Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Josef P Kapfhammer"'
Autor:
Bertrand Gonthier, Eric Koncina, Saulius Satkauskas, Martine Perraut, Guy Roussel, Dominique Aunis, Josef P Kapfhammer, Dominique Bagnard
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5099 (2009)
There is increasing evidence for a crucial role of proteases and metalloproteinases during axon growth and guidance. In this context, we recently described a functional link between the chemoattractive Sema3C and Matrix metalloproteinase 3 (MMP3). He
Externí odkaz:
https://doaj.org/article/0ac11e2ddba143aab4eea85f245dcbe9
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Spinocerebellar ataxias (SCAs) are a group of hereditary neurodegenerative diseases mostly affecting cerebellar Purkinje cells caused by a wide variety of different mutations. One subtype, SCA14, is caused by mutations of Protein Kinase C gamma (PKC
Externí odkaz:
https://doaj.org/article/b41dccbe96344fb7bca4944a894cf1fc
Autor:
Qin-Wei Wu, Josef P. Kapfhammer
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
CRISPR-Cas13 technology is rapidly evolving as it is a very specific tool for RNA editing and interference. Since there are no significant off-target effects via the Cas13-mediated method, it is a promising tool for studying gene function in differen
Externí odkaz:
https://doaj.org/article/9926ea0624504c67bad4dda48392c529
Autor:
Qin-Wei Wu, Josef P. Kapfhammer
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9169 (2022)
Spinocerebellar ataxias (SCAs) are a heterogeneous group of autosomal dominantly inherited progressive disorders with degeneration and dysfunction of the cerebellum. Although different subtypes of SCAs are classified according to the disease-associat
Externí odkaz:
https://doaj.org/article/a84de909a4bc40309e9d997c6fd8943b
Autor:
Qin-Wei Wu, Josef P. Kapfhammer
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Spinocerebellar ataxias (SCAs) are a group of hereditary neurodegenerative diseases which are caused by diverse genetic mutations in a variety of different genes. We have identified RGS8, a regulator of G-protein signaling, as one of the genes which
Externí odkaz:
https://doaj.org/article/18dc0db8bb57455f8509148e14db4cb3
Autor:
Qin-Wei Wu, Josef P. Kapfhammer
Publikováno v:
Brain Sciences, Vol 11, Iss 8, p 1054 (2021)
RNA therapies using RNA editing and interference are currently being developed for neurological diseases. The CRISPR-Cas13 system, based on bacterial enzymes, holds great promise for developing efficient tools for RNA therapies. However, neurotoxic a
Externí odkaz:
https://doaj.org/article/6ef4d53ba77d485291a87e6bc6b9a316
Autor:
Qin-Wei Wu, Josef P. Kapfhammer
Publikováno v:
Toxins, Vol 13, Iss 4, p 262 (2021)
The CRISPR-Cas13 system based on a bacterial enzyme has been explored as a powerful new method for RNA manipulation. Due to the high efficiency and specificity of RNA editing/interference achieved by this system, it is currently being developed as a
Externí odkaz:
https://doaj.org/article/a835001f926d447280fd07511703e2b1
Publikováno v:
Genes; Volume 13; Issue 8; Pages: 1417
The autosomal dominant inherited spinocerebellar ataxias (SCAs) are a group of neurodegenerative disorders characterized by cerebellar atrophy and loss of Purkinje neurons. Spinocerebellar ataxia type 14 (SCA14) is a rare variant of SCAs caused by mi
Publikováno v:
Genes. 13(8)
The autosomal dominant inherited spinocerebellar ataxias (SCAs) are a group of neurodegenerative disorders characterized by cerebellar atrophy and loss of Purkinje neurons. Spinocerebellar ataxia type 14 (SCA14) is a rare variant of SCAs caused by mi
Autor:
Jingmin Ji, Melanie L. Hassler, Etsuko Shimobayashi, Nagendher Paka, Raphael Streit, Josef P. Kapfhammer
Publikováno v:
Neurobiology of Disease, Vol 70, Iss , Pp 1-11 (2014)
Spinocerebellar ataxias (SCAs) are hereditary diseases leading to Purkinje cell degeneration and cerebellar dysfunction. Most forms of SCA are caused by expansion of CAG repeats similar to other polyglutamine disorders such as Huntington's disease. I
Externí odkaz:
https://doaj.org/article/d453de03eea741f5b5eda3cc680c1037