Zobrazeno 1 - 10
of 275
pro vyhledávání: '"Josef Bischofberger"'
Autor:
Stefan Vestring, Alexandra Dorner, Jonas Scholliers, Konstantin Ehrenberger, Andrea Kiss, Luis Arenz, Alice Theiss, Paul Rossner, Sibylle Frase, Catherine Du Vinage, Elisabeth Wendler, Tsvetan Serchov, Katharina Domschke, Josef Bischofberger, Claus Normann
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The partial N-methyl-D-aspartate receptor (NMDAR) agonist d-Cycloserine (DCS) has been evaluated for the treatment of a wide variety of psychiatric disorders, including dementia, schizophrenia, depression and for the augmentation of exposure
Externí odkaz:
https://doaj.org/article/3057b93ab34842c993ae0819b3eda426
Autor:
Lisa Traunmüller, Jan Schulz, Raul Ortiz, Huijuan Feng, Elisabetta Furlanis, Andrea M. Gomez, Dietmar Schreiner, Josef Bischofberger, Chaolin Zhang, Peter Scheiffele
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112173- (2023)
Summary: The specification of synaptic properties is fundamental for the function of neuronal circuits. “Terminal selector” transcription factors coordinate terminal gene batteries that specify cell-type-specific properties. Moreover, pan-neurona
Externí odkaz:
https://doaj.org/article/b4ad219ae10d47dea5202e264994b7ad
Publikováno v:
Cell Reports, Vol 37, Iss 1, Pp 109768- (2021)
Summary: GABA can depolarize immature neurons close to the action potential (AP) threshold in development and adult neurogenesis. Nevertheless, GABAergic synapses effectively inhibit AP firing in newborn granule cells of the adult hippocampus as earl
Externí odkaz:
https://doaj.org/article/6592b37040634c9286d043a21808d9c6
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Synergistic interactions between independent synaptic input streams may fundamentally change the action potential (AP) output. Using partial information decomposition, we demonstrate here a substantial contribution of synergy between somatic and apic
Externí odkaz:
https://doaj.org/article/7bd263548f824333bcdaea9ae853619b
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Somatostatin+ (SOM+ ) GABAergic interneurons are known to fine-tune synaptic plasticity as they inhibit dendritic spikes and burst firing. Here, the authors show that both SOM+ and NOS+ interneurons preferentially recruit nonlinear outward-rectifying
Externí odkaz:
https://doaj.org/article/2b44f2781de8400fa51141e60c25aa5b
Autor:
Stefania Fedele, Ginetta Collo, Katharina Behr, Josef Bischofberger, Stephan Müller, Tilo Kunath, Klaus Christensen, Anna Lisa Gündner, Martin Graf, Ravi Jagasia, Verdon Taylor
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Human induced pluripotent stem cells (hiPSCs) are invaluable to study developmental processes and disease mechanisms particularly in the brain. hiPSCs can be differentiated into mature and functional dopaminergic (DA) neurons. Having robust
Externí odkaz:
https://doaj.org/article/5ed1c6e948cd4fae965b4783e0f2222b
Autor:
Veronica Costa, Stefan Aigner, Mirko Vukcevic, Evelyn Sauter, Katharina Behr, Martin Ebeling, Tom Dunkley, Arno Friedlein, Sannah Zoffmann, Claas A. Meyer, Frédéric Knoflach, Sebastian Lugert, Christoph Patsch, Fatiha Fjeldskaar, Laurie Chicha-Gaudimier, Anna Kiialainen, Paolo Piraino, Marc Bedoucha, Martin Graf, Sebastian Jessberger, Anirvan Ghosh, Josef Bischofberger, Ravi Jagasia
Publikováno v:
Cell Reports, Vol 15, Iss 1, Pp 86-95 (2016)
Hyperfunction of the mTORC1 pathway has been associated with idiopathic and syndromic forms of autism spectrum disorder (ASD), including tuberous sclerosis, caused by loss of either TSC1 or TSC2. It remains largely unknown how developmental processes
Externí odkaz:
https://doaj.org/article/c453283d07954edc80795548e6cfa550
Autor:
Liyi Li, Sébastien Sultan, Stefanie Heigele, Charlotte Schmidt-Salzmann, Nicolas Toni, Josef Bischofberger
Publikováno v:
eLife, Vol 6 (2017)
In adult neurogenesis young neurons connect to the existing network via formation of thousands of new synapses. At early developmental stages, glutamatergic synapses are sparse, immature and functionally 'silent', expressing mainly NMDA receptors. He
Externí odkaz:
https://doaj.org/article/5fcf88ac6887457d8b4d4e7c5e2cb3f9
Autor:
Inga Herpfer, Henning Hezel, Wilfried Reichardt, Kristin Clark, Julia Geiger, Claus M Gross, Andrea Heyer, Valentin Neagu, Harsharan Bhatia, Hasan C Atas, Bernd L Fiebich, Josef Bischofberger, Carola A Haas, Klaus Lieb, Claus Normann
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46004 (2012)
BackgroundEarly life trauma is an important risk factor for many psychiatric and somatic disorders in adulthood. As a growing body of evidence suggests that brain plasticity is disturbed in affective disorders, we examined the short-term and remote e
Externí odkaz:
https://doaj.org/article/8a420d7094354076b73ad24aaca02f90
Publikováno v:
Frontiers in Neuroscience, Vol 3 (2009)
Adult hippocampal neurogenesis is regulated by activity. But how do neural precursor cells in the hippocampus respond to surrounding network activity and translate increased neural activity into a developmental program? Here we show that long-term po
Externí odkaz:
https://doaj.org/article/2eee6f9088034dd19c19af9382d59f2e