Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Josef A. Gramespacher"'
Autor:
Shion A. Lim, Josef A. Gramespacher, Katarina Pance, Nicholas J. Rettko, Paige Solomon, Jing Jin, Irene Lui, Susanna K. Elledge, Jia Liu, Colton J. Bracken, Graham Simmons, Xin X. Zhou, Kevin K. Leung, James A. Wells
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Numerous neutralizing antibodies that target SARS-CoV-2 have been reported, and most directly block binding of the viral Spike receptor-binding domain (RBD) to angiotensin-converting enzyme II (ACE2). Here, we deliberately exploit non-neutralizing RB
Externí odkaz:
https://doaj.org/article/58387a18a15c49f9b2ec691ffba6d02b
Autor:
Katarina Pance, Josef A. Gramespacher, James R. Byrnes, Fernando Salangsang, Juan-Antonio C. Serrano, Adam D. Cotton, Veronica Steri, James A. Wells
Publikováno v:
Nature biotechnology, vol 41, iss 2
Targeted degradation of cell surface and extracellular proteins via lysosomal delivery is an important means to modulate extracellular biology. However, these approaches have limitations due to lack of modularity, ease of development, restricted tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ad926195dc4d40864e8bef242196e01
https://escholarship.org/uc/item/1bd0b1dm
https://escholarship.org/uc/item/1bd0b1dm
Publikováno v:
ACS Chemical Biology. 17:1259-1268
Targeted protein degradation is a promising therapeutic strategy capable of overcoming the limitations of traditional occupancy-based inhibitors. By ablating all of the associated functions of a protein at once, the event-driven pharmacology of degra
Autor:
Katarina, Pance, Josef A, Gramespacher, James R, Byrnes, Fernando, Salangsang, Juan-Antonio C, Serrano, Adam D, Cotton, Veronica, Steri, James A, Wells
Publikováno v:
Nature biotechnology.
Targeted degradation of cell surface and extracellular proteins via lysosomal delivery is an important means to modulate extracellular biology. However, these approaches have limitations due to lack of modularity, ease of development, restricted tiss
Publikováno v:
Journal of the American Chemical Society
Journal of the American Chemical Society, vol 143, iss 2
Journal of the American Chemical Society, vol 143, iss 2
Targeted protein degradation has emerged as a new paradigm to manipulate cellular proteostasis. Proteolysis-targeting chimeras (PROTACs) are bifunctional small molecules that recruit an E3 ligase to a target protein of interest, promoting its ubiquit
Publikováno v:
J Am Chem Soc
Naturally split inteins drive the ligation of separately expressed polypeptides through a process called protein trans splicing (PTS). The ability to control PTS – so-called conditional protein splicing (CPS) - has led to the development of powerfu
Autor:
Graham Simmons, Josef A. Gramespacher, Irene Lui, Shion A. Lim, Colton J Bracken, Jing Jin, Kevin Leung, Xin X. Zhou, Jia Liu, Paige Solomon, James A. Wells, Susanna K. Elledge, Nicholas J. Rettko, Katarina Pance
Publikováno v:
mAbs
article-version (VoR) Version of Record
mAbs, vol 13, iss 1
article-version (VoR) Version of Record
mAbs, vol 13, iss 1
Numerous neutralizing antibodies that target SARS-CoV-2 have been reported, and most directly block binding of the viral Spike receptor-binding domain (RBD) to angiotensin-converting enzyme II (ACE2). Here, we deliberately exploit non-neutralizing RB
Autor:
Frauke Muecksch, Nicholas J. Rettko, Fabian Schmidt, Paige Solomon, Shion A. Lim, Oren S. Rosenberg, Paul D. Bieniasz, Davide F. Robbiani, Beth S. Zha, Kevin Leung, James A. Wells, Jia Liu, Julio C. C. Lorenzi, Lisa L. Kirkemo, Josef A. Gramespacher, Theodora Hatziioannou, Susanna K. Elledge, Michel C. Nussenzweig, Yiska Weisblum, Xin X. Zhou, Irene Lui
A serious public health crisis is currently unfolding due to the SARS-CoV-2 pandemic. SARS-CoV-2 viral entry depends on an interaction between the receptor binding domain of the trimeric viral Spike protein (Spike-RBD) and the dimeric human angiotens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0319142d11e9f08bb568cff79c3337d6
https://doi.org/10.1101/2020.05.21.109157
https://doi.org/10.1101/2020.05.21.109157
Publikováno v:
J Am Chem Soc
Split inteins associate to trigger protein splicing in trans, a post-translational modification in which protein sequences fused to the intein pair are ligated together in a traceless manner. Recently, a family of naturally split inteins has been ide
Publikováno v:
Protein Science. 27:614-619
Naturally split inteins mediate a traceless protein ligation process known as protein trans-splicing (PTS). Although frequently used in protein engineering applications, the efficiency of PTS can be reduced by the tendency of some split intein fusion