Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Josefa Fernandez-Álvarez"'
Publikováno v:
Journal of Clinical Immunology. 23:107-118
A human B cell clone, EBV-MB91, producing IgMλ islet cell autoantibody (ICA), obtained by Epstein–Barr virus (EBV) transformation of peripheral CD5− surface Ig+ B cells from a Type 1 diabetic child, and an EBV-MB91-derived hetrohybridoma, HY-MB9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8fd0e1bbe357f0b48e69f07b0a8b3b0
https://doi.org/10.1023/a:1022524811479
https://doi.org/10.1023/a:1022524811479
Autor:
Roger R. Gomis, E F Usac, J. Barceló, Nuria Somoza, Teresa Gallart, Odette Viñas, A. Muñoz, Josefa Fernandez-Álvarez
Publikováno v:
Diabetologia. 38:62-72
Although CD5 + B lymphocytes are mostly committed to the production of polyreactive natural autoantibodies, CD5 + B lymphocytes committed to the production of somatically mutated and monoreactive high-affinity IgM autoantibodies have been also shown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c42245cf2474b8200e8a0eaa2a96a2
https://doi.org/10.1007/bf02369354
https://doi.org/10.1007/bf02369354
Autor:
Guerson Benarroch, Ramon Gomis, Cristian Goity, Josefa Fernandez-Álvarez, Laureano Fernández-Cruz, J. Mendola, Alex Saenz
Publikováno v:
Transplantation. 57:725-730
We studied the revascularization process of isogeneic islets grafted into the kidney subcapsular space of streptozotocin-induced diabetic and nondiabetic rats by a double-labeling, indirect immunofluorescence technique using a rabbit antiserum to hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ede19784cfb179badcdf22cd820f54a
https://doi.org/10.1097/00007890-199403150-00015
https://doi.org/10.1097/00007890-199403150-00015
Autor:
Joan J. Guinovart, Maria Muñoz, Albert Barberà, Josefa Fernandez-Álvarez, Jorge Domínguez, Ramon Gomis
Publikováno v:
Diabetes. 50(1)
Tungstate was orally administered to 7.5-week-old male Zucker diabetic fatty (ZDF) rats that already showed moderate hyperglycemia (180 +/- 16 mg/dl). The animals became normoglycemic for approximately 10 days. Then, glycemia started to rise again, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b702c67412fbdf2925e5012d9f788b39
https://pubmed.ncbi.nlm.nih.gov/11147778
https://pubmed.ncbi.nlm.nih.gov/11147778
Autor:
Josefa Fernandez-Álvarez, Michela Novelli, Ramon Gomis, Marta E Fabregat, Pellegrino Masiello
In a new experimental type 2 diabetic syndrome, a 40% reduction of pancreatic beta cells was observed by morphometric analysis. In diabetic islets, as compared to control islets, insulin release was decreased in response to high glucose but not to ot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905888bf059d55eaa550934f7e0ccd2e
http://hdl.handle.net/11568/177211
http://hdl.handle.net/11568/177211
Publikováno v:
Biochemical and biophysical research communications. 248(1)
In the present study we investigate whether glucose concentration could have an effect on proinsulin biosynthesis and processing. We cultured control human islets under chronic high and low glucose concentrations. After the culture period, islets wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e88669cce24ae8d17a158d131be90f95
https://pubmed.ncbi.nlm.nih.gov/9675108
https://pubmed.ncbi.nlm.nih.gov/9675108
Autor:
Josefa Fernandez-Álvarez, Carmen Zamorano Benito, Willy Malaisse, Marta E Fabregat, Anna Novials, Teresa Gallart, Ramon Gomis
Publikováno v:
Biochemical and molecular medicine. 59(2)
The mitochondrial enzyme glycerophosphate dehydrogenase (mGDH) plays an essential role in the B-cell glucose-sensing device and its activity in islet homogenates is impaired in several animal models of type 2 diabetes. We have now developed a polyclo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e3fafdd86e16916b0b99654d517f0d
https://pubmed.ncbi.nlm.nih.gov/8986643
https://pubmed.ncbi.nlm.nih.gov/8986643
Publikováno v:
The international journal of biochemistrycell biology. 28(10)
The activities of hexokinase and glucokinase were measured in cross-linked and permeabilized rat pancreatic islets. After exposure to dimethyl suberimidate (20 mM) and digitonin (0.4 mM), the activity of hexokinase represented about half of that foun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a25a8c734eaedec029a6a218f9483c4
https://pubmed.ncbi.nlm.nih.gov/8930135
https://pubmed.ncbi.nlm.nih.gov/8930135
Autor:
Joan Rodés, Jaume Bosch, Mercedes Fernandez, Roser Casamitjana, Pilar Pizcueta, Josefa Fernandez-Álvarez, Ramon Gomis
Publikováno v:
Europe PubMed Central
Increased circulating insulin and glucagon levels are a common observation in patients with cirrhosis, as well as in portal hypertensive models. Hyperinsulinemia and hyperglucagonemia may be caused either by increased beta- and alpha-cell secretion o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c87b9fe69712268033bee5a2886ee4a
https://pubmed.ncbi.nlm.nih.gov/8175150
https://pubmed.ncbi.nlm.nih.gov/8175150
Autor:
Ramon Gomis, Josefa Fernandez-Álvarez, Abdullah Sener, Willy Malaisse, Joanne Rasschaert, Ignacio Conget
Publikováno v:
Diabetologia. 37(2)
Islets were isolated by automatic digestion from non-diabetic cadaveric organ donors and from Type 2 (non-insulin-dependent) diabetic subjects. The activity of FAD-glycerophosphate dehydrogenase, but not that of either glutamate dehydrogenase, glutam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b4862cff181682b17c149b5a3f66bee
https://pubmed.ncbi.nlm.nih.gov/8163052
https://pubmed.ncbi.nlm.nih.gov/8163052