cells. ACE2 has been proposed as an interferon-stimulated gene (ISG). Thus, interferon-induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87cfd2495bb6510a87dc3ace08ee92a2
https://doi.org/10.1101/2020.07.19.210955
https://doi.org/10.1101/2020.07.19.210955
Autor:
Ludmila Prokunina-Olsson, Nina Rao, Faruk Sheikh, Joselin M. Vargas, Eric G. Meissner, Kari A. Dilley, Adeola Obajemu, Reed S. Shabman, Raymond P. Donnelly, Olusegun O. Onabajo
Publikováno v:
The Journal of Immunology. 199:3808-3820
Type III IFNs are important mediators of antiviral immunity. IFN-λ4 is a unique type III IFN because it is produced only in individuals who carry a dG allele of a genetic variant rs368234815-dG/TT. Counterintuitively, those individuals who can produ
Autor:
Joseph F. LaComb, Gerardo G. Mackenzie, Joselin M. Vargas, Brandon M. Vaeth, Ruixue Wang, Francis Johnson, Lorne M. Golub, Matthew G Digiovanni, Swaroopa Thomas, Matthew D. Nemesure, Naveen Mallangada, Jennie L. Williams
Publikováno v:
Molecular carcinogenesis. 57(9)
Pancreatic Cancer (PC) is a deadly disease in need of new therapeutic options. We recently developed a novel tricarbonylmethane agent (CMC2.24) as a therapeutic agent for PC, and evaluated its efficacy in preclinical models of PC. CMC2.24 inhibited t