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Agonists binding nicotinic receptors elicit specific channel-opening patterns at αγ and αδ sites

Autor: Dmitrij Ljaschenko, Manfred Heckmann, Patrick Stock, Josef Dudel

Publikováno v: The Journal of Physiology. 592:2501-2517

Key points High-resolution patch clamp currents evoked by epibatidine (Ebd), carbamylcholine (CCh) and acetylcholine (ACh) were compared. Ebd binds with 75-fold higher affinity at αγ than at αδ sites, whereas CCh and ACh prefer αδ sites of nico

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2480983b3641bf7c00b0d98d4bfbbe8a
https://doi.org/10.1113/jphysiol.2013.267781

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Depolarization amplitude and Ca2+-inflow control the time course of quantal releases at murine motor nerve terminals

Autor: Josef Dudel

Publikováno v: European Journal of Neuroscience. 30:1219-1226

In order to test whether the time courses of quantal releases after a depolarization pulse are affected by the depolarization amplitude, time courses were measured for small depolarization pulses that elicited close to threshold releases and for larg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b3739f212ad142a7162678d528e7f96
https://doi.org/10.1111/j.1460-9568.2009.06915.x

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The time course of transmitter release in mouse motor nerve terminals is differentially affected by activation of muscarinic M1 or M2 receptors

Autor: Josef Dudel

Publikováno v: European Journal of Neuroscience. 26:2160-2168

At endplates of mouse diaphragms the effects of activation of presynaptic muscarinic M1 and M2 autoreceptors on the time courses of monoquantal releases have been investigated at 20 degrees C. Quantal excitatory postsynaptic currents (qEPSCs) were el

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d962b1ad881bf115f1914113eddb46c
https://doi.org/10.1111/j.1460-9568.2007.05770.x

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Short openings in high resolution single channel recordings of mouse nicotinic receptors

Autor: Sabine Heckmann, Manfred Heckmann, Stefan Hallermann, Josef Dudel

Publikováno v: The Journal of Physiology. 563:645-662

The temporal fine structure of single channel currents was studied to obtain information on how agonists open nicotinic acetylcholine receptor channels. Currents were recorded from mouse myoballs with quartz pipettes in the on-cell mode of the patch-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f14559a70e4b29ed7241f3775d2f0f54
https://doi.org/10.1113/jphysiol.2004.080606

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A receptor for presynaptic glutamatergic autoinhibition is a glutamate transporter

Autor: Josef Dudel, Marion Schramm

Publikováno v: European Journal of Neuroscience. 18:902-910

Monoquantal excitatory postsynaptic currents were recorded by means of a perfused macropatch electrode from 9 to 15 micro m stretches of crayfish neuromuscular junctions. The excitatory transmitter l-glutamate superfused to a terminal inhibits quanta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c185bf81c303bae3010b019b68b93f66
https://doi.org/10.1046/j.1460-9568.2003.02799.x

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Use of Knockout Mice Reveals Involvement of M2-Muscarinic Receptors in Control of the Kinetics of Acetylcholine Release

Autor: Hanna Parnas, Jürgen Wess, Itzchak Parnas, J. Gomeza, Josef Dudel, Inna Slutsky

Publikováno v: Journal of Neurophysiology. 89:1954-1967

We have previously suggested that presynaptic M2-muscarinic receptors (M2R) are involved in the control of the time course of evoked acetylcholine release in the frog neuromuscular junction. The availability of knockout mice lacking functional M2R (M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545ec12bd31e5dd643eca2f0237babd6
https://doi.org/10.1152/jn.00668.2002

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Quantal endplate currents from newborn to adult mice and the switch from embryonic to adult channel type

Autor: Josef Dudel, Manfred Heckmann

Publikováno v: Neuroscience Letters. 326:13-16

Quantal endplate currents (qEPCs) were recorded extracellularly by a macropatch electrode from excised diaphragms of mice. During the first 3 days after birth, the mean rise time t(r) was 0.5 ms (0.1-0.9 peak, 20 degrees C). Double-exponential, ampli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c42676ffa5024d93246010dea83ff8ae
https://doi.org/10.1016/s0304-3940(02)00280-x

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α‐Conotoxin M1 (CTx) blocks αδ binding sites of adult nicotinic receptors while ACh binding at αε sites elicits only small and short quantal synaptic currents

Autor: Josef Dudel

Publikováno v: Physiological Reports

In ‘embryonic’ nicotinic receptors, low CTx concentrations are known to block only the αδ binding site, whereas binding of ACh at the αγ‐site elicits short single channel openings and short bursts. In adult muscles the αγ‐ is replaced b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662179b17bac79e5b1b4f76f55b27715
http://europepmc.org/articles/PMC4332195

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Activation of rat recombinant α1β2γ2S GABAA receptor by the insecticide ivermectin

Autor: Josef Dudel, Alexandra Lepier, Helmuth Adelsberger

Publikováno v: European Journal of Pharmacology. 394:163-170

In the present study, the activation of rat recombinant α1β2γ2S γ-aminobutyric acid (GABA)-ergic Cl− channel expressed in human embryonic kidney (HEK) 293 cells by ivermectin was investigated. Maximal activation of the channel occurred with GAB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09e1b7e8245f0314028bd7032594bcd1
https://doi.org/10.1016/s0014-2999(00)00164-3

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