Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Josef, Messinger"'
Autor:
Jean Quancard, Anna Vulpetti, Anders Bach, Brian Cox, Stéphanie M. Guéret, Ingo V. Hartung, Hannes F. Koolman, Stefan Laufer, Josef Messinger, Gianluca Sbardella, Russell Craft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514e82a2fe9693d245f09a5e32cb9327
https://hdl.handle.net/11386/4818531
https://hdl.handle.net/11386/4818531
Autor:
Mareike, Czuppa, Ashutosh, Dhingra, Qihui, Zhou, Carina, Schludi, Laura, König, Elisabeth, Scharf, Daniel, Farny, Anupriya, Dalmia, Joachim, Täger, Melissa, Castillo-Lizardo, Eszter, Katona, Kohji, Mori, Tina, Aumer, Florian, Schelter, Markus, Müller, Thomas, Carell, Tuomo, Kalliokoski, Josef, Messinger, Patrizia, Rizzu, Peter, Heutink, Dieter, Edbauer
Publikováno v:
Cell reports. 39(10)
An intronic (G
Autor:
Mareike Czuppa, Ashutosh Dhingra, Qihui Zhou, Carina Schludi, Laura König, Elisabeth Scharf, Daniel Farny, Anupriya Dalmia, Joachim Täger, Melissa Castillo-Lizardo, Eszter Katona, Kohji Mori, Tina Aumer, Florian Schelter, Markus Müller, Thomas Carell, Tuomo Kalliokoski, Josef Messinger, Patrizia Rizzu, Peter Heutink, Dieter Edbauer
Publikováno v:
Cell reports 39(10), 110913 (2022). doi:10.1016/j.celrep.2022.110913
An intronic (G4C2)n expansion in C9orf72 causes amyotrophic lateral sclerosis and frontotemporal dementia primarily through gain-of-function mechanisms: the accumulation of sense and antisense repeat RNA foci and dipeptide repeat (DPR) proteins (poly
Autor:
Jean Quancard, Gianluca Sbardella, Brian Cox, Stéphanie M. Guéret, Stefan Laufer, Hannes Fiepko Koolman, Dirk Finsinger, Russell Craft, Josef Messinger, Anders Bach, Ingo Hartung
Publikováno v:
ChemMedChem. 16(11)
Phenotypic drug discovery has a long track record of delivering innovative drugs and has received renewed attention in the last few years. The promise of this approach, however, comes with several challenges that should be addressed to avoid wasting
Autor:
Parvin Ahooghalandari, Nina Hanke, Michael Thorpe, Andreas Witte, Josef Messinger, Lars Hellman
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65988 (2013)
Chymotrypsin-like serine proteases are found in high abundance in mast cell granules. By site-directed mutatgenesis, we have previously shown that basic amino acids in positions 143 and 192 (Arg and Lys respectively) of the human mast cell chymase ar
Externí odkaz:
https://doaj.org/article/4bb364303f8e429e9d7f977fd172f5ba
Autor:
Brian Cox, Stéphanie M. Guéret, Jean Quancard, Stefan Laufer, Hannes Fiepko Koolman, Dirk Finsinger, Josef Messinger, Gianluca Sbardella, Ingo Hartung
As part of an initiative aimed to share best practices in Medicinal Chemistry, the European Federation for Medicinal Chemistry (EFMC) is preparing a series of webinars and slide sets focused on the early phase of drug discovery. This educational mate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f445aaea9200b8e1f2c7e71039e0cc
http://hdl.handle.net/11386/4750304
http://hdl.handle.net/11386/4750304
Autor:
Gabriele Möller, Bettina Husen, Dorota Kowalik, Leena Hirvelä, Dariusz Plewczynski, Leszek Rychlewski, Josef Messinger, Hubert Thole, Jerzy Adamski
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e10969 (2010)
Steroid-related cancers can be treated by inhibitors of steroid metabolism. In searching for new inhibitors of human 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD 1) for the treatment of breast cancer or endometriosis, novel substances based
Externí odkaz:
https://doaj.org/article/06b4b6d915cf4e4aa8a692666c9b6054
Autor:
Marta Olszak-Płachta, Mateusz Nowak, Hugh Chapman, Magdalena Sieprawska-Lupa, Raymond Horvath, Klaudia Stefańska, Maciej Mikulski, Marcin Król, Katja Kuokkanen, Michal Galezowski, Mariusz Galek, Niina Jalava, Justyna Adamczyk, Joanna Szeremeta-Spisak, Ullamari Pesonen, Josef Messinger, Harri Salo, Radosław Obuchowicz, Charles-Henry Fabritius, Anna Buda, Peteris Prusis, Timo Korjamo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2610-2615
A series of 1-Sulfonyl-6-Piperazinyl-7-Azaindoles, showing strong antagonistic activity to 5-HT6 receptor (5-HT6R) was synthesized and characterized. The series was optimized to reduce activity on D2 receptor. Based on the selectivity against this of
Medicinal chemistry departments in pharmaceutical companies or research institutes are considered to be providers of new chemical entities for testing in biological systems on mg and g scales. Time, yields and flexibility of a reaction play a major r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::223ec1553717fe142ce01dbaddd95cca
https://doi.org/10.1039/9781782625940-00101
https://doi.org/10.1039/9781782625940-00101
Publikováno v:
Journal of Biotechnology. 150:161-170
While phase I and phase II drug metabolites are important for drug development and toxicity studies, e.g. in the context of metabolites in safety testing (MIST), they are often not commercially available and their classical chemical synthesis can be