The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance

Autor: Jérémie Gautheron, Mihael Vucur, Anne T. Schneider, Ilenia Severi, Christoph Roderburg, Sanchari Roy, Matthias Bartneck, Peter Schrammen, Mauricio Berriel Diaz, Josef Ehling, Felix Gremse, Felix Heymann, Christiane Koppe, Twan Lammers, Fabian Kiessling, Niels Van Best, Oliver Pabst, Gilles Courtois, Andreas Linkermann, Stefan Krautwald, Ulf P. Neumann, Frank Tacke, Christian Trautwein, Douglas R. Green, Thomas Longerich, Norbert Frey, Mark Luedde, Matthias Bluher, Stephan Herzig, Mathias Heikenwalder, Tom Luedde

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)

The kinase RIPK3 initiates necroptosis, which has been reported to promote inflammation in various pathological conditions. Here, the authors show that genetic ablation of Ripk3results in adipocyte apoptosis and white adipose tissue inflammation in o

Externí odkaz: https://doaj.org/article/5ab7094df7b24c7e834e933314f7ba85

Incidental Finding Prevalences in 3-Tesla Brain and Spine MRI of Military Pilot Applicants

Autor: Frank Weber, Frank M. Jakobs, Sven-Erik Sönksen, Heinz Knopf, Hans-Jrgen Noblé, Sven Kühn, Jörg Frischmuth, Josef Ehling

Publikováno v: Aerospace Medicine and Human Performance. 92:146-152

INTRODUCTION: Incidental findings in brain and spine MRI are common. In aerospace medicine, pilot selection may be affected by improved sensitivity of modern MRI devices. We investigated the occurrence of medically unfit rates caused by incidental fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aceb6c8eaeb3ec18c6ddaab8a12dca46
https://doi.org/10.3357/amhp.5749.2021

Elastin imaging enables noninvasive staging and treatment monitoring of kidney fibrosis

Autor: Jürgen Floege, Christoph Daniel, Maike Baues, Fabian Kiessling, Julio Saez-Rodriguez, Rafael Kramann, René M. Botnar, Kerstin Amann, Qinxue Sun, David C. Onthank, Peter Boor, Barbara M. Klinkhammer, Natascha Drude, Sonja Djudjaj, Twan Lammers, Ralf Weiskirchen, Hyojin Kim, Josef Ehling

Publikováno v: Science Translational Medicine, 11(486):eaat4865. American Association for the Advancement of Science
Sun, Q, Baues, M, Klinkhammer, B M, Ehling, J, Djudjaj, S, Drude, N I, Daniel, C, Amann, K, Kramann, R, Kim, H, Saez-Rodriguez, J, Weiskirchen, R, Onthank, D C, Botnar, R M, Kiessling, F, Floege, J, Lammers, T & Boor, P 2019, ' Elastin imaging enables noninvasive staging and treatment monitoring of kidney fibrosis ', Science Translational Medicine, vol. 11, no. 486, eaat4865 . https://doi.org/10.1126/scitranslmed.aat4865
Science Translational Medicine
Sci Transl Med

Fibrosis is the common endpoint and currently the best predictor of progression of chronic kidney diseases (CKD). Despite several drawbacks, biopsies remain the only available means to specifically assess the extent of renal fibrosis. Here we show th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df26b70859fcda38ef76b593b5e355ce
https://doi.org/10.1126/scitranslmed.aat4865

Imalytics Preclinical: Interactive Analysis of Biomedical Volume Data

Autor: Felix Gremse, Fabian Kiessling, Twan Lammers, Jan Robert Menzel, Marius Stärk, Josef Ehling

Publikováno v: Theranostics
Theranostics 6(3), 328-341 (2016). doi:10.7150/thno.13624
Theranostics, 6(3), 328-341. Ivyspring International Publisher

A software tool is presented for interactive segmentation of volumetric medical data sets. To allow interactive processing of large data sets, segmentation operations, and rendering are GPU-accelerated. Special adjustments are provided to overcome GP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b284c3df9ed21aa1f27482a0fbdefa41
http://europepmc.org/articles/PMC4737721

Role of Platelet-Derived Growth Factor-CC in Capillary Rarefaction in Renal Fibrosis

Autor: Claudia R.C. van Roeyen, Josef Ehling, Janka Bábíčková, Petra A. I. Hautvast, Floor M.E.G. Steegh, Frank Eitner, Taizo Nakagawa, Peter Boor, Sonja Djudjaj, Ina V. Martin, Ulf Eriksson, Felix Gremse, Carine J. Peutz-Kootstra, Jürgen Floege, Tammo Ostendorf, Eva Bücher, Twan Lammers

Publikováno v: American Journal of Pathology, 185(8), 2132-2142. Elsevier Science
American journal of pathology, 185(8), 2132-2142. Elsevier

We have identified platelet-derived growth factor (PDGF)-CC as a potent profibrotic mediator in kidney fibrosis and pro-angiogenic mediator in glomeruli. Because renal fibrosis is associated with progressive capillary rarefaction, we asked whether PD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9783fbd01fab525f70ddea5b6c8e0d6
https://doi.org/10.1016/j.ajpath.2015.04.022