Zobrazeno 1 - 10
of 622
pro vyhledávání: '"Josef, Köhrle"'
Autor:
Franziska Lademann, Eddy Rijntjes, Josef Köhrle, Elena Tsourdi, Lorenz C. Hofbauer, Martina Rauner
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Hyperthyroidism is a well-known trigger of high bone turnover that can lead to the development of secondary osteoporosis. Previously, we have shown that blocking bone morphogenetic protein (BMP) signaling systemically with BMPR1A-Fc can prev
Externí odkaz:
https://doaj.org/article/8b89a9a3c6184875be917878699170d0
Autor:
Rodrigo Moreno-Reyes, Ulla Feldt-Rasmussen, Agnieszka Piekiełko-Witkowska, Adriana Gaspar da Rocha, Corin Badiu, Josef Köhrle, Leonidas Duntas
Publikováno v:
European Thyroid Journal, Vol 13, Iss 1, Pp 1-6 (2024)
In 2022, the European Chemicals Agency (ECHA) made a statement concluding that iodine is an endocrine disruptor (ED). We stress the fact that the ECHA opinion ECHA/BPC/357/2022 is based on their misguidedly zooming in on exclusively the biocidal prod
Externí odkaz:
https://doaj.org/article/f43f9cf473704c629d22af9f293b301c
Autor:
Holly Towell, Doreen Braun, Alexander Brol, Andrea di Fonzo, Eddy Rijntjes, Josef Köhrle, Ulrich Schweizer, Clemens Steegborn
Publikováno v:
Biomolecules, Vol 14, Iss 11, p 1373 (2024)
Iodothyronine deiodinases (Dio) are selenocysteine-containing membrane enzymes that activate and inactivate the thyroid hormones (TH) through reductive iodide eliminations. The three deiodinase isoforms are homodimers sharing highly conserved amino a
Externí odkaz:
https://doaj.org/article/907f963ea57340ad810a8e44403b42ad
Autor:
Patricia Gerhardt, Sabine Begall, Caroline Frädrich, Kostja Renko, Alexandra Heinrich, Josef Köhrle, Yoshiyuki Henning
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionAbout 10% of all rodent species have evolved a subterranean way of life, although life in subterranean burrows is associated with harsh environmental conditions that would be lethal to most animals living above ground. Two key adaptations
Externí odkaz:
https://doaj.org/article/5286e23d0814451d927921f629cb686c
Autor:
Patricia Gerhardt, Sabine Begall, Caroline Frädrich, Kostja Renko, Thomas B. Hildebrandt, Susanne Holtze, Alexandra Heinrich, Arne Sahm, Xheni Meci, Josef Köhrle, Eddy Rijntjes, Yoshiyuki Henning
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract African mole-rats are subterranean rodents inhabiting underground burrows. This habitat entails risks of overheating, hypoxia, and scarce food availability. Consequently, many subterranean species have evolved low basal metabolism and low bo
Externí odkaz:
https://doaj.org/article/a34ab3b7d48041248e07b0f0681a47e6
Autor:
Ulrich Schweizer, Eva K. Wirth, Thomas Klopstock, Sabine M. Hölter, Lore Becker, Jackob Moskovitz, Tilman Grune, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Josef Köhrle, Lutz Schomburg
Publikováno v:
Redox Biology, Vol 57, Iss , Pp 102490- (2022)
Mice with constitutive disruption of the Selenop gene have been key to delineate the importance of selenoproteins in neurobiology. However, the phenotype of this mouse model is exquisitely dependent on selenium supply and timing of selenium supplemen
Externí odkaz:
https://doaj.org/article/339455800f054b43a1117382fc1a7aa8
Publikováno v:
Endocrine Connections, Vol 11, Iss 1, Pp 1-3 (2022)
Contemporary medicine focuses its therapeutic approaches on the personalized targeting of key molecular elements with respect to mechanism-based pathways, or molecules involved in pathophysiologically relevant processes that are causally related (or
Externí odkaz:
https://doaj.org/article/1f05b50e39f343fdbc0d6dc0a7d5ac0b
Autor:
Kostja Renko, Helena Kerp, Janina Pape, Eddy Rijntjes, Tanja Burgdorf, Dagmar Führer, Josef Köhrle
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
In animal studies, both in basic science and in toxicological assessment of potential endocrine disruptors, the state of the thyroid hormone (TH) axis is often described and defined exclusively by the concentrations of circulating THs and TSH. Althou
Externí odkaz:
https://doaj.org/article/9422fa19804b4489ba7aa34a691753cc
Publikováno v:
Metabolites, Vol 12, Iss 7, p 582 (2022)
Thyroid hormones, their metabolites, and synthetic analogues are potential anti-steatotic drug candidates considering that subclinical and manifest hypothyroidism is associated with hepatic lipid accumulation, non-alcoholic fatty liver disease, and i
Externí odkaz:
https://doaj.org/article/6f0fc2252d4745c8b3d882266a482fba
Publikováno v:
Metabolites, Vol 12, Iss 6, p 476 (2022)
We examined relationships between thyroid hormone (TH) metabolites in humans by measuring 3,5-diiodothyronine (3,5-T2) and 3-iodothyronamine (3-T1AM) levels after liothyronine administration. In secondary analyses, we measured 3,5-T2 and 3-T1AM conce
Externí odkaz:
https://doaj.org/article/97ad9b389c184b57a8bb9b9cbf0d8a3b