Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Josef Fried"'
Autor:
Han-Zhong Zhang, Eva Papp, John C. Wu, Kotesvar Rao, Kenneth Straub, Stephen F. Carr, Josef Fried
Publikováno v:
Journal of Medicinal Chemistry. 40:4-8
Functionalized 2-alkyl derivatives of inosinic acid have been synthesized to serve as reversible as well as irreversible inhibitors of the human type II enzyme inosine monophosphate dehydrogenase. These compounds were designed to react with Cys-331 o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1142fc797851bb6553231b017bc89806
https://doi.org/10.1021/jm960732v
https://doi.org/10.1021/jm960732v
Autor:
Josef Fried, Han-Zhong Zhang
Publikováno v:
Synthetic Communications. 26:351-355
A short and practical synthesis of 2-vinylinosine from readily available materials is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52458421bf9fc66b9d7b9cdebc38346f
https://doi.org/10.1080/00397919608003623
https://doi.org/10.1080/00397919608003623
Synthesis of a thromboxane A2 receptor antagonist possessing the dioxabicycloheptane nucleus of TXA2
Publikováno v:
The Journal of Organic Chemistry. 58:5724-5731
The synthesis of the TXA 2 /PGH 2 receptor antagonist 6 ([7,7-difluoro-3-[(N-heptanoylglycyl)aminomethyl-2,6-dioxabicyclo[3.1.1]hept-4-yl]-5-heptenoic acid )from the known chiral intermediate (-)-8 is described. The critical reaction is the inversion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccb6650b56eb6ff6958a3769e7cf5d47
https://doi.org/10.1021/jo00073a035
https://doi.org/10.1021/jo00073a035
Publikováno v:
The Journal of Organic Chemistry. 58:1882-1886
The high enantio- and regiospecificity reported from this laboratory for the hydrolysis of the diacetate (±)-2 with pig liver esterase to yield enantiomericly pure monoacetate (+)-3a has been investigated further to define some of the structural fea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df36f3b1a321cc544aa9dbca609ba809
https://doi.org/10.1021/jo00059a046
https://doi.org/10.1021/jo00059a046
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f96cbd738c119d285e1a7f1198ec73d0
https://doi.org/10.1002/chin.199308292
https://doi.org/10.1002/chin.199308292
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::046ef29f882379e4e96c99db54fa4be1
https://doi.org/10.1002/chin.199331069
https://doi.org/10.1002/chin.199331069
Publikováno v:
ChemInform. 25
The synthesis of the TXA 2 /PGH 2 receptor antagonist 6 ([7,7-difluoro-3-[(N-heptanoylglycyl)aminomethyl-2,6-dioxabicyclo[3.1.1]hept-4-yl]-5-heptenoic acid )from the known chiral intermediate (-)-8 is described. The critical reaction is the inversion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::971f104600c141420f92de603ba89789
https://doi.org/10.1002/chin.199406257
https://doi.org/10.1002/chin.199406257
Autor:
Josef Fried, Han-Zhong Zhang
Publikováno v:
ChemInform. 27
A short and practical synthesis of 2-vinylinosine from readily available materials is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fb0eb89c0556b03854849fdf82827db
https://doi.org/10.1002/chin.199624235
https://doi.org/10.1002/chin.199624235
Autor:
Elwood Titus, Josef Fried
Publikováno v:
The Journal of biological chemistry. 168(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f30bc6eee001226a3a4e056c8b8d25f
https://pubmed.ncbi.nlm.nih.gov/20291099
https://pubmed.ncbi.nlm.nih.gov/20291099
Autor:
Josef Fried
Publikováno v:
Steroids. 57:384-391
The author's recollections of the events leading to the first synthesis of the 9α-fluorosteroids at Squibb, the further development of this discovery and its influence on the steroid industry are presented.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ad788c004c450fee88392f821bb1ba
https://doi.org/10.1016/0039-128x(92)90082-k
https://doi.org/10.1016/0039-128x(92)90082-k