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Akademický článek

Differences in genome, transcriptome, miRNAome, and methylome in synchronous and metachronous liver metastasis of colorectal cancer

Autor: Josef Horak, Ondrej Kubecek, Anna Siskova, Katerina Honkova, Irena Chvojkova, Marketa Krupova, Monika Manethova, Sona Vodenkova, Sandra García-Mulero, Stanislav John, Filip Cecka, Ludmila Vodickova, Jiri Petera, Stanislav Filip, Veronika Vymetalkova

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

Despite distant metastases being the critical factor affecting patients’ survival, they remain poorly understood. Our study thus aimed to molecularly characterize colorectal cancer liver metastases (CRCLMs) and explore whether molecular profiles di

Externí odkaz: https://doaj.org/article/e8f2282a449d4e539c6f4ba856f3ae77

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Akademický článek

MiR-140 leads to MRE11 downregulation and ameliorates oxaliplatin treatment and therapy response in colorectal cancer patients

Autor: Josef Horak, Alexandra Dolnikova, Ozge Cumaogullari, Andrea Cumova, Nazila Navvabi, Ludmila Vodickova, Miroslav Levy, Michaela Schneiderova, Vaclav Liska, Ladislav Andera, Pavel Vodicka, Alena Opattova

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Cancer therapy failure is a fundamental challenge in cancer treatment. One of the most common reasons for therapy failure is the development of acquired resistance of cancer cells. DNA-damaging agents are frequently used in first-line chemotherapy re

Externí odkaz: https://doaj.org/article/3522c5a78afe4cca8e6b702e06abe405

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Akademický článek

Analysis of MicroRNA Expression Changes During the Course of Therapy In Rectal Cancer Patients

Autor: Klara Cervena, Vendula Novosadova, Barbara Pardini, Alessio Naccarati, Alena Opattova, Josef Horak, Sona Vodenkova, Tomas Buchler, Pavel Skrobanek, Miroslav Levy, Pavel Vodicka, Veronika Vymetalkova

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

MicroRNAs (miRNAs) regulate gene expression in a tissue-specific manner. However, little is known about the miRNA expression changes induced by the therapy in rectal cancer (RC) patients. We evaluated miRNA expression levels before and after therapy

Externí odkaz: https://doaj.org/article/0fce0d73d1a041b9ac949c865103fdbc

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Genetic Susceptibility in Understanding of Pancreatic Ductal Adenocarcinoma Risk: A Decade-Long Effort of the PANDORA Consortium

Autor: Ludmila Vodickova, Josef Horak, Pavel Vodicka

Publikováno v: Cancer Epidemiology, Biomarkers & Prevention. 31:942-948

Pancreatic cancer, a complex disease, emerges as a severe health problem worldwide and it exhibits a poor prognosis and high mortality. Risk factors associated with sporadic pancreatic cancer remain poorly understood, even less is known about disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c355ee2f2230fd404493c29bf10705f
https://doi.org/10.1158/1055-9965.epi-21-1340

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Akademický článek

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Akademický článek

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Abstract 2316: Malignant potential of colorectal adenoma based on the telomere length

Autor: Kristyna Tomasova, Michal Kroupa, Anna Siskova, Josef Horak, Ondrej Vycital, Vaclav Liska, Ludmila Vodickova, Pavel Vodicka

Publikováno v: Cancer Research. 82:2316-2316

Telomere attrition is a well-known hallmark of malignancy in cancer tissue. Our study analyzed the relative telomere length in adenomas, precursor lesions of colorectal adenocarcinoma. We investigated if the accelerated telomere length shortening occ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13d333739a630e3aa995efa9447c3816
https://doi.org/10.1158/1538-7445.am2022-2316

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Abstract 760: Concordance of DNA copy number profiles between primary and metastatic colorectal carcinoma

Autor: Michal Kroupa, Kristyna Tomasova, Katerina Saskova, Jana Drabova, Josef Horak, Ludmila Vodickova, Jachym Rosendorf, Vaclav Liska, Pavel Vodicka

Publikováno v: Cancer Research. 82:760-760

The most common form of genomic instability in sporadic colorectal cancer (CRC) is chromosomal instability, a phenotype characterized by a high frequency of DNA copy number gain (CNG) and loss (CNL). Given the fundamental role of chromosomal instabil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15d2df71923cf84c982dd7c314087c9a
https://doi.org/10.1158/1538-7445.am2022-760

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