Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Josef Köck"'
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37248 (2012)
Experimental studies on hepatitis B virus (HBV) replication are commonly done with human hepatoma cells to reflect the natural species and tissue tropism of the virus. However, HBV can also replicate, upon transfection of virus coding plasmids, in ce
Externí odkaz:
https://doaj.org/article/5ab1379add0b41229a16d790574a0be3
Autor:
Josef Köck, Christine Rösler, Jing-Jing Zhang, Hubert E Blum, Michael Nassal, Christian Thoma
Publikováno v:
PLoS Pathogens, Vol 6, Iss 9, p e1001082 (2010)
Persistence of hepatitis B virus (HBV) infection requires covalently closed circular (ccc)DNA formation and amplification, which can occur via intracellular recycling of the viral polymerase-linked relaxed circular (rc) DNA genomes present in virions
Externí odkaz:
https://doaj.org/article/314c024ff3a542359c6ccb05ec32ba6b
Publikováno v:
Comparative Immunology, Microbiology and Infectious Diseases. 34:361-368
Recently, Tupaia belangeri was used to study the full replication cycle of hepatitis B virus (HBV) in the primary hepatocyte cultures. Thus, the Tupaia model represents a suitable model to study the effects of cytokines on HBV infection. Here, Tupaia
Autor:
Hubert E. Blum, Urte Matschl, David M. Zuckerman, Xavier Rogiers, Karsten Wursthorn, Joerg M. Pollok, Maura Dandri, Martin R. Burda, Joerg Petersen, Fritz von Weizsäcker, Josef Köck, Andreas Gocht
Publikováno v:
Journal of Hepatology. 42:54-60
Background/Aims Transplantation of primary human hepatocytes and establishment of hepatitis B virus (HBV) infection in immunodeficient urokinase plasminogen activator (uPA) transgenic mice was shown. However, the availability of usable primary human
Publikováno v:
Journal of Virology. 78:13812-13818
The carboxy-terminal sequence of the hepatitis B virus (HBV) core protein constitutes a nucleic acid binding domain that is rich in arginine residues and contains three serine phosphorylation sites. While dispensable for capsid assembly, this domain
Autor:
Jürgen Löhler, Fritz von Weizsäcker, Gabriele Spindler, Christa Kuhn, Josef Köck, Petra Nusser, Kurt Reifenberg
Publikováno v:
Journal of General Virology. 83:991-996
The function of the X protein (pX) in the replication cycle of mammalian hepadnaviruses is enigmatic. Using tissue culture experiments it has been shown that the X gene product is not central to hepatitis B virus (HBV) replication and virion export.
Autor:
Jürgen Beck, Fritz von Weizsäcker, Hubert E. Blum, Stefan Wieland, Michael Nassal, Josef Köck
Publikováno v:
Hepatology. 35:209-216
Hepadnaviral replication requires the concerted action of the polymerase and core proteins to ensure selective packaging of the RNA pregenome into nucleocapsids. Virus assembly is initiated by cis-preferential binding of polymerase to the encapsidati
Publikováno v:
Hepatology. 30:308-315
Dominant negative (DN) mutants of the hepadnaviral core protein are potent inhibitors of viral replication. We have previously shown that fusion of sequences derived from the duck hepatitis B virus (DHBV) polymerase (Pol), DHBV small surface protein
Publikováno v:
Hepatology Research. 13:133-142
In the present study we investigated the epidemiology, clinical significance and molecular characteristics of hepatitis G virus (HGV) infection in Chinese patients with chronic hepatitis B, C or non-A-E. Based on the detection of HGV RNA by reverse t
Publikováno v:
Journal of Virology. 72:9116-9120
Hepadnaviruses are DNA viruses that replicate through reverse transcription of an RNA pregenome. Viral DNA synthesis takes place inside viral nucleocapsids, formed by core protein dimers. Previous studies have identified carboxy-terminal truncations