Výsledky vyhledávání - "Josef V. Silha"

Ethnicity, Insulin Resistance, and Inflammatory Adipokines in Women at High and Low Risk for Vascular Disease

Autor: William D. Leslie, Liam J. Murphy, B. L. Grégoire Nyomba, Josef V. Silha

Publikováno v: Diabetes Care. 30:286-291

OBJECTIVE—We sought to compare the relationship between body composition, insulin resistance, and inflammatory adipokines in Aboriginal Canadian women, who are at high risk of vascular disease, with white women. RESEARCH DESIGN AND METHODS—A subg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455d4e19e1965a41fd607bf4f010efb3
https://doi.org/10.2337/dc06-1073

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Insulin-Like Growth Factor (IGF) Binding Protein-3 Attenuates Prostate Tumor Growth by IGF-Dependent and IGF-Independent Mechanisms

Autor: Josef V. Silha, Liam J. Murphy, Patricia C. Sheppard, Suresh Mishra, Jacquie Schwartz, Janice G. Dodd, Yaoting Gui

Publikováno v: Endocrinology. 147:2112-2121

IGF binding protein (IGFBP)-3 inhibits cell growth and promotes apoptosis by sequestering free IGFs. In addition IGFBP-3 has IGF-independent, proapoptotic, antiproliferative effects on prostate cancer cells in vitro. Expression of the large T-antigen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba49ab93b30dbc8b4b19a7488324447
https://doi.org/10.1210/en.2005-1270

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Angiogenic factors are elevated in overweight and obese individuals

Autor: Michal Krsek, Liam J. Murphy, P. Sucharda, Josef V. Silha

Publikováno v: International Journal of Obesity. 29:1308-1314

Adipose tissue produces both vascular growth factors and inhibitors. Since obesity is associated with expansion of the capillary bed in regional adipose depots the balance between these factors may favor angiogenesis.To investigate the relationship b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4fc5b55ccaab9150a1c9effc5960b92
https://doi.org/10.1038/sj.ijo.0802987

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Overexpression of Gly56/Gly80/Gly81-Mutant Insulin-Like Growth Factor-Binding Protein-3 in Transgenic Mice

Autor: Liam J. Murphy, Suresh Mishra, Arnold Leckstrom, Josef V. Silha, Yaoting Gui, Pinchas Cohen

Publikováno v: Endocrinology. 146:1523-1531

IGF-independent effects of IGF-binding protein-3 (IGFBP-3) have been demonstrated in vitro; however, the physiological significance of these effects in vivo is unclear. We generated two transgenic (Tg) mouse strains that overexpress a human Gly56/Gly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c3cbc2cec66ee9641300d1f48e4de7
https://doi.org/10.1210/en.2004-0905

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The effects of GH replacement in adult GH-deficient patients: changes in body composition without concomitant changes in the adipokines and insulin resistance

Autor: Vaclav Hana, Jan J. Stepan, Vlasta Justova, Josef V. Silha, Liam J. Murphy, Zdena Lacinova

Publikováno v: Clinical Endocrinology. 60:442-450

Summary background Growth hormone deficiency (GHD) in adult life has been associated with increased central adiposity, decreased insulin sensitivity, dyslipidaemia and increased risk of cardiovascular disease. The effects of GH replacement on adipone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c4165626abfda4290b20aa80e9c15a
https://doi.org/10.1111/j.1365-2265.2004.02000.x

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Perturbations in adiponectin, leptin and resistin levels in acromegaly: lack of correlation with insulin resistance

Autor: Josef V. Silha, Vladimir Weiss, Michal Krsek, Josef Marek, Liam J. Murphy, Jana Jezkova, Vaclav Hana

Publikováno v: Clinical Endocrinology. 58:736-742

BACKGROUND: Insulin resistance, impaired glucose tolerance and type 2 diabetes are common in acromegalic subjects. The mechanism underlying this insulin resistance is unclear. DESIGN: We investigated the levels of the adipocytokines, resistin, adipon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5858573d6bdb80d62c5df7b42278bd5
https://doi.org/10.1046/j.1365-2265.2003.01789.x

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Minireview: Insights from Insulin-Like Growth Factor Binding Protein Transgenic Mice

Autor: Josef V. Silha, Liam J. Murphy

Publikováno v: Endocrinology. 143:3711-3714

The existence of abundant high affinity binding proteins for the IGFs, the IGF binding proteins (IGFBPs), was first demonstrated more than 40 yr ago in the very early days of somatomedin research. With the development of molecular techniques and tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26d24a7e88d3e56bb2446a0e28bed534
https://doi.org/10.1210/en.2002-220116

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Overexpression of the Acid-Labile Subunit of the IGF Ternary Complex in Transgenic Mice

Autor: Tomislav Modric, Yaoting Gui, Liam J. Murphy, Josef V. Silha, Susan K. Durham, David R. Powell, Adisak Suwanichkul

Publikováno v: Endocrinology. 142:4305-4313

The ternary complex, composed of IGF-I or IGF-II, IGF-binding protein-3, and the acid-labile subunit, is responsible for transport of the majority of the IGF-I and IGF-II present in the circulation. Acid-labile subunit is developmentally and hormonal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d702974ade30b0c60d3855c5e4e77847
https://doi.org/10.1210/endo.142.10.8427

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