Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Josef G. Meingassner"'
Autor:
Brian Cox, David C. Budd, Anna King, Gareth Williams, Nicholas Duggan, Rowan Stringer, Marcus Furegati, Alfred Schmidt, Josef G. Meingassner, Kamlesh Bala, Brian Everatt, Katharine L. Turner, Jennifer Simmons, Cerys Docx, Catherine Leblanc, Gerald Dubois, Frank Kalthoff, Caroline Wilson, Lucy Barker, Karen England, Nicola Arnold, John Westwick, Edward Charles Hall, Bindi Sohal, Jennifer Willis, Heinrich Aschauer, David Andrew Sandham, Rachael Profit, Zarin Brown, Lyndon Nigel Brown, Simon J. Watson, Jodie Manini, Christoph Walker, Matthew Thomas
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:6582-6591
Optimization of a 7-azaindole-3-acetic acid CRTh2 receptor antagonist chemotype derived from high throughput screening furnished a highly selective compound NVP-QAV680 with low nM functional potency for inhibition of CRTh2 driven human eosinophil and
Autor:
Jens-Michael Jensen, Kerstin Ahrens, Thomas Schwarz, Matthias Bräutigam, Regina Fölster-Holst, Regine Gläser, Ehrhardt Proksch, Josef G. Meingassner, Anton Stütz, Jürgen Harder, Andreas Scherer
Publikováno v:
Experimental Dermatology. 20:783-788
It has been suggested that the increased rate of bacterial infection in atopic dermatitis (AD) may be caused by reduced antimicrobial protein (AMP) expression. We were interested whether common treatments in AD affect antimicrobial defense. We invest
Autor:
Michael Schunck, Ehrhardt Proksch, Graziella-Francesca Podda, Anton Stuetz, Jürgen Harder, Josef G. Meingassner, Kerstin Ahrens, Jens-Michael Schröder
Publikováno v:
Journal of Investigative Dermatology. 131(2):443-452
Protection of the skin against microbiological infection is provided by the permeability barrier and by antimicrobial proteins. We asked whether the expression of murine β-defensins (mBDs)-1, -3, and -14—orthologs of human β-defensins hBD-1, -2,
Autor:
Adelheid Elbe-Bürger, Christine Vaculik, Johnnie Akgün, Gero Kramer, Simone Meindl, Marion Prior, Georg Stingl, Anton Stuetz, Josef G. Meingassner
Publikováno v:
Journal of Investigative Dermatology. 129(9):2184-2192
Atopic dermatitis arises primarily in early infancy. In these patients, corticosteroids are used especially with great caution because of their side effects. Calcineurin inhibitors such as pimecrolimus (PIM) could be useful, but safety concerns have
Autor:
Murty A. R. C. Bulusu, Gerhard Zenke, Gerhard Schulz, Christophe Rochais, Thomas Tricotet, Andrea Steck, Peter Hiestand, Markus Bacher, Josef G. Meingassner, Trixie Wagner, Peter Waldstätten, Walter Schuler
Publikováno v:
Helvetica Chimica Acta. 92:839-889
Publikováno v:
Mycoses. 30:10-18
Summary: Two strains of A. fumigatus (δ 704 avirulent, δ 705 virulent) were tested in female NMRI-mice (20–25 g). After i.v. inoculation (2,8 × 105 spores per mouse) mice were sacrificed on day 4 and 6 (δ 705), further on day 6, 12, 14, 21, 28
Publikováno v:
Mycoses. 28:244-250
Zusammenfassung: Zur Prufung von Antimykotika auf ihre Wirkung bei Infektionen von Mansen mit Aspergillus fumigatus warden 103 Sporen in eine Niere pro Tier inokuliert. Nach einer zweitagigen Behandlungsperiode erfolgte am dritten Versuchstag die Bes
Publikováno v:
Journal of Experimental Medicine 204 (4): 735-745.
The Journal of Experimental Medicine
The Journal of Experimental Medicine
CCR7-mediated migration of naive T cells into the secondary lymphoid organs is a prerequisite for their encounter with mature dendritic cells, the productive presentation of cognate antigen, and consequent T cell proliferation and effector differenti
Autor:
Hermann Fahrngruber, Assadollah Bavandi, Frank Kalthoff, Josef G. Meingassner, Heinrich Aschauer, Boris M. Hartmann
Publikováno v:
Journal of Dermatological Science. 43:117-126
Summary Background As reported previously, oral administration of the calcineurin inhibitors (CNI) pimecrolimus and tacrolimus resulted in equipotent inhibition of the elicitation phase of contact hypersensitivity (CHS) in mice. The sensitization pha
Publikováno v:
International Archives of Allergy and Immunology. 141:199-212
Using a newly developed model of allergic contact dermatitis in pigs, calcineurin inhibitors of the tacrolimus and ascomycin type were shown to have a highly anti-inflammatory action after topical application. These findings provided the first pharma