Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Josef, Skoda"'
Autor:
Ivana Mejdrová, Jan Dušek, Kryštof Škach, Alžbeta Stefela, Josef Skoda, Karel Chalupský, Klára Dohnalová, Ivona Pavkova, Thales Kronenberger, Azam Rashidian, Lucie Smutná, Vojtěch Duchoslav, Tomas Smutny, Petr Pávek, Radim Nencka
Publikováno v:
Journal of Medicinal Chemistry. 66:2422-2456
Autor:
Barbora Boltnarova, Jana Kubackova, Josef Skoda, Alzbeta Stefela, Monika Smekalova, Petra Svacinova, Ivona Pavkova, Milan Dittrich, Daniel Scherman, Jarmila Zbytovska, Petr Pavek, Ondrej Holas
Publikováno v:
Nanomaterials, Vol 11, Iss 3, p 749 (2021)
Macrophages possess an innate ability to scavenge heterogenous objects from the systemic circulation and to regulate inflammatory diseases in various organs via cytokine production. That makes them attractive targets for nanomedicine-based therapeuti
Externí odkaz:
https://doaj.org/article/035f8cab806046ac9246a965110ad88a
Autor:
Josef Skoda, Jan Dusek, Martin Drastik, Alzbeta Stefela, Klara Dohnalova, Karel Chalupsky, Tomas Smutny, Stanislav Micuda, Sabine Gerbal-Chaloin, Petr Pavek
Publikováno v:
Cells, Vol 9, Iss 12, p 2532 (2020)
The constitutive androstane receptor (CAR) is the essential regulator of genes involved both in xenobiotic and endobiotic metabolism. Diazepam has been shown as a potent stimulator of CAR nuclear translocation and is assumed as an indirect CAR activa
Externí odkaz:
https://doaj.org/article/7c2b6c2d073147058fe91e7104860ab2
Autor:
Alejandro Carazo, Jan Dusek, Ondrej Holas, Josef Skoda, Lucie Hyrsova, Tomas Smutny, Tomas Soukup, Martin Dosedel, Petr Pávek
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
The constitutive androstane receptor (CAR) is a nuclear receptor involved mainly in xenobiotic and endobiotic metabolism regulation. CAR is activated directly by its ligands via the ligand binding domain (LBD) or indirectly by inhibition of the epide
Externí odkaz:
https://doaj.org/article/36d68d817c70409fb41388f0ef051e2e
Autor:
Eduard Jirkovský, Jan Korábečný, Tomáš Šimůnek, Anna Jirkovská, Veronika Skalická, Hana Bavlovič Piskáčková, Martin Štěrba, Jan Kubes, Iuliia Melnikova, Jaroslav Roh, Tomas Kucera, Caroline A. Austin, Josef Skoda, Lucie Nováková, Galina Karabanovich
Publikováno v:
Journal of Medicinal Chemistry. 64:3997-4019
Cardioprotective activity of dexrazoxane (ICRF-187), the only clinically approved drug against anthracycline-induced cardiotoxicity, has traditionally been attributed to its iron-chelating metabolite. However, recent experimental evidence suggested t
Autor:
Josef Skoda, Klara Dohnalova, Karel Chalupsky, Aaron Stahl, Markus Templin, Jana Maixnerova, Stanislav Micuda, Lars Grøntved, Albert Braeuning, Petr Pavek
Publikováno v:
Skoda, J, Dohnalova, K, Chalupsky, K, Stahl, A, Templin, M, Maixnerova, J, Micuda, S, Grøntved, L, Braeuning, A & Pavek, P 2022, ' Off-target lipid metabolism disruption by the mouse constitutive androstane receptor ligand TCPOBOP in humanized mice ', Biochemical Pharmacology, vol. 197, 114905 . https://doi.org/10.1016/j.bcp.2021.114905
Biochemical pharmacology
Biochemical pharmacology
The constitutive androstane receptor (CAR) controls xenobiotic clearance, regulates liver glucose, lipid metabolism, and energy homeostasis. These functions have been mainly discovered using the prototypical mouse-specific CAR ligand TCPOBOP in wild-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ea4d97bdea4366ddc6d0d793fba9ec
https://portal.findresearcher.sdu.dk/da/publications/063b1649-44df-41de-b110-b8485051d696
https://portal.findresearcher.sdu.dk/da/publications/063b1649-44df-41de-b110-b8485051d696
Autor:
Petr, Pavek, Jan, Dusek, Tomas, Smutny, Lukas, Lochman, Radim, Kucera, Josef, Skoda, Lucie, Smutna, Rajamanikkam, Kamaraj, Pavel, Soucek, Radim, Vrzal, Zdenek, Dvorak
Publikováno v:
Molecular nutritionfood research. 66(9)
CYP3A4 is the most important drug-metabolizing enzyme regulated via the vitamin D receptor (VDR) in the intestine. However, less is known about VDR in the regulation of CYP3A4 and other drug-metabolizing enzymes in the liver.This study investigates w
Autor:
Eva Kudova, Miriama Hutníková, Josef Skoda, Amit V. Pandey, Petr Pavek, Alzbeta Stefela, Miroslav Kaspar, Milos Hroch, Martin Drastik, Ondrej Holas, Tomas Smutny, Stanislav Micuda
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 202:105702
Bile acids (BAs) are important signaling molecules acting via the farnesoid X nuclear receptor (FXR) and the membrane G protein-coupled bile acid receptor 1 (GPBAR1). Besides deconjugation of BAs, the oxidoreductive enzymes of colonic bacteria and he
Autor:
Josef, Skoda
Publikováno v:
Vnitrni lekarstvi. 51(12)
Autor:
Josef, Skoda
Publikováno v:
Casopis lekaru ceskych. 144(11)
The article deals with the life and work of the eminent professor of internal medicine Josef Skoda, a native of Plzen, who especially deserved of the introduction of examination by percussion and auscultation. He supported materially his nephew Emil