Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Josefa Hofmann"'
Autor:
Hannelore Rampp, Markus R. Heinrich, Xiangyu Liu, Katrin Eitel, Inbar Fish, Peter Gmeiner, Sandra G. Vincent, Roger K. Sunahara, Ashutosh Banerjee, Hongtao Liu, Harald Hübner, Josefa Hofmann, Mary J. Clark, Brian K. Kobilka, Kunio Hirata, Amelie L. Bartuschat, John T. Fisher, Brian K. Shoichet, Jonas Kaindl, Benjamin Schaake
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 47
Liu, Hongtao; Hofmann, Josefa; Fish, Inbar; Schaake, Benjamin; Eitel, Katrin; Bartuschat, Amelie; et al.(2018). Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 115(47), 12046-12050. doi: 10.1073/pnas.1813988115. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/7dq0974t
Proceedings of the National Academy of Sciences of the United States of America
Liu, Hongtao; Hofmann, Josefa; Fish, Inbar; Schaake, Benjamin; Eitel, Katrin; Bartuschat, Amelie; et al.(2018). Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 115(47), 12046-12050. doi: 10.1073/pnas.1813988115. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/7dq0974t
Proceedings of the National Academy of Sciences of the United States of America
Significance The development of selective antagonists for muscarinic acetylcholine receptors is challenging due to high homology in orthosteric binding sites among subtypes. Starting from a single amino acid difference in the orthosteric pockets in M
Autor:
Oliver Fischer, Markus R. Heinrich, Josefa Hofmann, Martin F. Fromm, Hannelore Rampp, Gerald Pratsch, Peter Gmeiner, Regina Verena Taudte, Harald Hübner, Amelie L. Bartuschat, Jonas Kaindl
Publikováno v:
Journal of medicinal chemistry. 63(8)
Muscarinic M3 receptor antagonists and inverse agonists displaying high affinity and subtype selectivity over the antitarget M2 are valuable pharmacological tools and may enable improved treatment of chronic obstructive pulmonary disease (COPD), asth
Publikováno v:
Chemistry – A European Journal. 23:9647-9656
The radical arylation of anilines and pyrroles can be achieved under transition-metal- and catalyst-free conditions by using aryldiazotates in strongly alkaline aqueous solutions. The aryldiazotates act as protected diazonium ions, which do not under
Autor:
Josefa Hofmann, Markus R. Heinrich
Publikováno v:
Tetrahedron Letters. 57:4334-4340
This short review gives an overview over recent developments in the field of intermolecular radical arylations of arenes and heteroarenes. Transformations of this type are formally comparable to C–H activation reactions and more simple starting mat
Publikováno v:
The Journal of Organic Chemistry. 79:2314-2320
Substituted 2-aminobiphenyls have been prepared from arylhydrazine hydrochlorides and anilines in biphasic radical arylation reactions with dioxygen from air as a most simple and readily available oxidant. Under optimized conditions, the free amino f
Autor:
Josefa Hofmann, Markus R. Heinrich
Publikováno v:
ChemInform. 47
This short review gives an overview over recent developments in the field of intermolecular radical arylations of arenes and heteroarenes. Transformations of this type are formally comparable to C–H activation reactions and more simple starting mat
Publikováno v:
The Journal of organic chemistry. 81(20)
Although general interest in radical arylation reactions has grown rapidly in recent years, poor regioselectivities and the need to use a large excess of the radical-accepting arene have hindered their application to substituted benzenes. We now desc
Publikováno v:
ChemInform. 45
Substituted 2-aminobiphenyls have been prepared from arylhydrazine hydrochlorides and anilines in biphasic radical arylation reactions with dioxygen from air as a most simple and readily available oxidant. Under optimized conditions, the free amino f