Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Josef Hartl"'
Publikováno v:
International Journal of Computer Assisted Radiology and Surgery. 18:865-870
Purpose: The adjustment of medical devices in the operating room is currently done by the circulating nurses. As digital interfaces for the devices are not foreseeable in the near future and to incorporate legacy devices, the robotic operation of med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50720111d381e04c01039884f52b7a4a
https://doi.org/10.1007/s11548-022-02802-0
https://doi.org/10.1007/s11548-022-02802-0
Autor:
Josef Hartl, Sergej Friesen, Diethelm Johannsmann, Richard Buchner, Dariush Hinderberger, Michaela Blech, Patrick Garidel
Publikováno v:
Molecular Pharmaceutics. 19:494-507
Molecular interaction mechanisms in high-concentrated protein systems are of fundamental importance for the rational development of biopharmaceuticals such as monoclonal antibody (mAb) formulations. In such high-concentrated protein systems, the inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a4aaf11dd35511e0f816536a3fa9ebc
https://doi.org/10.1021/acs.molpharmaceut.1c00587
https://doi.org/10.1021/acs.molpharmaceut.1c00587
Autor:
Haleh H. Haeri, Jacob Blaffert, Florian A. Schöffmann, Michaela Blech, Josef Hartl, Patrick Garidel, Dariush Hinderberger
Publikováno v:
Molecules, Vol 24, Iss 14, p 2528 (2019)
Monoclonal antibodies (mAbs) are often needed and applied in high concentration solutions, >100 mg/mL. Due to close intermolecular distances between mAbs at high concentrations (~10−20 nm at 200 mg/mL), intermolecular interactions between mAbs and
Externí odkaz:
https://doaj.org/article/8d0f2cf081444ac0850acb431e7453c9
Publikováno v:
Biophysical Chemistry. 220:7-19
Liquid-liquid phase separation (LLPS) of a monoclonal antibody solution was investigated at low ionic strength in the presence of oligovalent anions, such as citrate, trimellitate, pyromellitate and mellitate. Phase separation was observed at the iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a149aa27dc7f94e9ba5f7234222679
https://doi.org/10.1016/j.bpc.2016.08.003
https://doi.org/10.1016/j.bpc.2016.08.003
Publikováno v:
Physical Chemistry Chemical Physics. 19:32698-32707
Making use of a quartz crystal microbalance (QCM), concentrated solutions of therapeutic antibodies were studied with respect to their behavior under shear excitation with frequencies in the MHz range. At high protein concentration and neutral pH, vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af6f084345214bd837d55b86c659f28e
https://doi.org/10.1039/c7cp05711c
https://doi.org/10.1039/c7cp05711c
Autor:
Michaela Blech, Dariush Hinderberger, Patrick Garidel, Florian A. Schöffmann, Haleh H. Haeri, Jacob Blaffert, Josef Hartl
Publikováno v:
Molecules
Volume 24
Issue 14
Molecules, Vol 24, Iss 14, p 2528 (2019)
Volume 24
Issue 14
Molecules, Vol 24, Iss 14, p 2528 (2019)
Monoclonal antibodies (mAbs) are often needed and applied in high concentration solutions, >
100 mg/mL. Due to close intermolecular distances between mAbs at high concentrations (~10-20 nm at 200 mg/mL), intermolecular interactions between mAb
100 mg/mL. Due to close intermolecular distances between mAbs at high concentrations (~10-20 nm at 200 mg/mL), intermolecular interactions between mAb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ea36b034eac099970577d29049719b
https://pubmed.ncbi.nlm.nih.gov/31295948
https://pubmed.ncbi.nlm.nih.gov/31295948
Autor:
Arne Langhoff, Christian Leppin, Alexander Simon Gödde, Diethelm Johannsmann, Patrick Garidel, Frederick Sebastian Meyer, Josef Hartl
Publikováno v:
Biointerphases. 15:021004
An electrochemical quartz crystal microbalance is described, which achieves a time resolution down to 100 μs. Accumulation and averaging over a few hours bring the noise down to about 30 mHz. The application examples are pH-driven viscosity changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc051b02ed8b895ee92e19de4361432
https://doi.org/10.1116/1.5140619
https://doi.org/10.1116/1.5140619
Autor:
Birgit Linhart, Arnulf Josef Hartl, Wolfgang R. Sperr, Rudolf Valenta, M. Focke, Ursula Wiedermann, Dietrich Kraft, Josef Thalhamer, Peter Valent
Publikováno v:
Clinical Experimental Allergy. 34:1525-1533
Summary Background Almost 100 million allergic patients are sensitized to the major birch pollen allergen, Bet v 1, a 17 kDa protein containing most of the IgE epitopes present in pollens of trees belonging to the Fagales order and plant-derived food
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d84f3ac2acab22c120d62b35a5bdc1e0
https://doi.org/10.1111/j.1365-2222.2004.02081.x
https://doi.org/10.1111/j.1365-2222.2004.02081.x
Autor:
Thomas L. Diepgen, Helmut Fiebig, Oliver Kuss, Josef Thalhamer, Vera Mahler, Oliver Cromwell, Rudolf Valenta, Susanne Vrtala, Arnulf Josef Hartl, Gerold Schuler, Dietrich Kraft, Roland Suck
Publikováno v:
Clinical Experimental Allergy. 34:115-122
Summary Background We have recently engineered recombinant derivatives of the major birch pollen allergen Bet v 1 (rBet v 1 fragments and trimer) with strongly reduced allergenic activity. Objective The aim of this study was the in vivo characterizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aeaad4bffb23f7a7bb2a3dbb94d5b8d
https://doi.org/10.1111/j.1365-2222.2004.01857.x
https://doi.org/10.1111/j.1365-2222.2004.01857.x
Autor:
Peter Lindinger, Scott I. Abrams, Arnulf Josef Hartl, Josef Thalhamer, Sven Mostböck, Peter Hammerl
Publikováno v:
Vaccine. 21:4285-4296
In a BALB/c mouse model, we have previously identified a ras oncogene peptide that contained both CD8 + and CD4 + T cell epitopes in a nested configuration. In this study, we developed several plasmid DNA minigene vectors encoding these determinants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc38e657e917e6ea36c0afeb0ff216a4
https://doi.org/10.1016/s0264-410x(03)00486-9
https://doi.org/10.1016/s0264-410x(03)00486-9