Influence of protein fold stability on immunogenicity and its implications for vaccine design

Autor: Sandra Scheiblhofer, Josef Laimer, Yoan Machado, Richard Weiss, Josef Thalhamer

Publikováno v: Expert Review of Vaccines, Vol 16, Iss 5, Pp 479-489 (2017)

Introduction: In modern vaccinology and immunotherapy, recombinant proteins more and more replace whole organisms to induce protective or curative immune responses. Structural stability of proteins is of crucial importance for efficient presentation

Externí odkaz: https://doaj.org/article/b988bbf21574481e8fac94f00969b618

A hybrid of two major Blomia tropicalis allergens as an allergy vaccine candidate

Autor: Emília Maria Medeiros de Andrade Belitardo, Alvaro A. Cruz, Rogério Tanan Torres, Fatima Ferreira, Elisânia Fontes Silveira, Michael Wallner, Sara Huber, Carina S. Pinheiro, Josef Laimer, Eduardo Santos da Silva, Peter Lackner, Luis G.C. Pacheco, Peter Briza, Lorenz Aglas, Neuza Maria Alcântara-Neves

Publikováno v: Clinical and Experimental Allergy

Introduction Allergen‐specific immunotherapy (AIT) represents a curative approach for treating allergies. In the tropical and subtropical regions of the world, Blomia tropicalis (Blo t 5 and Blo t 21) is the likely dominant source of indoor allerge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f849290c4f3a546b34ac1f8a64d9e9
https://doi.org/10.1111/cea.13611

In silico design of Phl p 6 variants with altered folding stability significantly impacts antigen processing, immunogenicity and immune polarization

Autor: Florian Hofer, Sara Michelini, Stefan Stubenvoll, Lisa Strasser, Isabella Anna Joubert, Weiss Richard, Jutta Horejs-Hoeck, Sandra Scheiblhofer, Petra Winter, Martin Tollinger, Christian G. Huber, Josef Laimer, Anna S. Kamenik, Johann Brandstetter, Peter Lackner, Soh Wai Tuck, Klaus R. Liedl, Valentin Dietrich, Carolin Briganser

AbstactIntroductionProtein fold stability has been proposed to represent an intrinsic feature contributing to immunogenicity and immune polarization by influencing the amount of peptide-MHC II complexes (pMHCII). Using in silico prediction, we introd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8f2c196b6cc55d5a7f1f37afb20edd
https://doi.org/10.1101/2020.02.26.967265

Rational Design, Structure–Activity Relationship, and Immunogenicity of Hypoallergenic Pru p 3 Variants

Autor: Montserrat Fernandez-Rivas, Bettina M. Jensen, Josef Laimer, Gabriele Gadermaier, Isabel Pablos, Antonio Portolés, Fatima Ferreira, Laurian Jongejan, Juan A. Asturias, Serge A. Versteeg, Lars K. Poulsen, Nikolaos G. Papadopoulos, Peter Briza, Adriano Mari, Markus Steiner, Neil M. Rigby, Angelika Hörschläger, Peter Lackner, Stephanie Pauline Eichhorn, Ronald van Ree

Publikováno v: Molecular Nutrition & Food Research
Eichhorn, S, Hörschläger, A, Steiner, M, Laimer, J, Jensen, B M, Versteeg, S A, Pablos, I, Briza, P, Jongejan, L, Rigby, N, Asturias, J A, Portolés, A, Fernandez-Rivas, M, Papadopoulos, N G, Mari, A, Poulsen, L K, Lackner, P, van Ree, R, Ferreira, F & Gadermaier, G 2019, ' Rational Design, Structure-Activity Relationship, and Immunogenicity of Hypoallergenic Pru p 3 Variants ', Molecular Nutrition & Food Research, vol. 63, no. 18, e1900336 . https://doi.org/10.1002/mnfr.201900336
Eichhorn, S, Hörschläger, A, Steiner, M, Laimer, J, Jensen, B M, Versteeg, S A, Pablos, I, Briza, P, Jongejan, L, Rigby, N, Asturias, J A, Portolés, A, Fernandez-Rivas, M, Papadopoulos, N G, Mari, A, Poulsen, L K, Lackner, P, van Ree, R, Ferreira, F & Gadermaier, G 2019, ' Rational Design, Structure–Activity Relationship, and Immunogenicity of Hypoallergenic Pru p 3 Variants ', Molecular Nutrition and Food Research . https://doi.org/10.1002/mnfr.201900336
Molecular nutrition & food research. Wiley-VCH Verlag

Scope Allergies to lipid transfer proteins involve severe adverse reactions; thus, effective and sustainable therapies are desired. Previous attempts disrupting disulfide bonds failed to maintain immunogenicity; thus, the aim is to design novel hypoa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b9a9ac0b1ad05f26ead459a26cbba7
http://europepmc.org/articles/PMC6790652

Synergistic cross-talk of hedgehog and interleukin-6 signaling drives growth of basal cell carcinoma

Autor: Christina, Sternberg, Wolfgang, Gruber, Markus, Eberl, Suzana, Tesanovic, Manuela, Stadler, Dominik P, Elmer, Michaela, Schlederer, Sandra, Grund, Simone, Roos, Florian, Wolff, Supreet, Kaur, Doris, Mangelberger, Hans, Lehrach, Hendrik, Hache, Christoph, Wierling, Josef, Laimer, Peter, Lackner, Markus, Wiederstein, Maria, Kasper, Angela, Risch, Peter, Petzelbauer, Richard, Moriggl, Lukas, Kenner, Fritz, Aberger

Publikováno v: International Journal of Cancer

Persistent activation of hedgehog (HH)/GLI signaling accounts for the development of basal cell carcinoma (BCC), a very frequent nonmelanoma skin cancer with rising incidence. Targeting HH/GLI signaling by approved pathway inhibitors can provide sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c7bdfc3a57383f0f57d1c1c1eb30ded5
https://pubmed.ncbi.nlm.nih.gov/29987839