Brain-to-gut trafficking of alpha-synuclein by CD11c+ cells in a mouse model of Parkinson’s disease

Autor: Rhonda L. McFleder, Anastasiia Makhotkina, Janos Groh, Ursula Keber, Fabian Imdahl, Josefina Peña Mosca, Alina Peteranderl, Jingjing Wu, Sawako Tabuchi, Jan Hoffmann, Ann-Kathrin Karl, Axel Pagenstecher, Jörg Vogel, Andreas Beilhack, James B. Koprich, Jonathan M. Brotchie, Antoine-Emmanuel Saliba, Jens Volkmann, Chi Wang Ip

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Abstract Inflammation in the brain and gut is a critical component of several neurological diseases, such as Parkinson’s disease (PD). One trigger of the immune system in PD is aggregation of the pre-synaptic protein, α-synuclein (αSyn). Understa

Externí odkaz: https://doaj.org/article/64b3f60bf6a74cc880822e0307d481d0

Fibroblastic reticular cells mitigate acute GvHD via MHCII-dependent maintenance of regulatory T cells

Autor: Haroon Shaikh, Joern Pezoldt, Zeinab Mokhtari, Juan Gamboa Vargas, Duc-Dung Le, Josefina Peña Mosca, Estibaliz Arellano Viera, Michael A.G. Kern, Caroline Graf, Niklas Beyersdorf, Manfred B. Lutz, Angela Riedel, Maike Büttner-Herold, Alma Zernecke, Hermann Einsele, Antoine-Emmanuel Saliba, Burkhard Ludewig, Jochen Huehn, Andreas Beilhack

Publikováno v: JCI Insight, Vol 7, Iss 22 (2022)

Acute graft versus host disease (aGvHD) is a life-threatening complication of allogeneic hematopoietic cell transplantation (allo-HCT) inflicted by alloreactive T cells primed in secondary lymphoid organs (SLOs) and subsequent damage to aGvHD target

Externí odkaz: https://doaj.org/article/611e9d7a43884ebd9ad1480c9f61f8b7

Mesenteric Lymph Node Transplantation in Mice to Study Immune Responses of the Gastrointestinal Tract

Autor: Haroon Shaikh, Juan Gamboa Vargas, Zeinab Mokhtari, Katja J. Jarick, Maria Ulbrich, Josefina Peña Mosca, Estibaliz Arellano Viera, Caroline Graf, Duc-Dung Le, Katrin G. Heinze, Maike Büttner-Herold, Andreas Rosenwald, Joern Pezoldt, Jochen Huehn, Andreas Beilhack

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Mesenteric lymph nodes (mLNs) are sentinel sites of enteral immunosurveillance and immune homeostasis. Immune cells from the gastrointestinal tract (GIT) are constantly recruited to the mLNs in steady-state and under inflammatory conditions resulting

Externí odkaz: https://doaj.org/article/1c368ca7259645cb9ee247844a60d2f9

Searching for long-lived particles beyond the Standard Model at the Large Hadron Collider

Autor: Alimena, Juliette, Beacham, James, Borsato, Martino, Cheng, Yangyang, Vidal, Xabier Cid, Cottin, Giovanna, De Roeck, Albert, Desai, Nishita, Curtin, David, Evans, Jared A., Knapen, Simon, Kraml, Sabine, Lessa, Andre, Liu, Zhen, Mehlhase, Sascha, Ramsey-Musolf, Michael J., Russell, Heather, Shelton, Jessie, Shuve, Brian, Verducci, Monica, Zurita, Jose, Adams, Todd, Adersberger, Michael, Alpigiani, Cristiano, Apresyan, Artur, Bainbridge, Robert John, Batozskaya, Varvara, Beauchesne, Hugues, Benato, Lisa, Berlendis, S., Bhal, Eshwen, Blekman, Freya, Borovilou, Christina, Boyd, Jamie, Brau, Benjamin P., Bryngemark, Lene, Buchmueller, Oliver, Buschmann, Malte, Buttinger, William, Campanelli, Mario, Cesarotti, Cari, Chen, Chunhui, Cheng, Hsin-Chia, Cheong, Sanha, Citron, Matthew, Coccaro, Andrea, Coco, V., Conte, Eric, Cormier, Félix, Corpe, Louie D., Craig, Nathaniel, Cui, Yanou, Dall'Occo, Elena, Dallapiccola, C., Darwish, M. R., Davoli, Alessandro, de Cosa, Annapaola, De Simone, Andrea, Rose, Luigi Delle, Deppisch, Frank F., Dey, Biplab, Diamond, Miriam D., Dienes, Keith R., Dildick, Sven, Döbrich, Babette, Drewes, Marco, Eich, Melanie, ElSawy, M., del Valle, Alberto Escalante, Facini, Gabriel, Farina, Marco, Feng, Jonathan L., Fischer, Oliver, Flaecher, H. U., Foldenauer, Patrick, Freytsis, Marat, Fuks, Benjamin, Galon, Iftah, Gershtein, Yuri, Giagu, Stefano, Giammanco, Andrea, Gligorov, Vladimir V., Golling, Tobias, Grancagnolo, Sergio, Gustavino, Giuliano, Haas, Andrew, Hahn, Kristian, Hajer, Jan, Hammad, Ahmed, Heinrich, Lukas, Heisig, Jan, Helo, J. C., Hesketh, Gavin, Hill, Christopher S., Hirsch, Martin, Hohlmann, M., Hulsbergen, W., Huth, John, Ilten, Philip, Jacques, Thomas, Jayatilaka, Bodhitha, Jeng, Geng-Yuan, Johns, K. A., Kaji, Toshiaki, Kasieczka, Gregor, Kats, Yevgeny, Kazana, Malgorzata, Keller, Henning, Khlopov, Maxim Yu., Kling, Felix, Kolberg, Ted R., Kostiuk, Igor, Kuwertz, Emma Sian, Kvam, Audrey, Landsberg, Greg, Lanfranchi, Gaia, Lara, Iñaki, Ledovskoy, Alexander, Linthorne, Dylan, Liu, Jia, Longarini, Iacopo, Lowette, Steven, Lubatti, Henry, Lutz, Margaret, Luo, Jingyu, Mamužić, Judita, Marinangeli, Matthieu, Mariotti, Alberto, Marlow, Daniel, McCullough, Matthew, McDermott, Kevin, Mermod, P., Milstead, David, Mitsou, Vasiliki A., Berlingen, Javier Montejo, Moortgat, Filip, Morandini, Alessandro, Morris, Alice Polyxeni, Morse, David Michael, Mrenna, Stephen, Nachman, Benjamin, Nemevšek, Miha, Nesti, Fabrizio, Ohm, Christian, Pascoli, Silvia, Pedro, Kevin, Peña, Cristián, Rodriguez, Karla Josefina Pena, Piedra, Jónatan, Pinfold, James L., Policicchio, Antonio, Popara, Goran, Prisciandaro, Jessica, Proffitt, Mason, Rauco, Giorgia, Redi, Federico, Reece, Matthew, Hall, Allison Reinsvold, Sfar, H. Rejeb, Renner, Sophie, Roepe, Amber, Ronzani, Manfredi, Salvioni, Ennio, Santra, Arka, Sawada, Ryu, Scholtz, Jakub, Schuster, Philip, Schwaller, Pedro, Sebastiani, Cristiano, Sekmen, Sezen, Selvaggi, Michele, Si, Weinan, Soffi, Livia, Stolarski, Daniel, Stuart, David, Stupak III, John, Sung, Kevin, Taylor, Wendy, Templ, Sebastian, Thomas, Brooks, Torró-Pastor, Emma, Trocino, Daniele, Trojanowski, Sebastian, Trovato, Marco, Tsai, Yuhsin, Tully, C. G., Vámi, Tamás Álmos, Vasquez, Juan Carlos, Sierra, Carlos Vázquez, Vellidis, K., Vermassen, Basile, Vit, Martina, Walker, Devin G. E., Wang, Xiao-Ping, Watts, Gordon, Xie, Si, Yexley, Melissa, Young, Charles, Yu, Jiang-Hao, Zalewski, Piotr, Zhang, Yongchao

Publikováno v: J. Phys. G: Nucl. Part. Phys. 47 090501 (2020)

Particles beyond the Standard Model (SM) can generically have lifetimes that are long compared to SM particles at the weak scale. When produced at experiments such as the Large Hadron Collider (LHC) at CERN, these long-lived particles (LLPs) can deca

Externí odkaz: http://arxiv.org/abs/1903.04497

A TNFR2-Specific TNF Fusion Protein With Improved In Vivo Activity.

Autor: Vargas, Juan Gamboa, Wagner, Jennifer, Shaikh, Haroon, Lang, Isabell, Medler, Juliane, Anany, Mohamed, Steinfatt, Tim, Mosca, Josefina Peña, Haack, Stephanie, Dahlhoff, Julia, Büttner-Herold, Maike, Graf, Carolin, Viera, Estibaliz Arellano, Einsele, Hermann, Wajant, Harald, Beilhack, Andreas

Publikováno v: Frontiers in Immunology; 2024, p1-13, 13p